Conserved Protein Domain Family
7tmA_LGR6

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cd15362: 7tmA_LGR6 
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs
The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.
Statistics
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PSSM-Id: 320484
View PSSM: cd15362
Aligned: 6 rows
Threshold Bit Score: 390.306
Threshold Setting Gi: 395132309
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##                   
gi 158519993 562 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPvplpPVKFVVGAIAGANTLTGISCGLLASVDAltfgqfseyGARWETGlg 641
gi 395132309 562 WLVRIGMWSISLVSLLGNSLLLLSLFGSSGnl-sPLHFTVACMGASNLLTGVCTCTLALMDAftigqfnhyGARWEGGlg 640
gi 519882077 554 WVVRLGMWLISLVSLMGNSLLILTVFTSPSyl-sPVKFIIGTISGANLLTGLCTGTLALVDArtfgefalhGAQWEMGag 632
gi 483520037 419 WIIRLGVWVIVLVSVLCNGLVILAVFASPSyl-sPVKFVIGSIAGANMLTGIYCSMLALVDAltygqfakfGARWETGtg 497
gi 556976020 548 WVVRLGVWVIVVASVICNALVILTVFASPGyl-sPVKFVIGSIAGANMLTGIDSGVLAFVDAltfgqfakyGAKWETGlg 626
gi 632953361 551 WVIRIGVWAIVLISVVCNGLVITTIFASPTyl-sPVKFVIGLIAAANLLTGLYNGILAIVDAltfaefakhGAKWETGlg 629
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ###### ##  #                                            # #####                 
gi 158519993 642 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRaYGKSPsLGSVRAGVLGCLALAGLAAALPLASVGEYgasPLCLPya 721
gi 395132309 641 CQATGWVWVFASEASVLLLTLAAVQCGVSVTCARfYGKSPsLGSVRTCAVFCLSLSLTLASLPLVGVGDYgssPFCLPsp 720
gi 519882077 633 CRAVGFLSVLASEGSILFLTLAAVQCSVSVSCARaYGKSPsLGSVRAAAVACLALSLAVAALPLIGVGEYgatPLCMPsp 712
gi 483520037 498 CRVTGFLSVFASEAAIFLLTLAAVQCSISVSCVRgYRKAPsLGKVKAAALCCLLLSSVAAVLPLFSIGEYgasPLCLPyp 577
gi 556976020 627 CKAAGFVSVFASEASILFLTLAAVQCSISVSCVRaYGKSPsFSSVKVAALCCVVWSTTAATLPLFSVGEYgttPLCLPsp 706
gi 632953361 630 CRITGFMSVFASEASILFLTLAAVQCSISVSCVRaYGKSPsFSSVKIAAFCCVALSFSAAALPLCSVGEFgtsPLCLPsp 709
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #  ### ### ##                                             #  ## ##  #  
gi 158519993 722 pp---egqpAALGFTVALVMMNSFCFLVVAGAYIKLYCDlprGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASML 798
gi 395132309 721 lpppasrlpSSLGFPLTLIMINTFCLLLVISSYIRLYCEllrGECEGLWDCAMIKHVAWLIFTNSLLYVPVAFLSLCSLL 800
gi 519882077 713 lp---dgepSTLGFMVALIMMNSLCFLVITGTYIKLYWDlmkGDFDSIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLL 789
gi 483520037 578 ip---dgktATLGFTVALVMTNMLCFLTITGTYIRLYCNllkGEFSAVWDCAMVKHVAWLIFTNCLLYCPVAFLTFSSTL 654
gi 556976020 707 lp---dgklSSLGFTVALVMMNTLCFLVITGTYIKLYCDllkGEFDTIWDCAMIKHVAWLIFTNCLLYCPMAFLTFSSLL 783
gi 632953361 710 ip---dgkpSTLGFMVALIMMNTLCFLVITGTYTKLYCDlmkGEFDSIWDCAMIKHVAWLIFTNCILYCPVAFLTFSSLL 786
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1              ## ###  #  ##                     
gi 158519993 799 glfpvtPEAVKSVLLVVLPLPACLNPLLYLLFNphFRDDL 838
gi 395132309 801 gllslgEEVLKSVLLLLQPLPACLNPLLFLLFTrdHSHFF 840
gi 519882077 790 slfpvsEEVVKSVVLVLLPLPASINPLLYLLFNphFREDM 829
gi 483520037 655 nlflitPEVIKSVLLVVLPLPACLNPLLYLLFNphFRDDL 694
gi 556976020 784 nlfqisPEVIKSILLVVLPLPACINPLLYLLFNphFKDDL 823
gi 632953361 787 nlflisPEVIKSILLVVLPLPACLNPLLYLLFNphFKEDL 826

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