Conserved Protein Domain Family
7tmA_GPR4

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cd15366: 7tmA_GPR4 
proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.
Statistics
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PSSM-Id: 320488
View PSSM: cd15366
Aligned: 6 rows
Threshold Bit Score: 403.021
Threshold Setting Gi: 512860035
Created: 15-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #  ##            ###### #
gi 1708027    18 LFPPSLYIFVIGVGLPTNCLALWAAYRQVQqrnELGVYLMNLSIADLLYICTLPLWVDYFLhhdNWIHGpgSCKLFGFIF 97
gi 47221039   16 FFQPTLYIIVIVLGLPTNCMALWAAYMQVRqrnELGVYLINLSVADLLYIATLPLWIDYFLqrdDWIHGqeSCKLFGFIF 95
gi 591351816  18 LFPPTLYIMVITMGLPTNCMALWAAYLQVRqhnELGIYLLNLSVADLLYIATLPLWIDYFLhydNWIHGqeSCKLFGFVF 97
gi 556963347  19 LFPPILYIIVIVIGLPANCLALWAAYLQVRqknELGIYLINLSVSDLLYIGTLPLWFDYFLhhdNWIHGqeSCKFFGFIF 98
gi 632992111  18 LFPPTLYIFVMVIGFPTNCLSLWAAFVQVRqknELGVYLLNLSISDLLYIATLPPWVNYFLhqdNWIHGpeSCKLFGFIL 97
gi 512860035  18 VLPPSLYALVFTLGLPANLLALWAAWLQVRkgrELGVYLLNLSLSDLLLICALPPWTDYYLrrdVWGYGpgACRLFGFVF 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 1708027    98 YTNIYISIAFLCCISVDRYLAVAHPlrFARLRrvKTAVAVSSVVWATELGANSAPLFHDelfrDRYNHTFCFEKFPMe-g 176
gi 47221039   96 YTNIYVSIAFLCCISLDRYLAVAYPlrFAKVRrvKTAVLVSSIVWIIEIVANSAPLFHDelfqDRFNHTFCFEKYPMq-d 174
gi 591351816  98 YTNIYISIAFLCCISVDRYLAVAHPlrFAKVRrvKTAVAVSAVVWAIEIGANSVNELFH----HRYNHTFCFEKYPMe-e 172
gi 556963347  99 YTNIYISIAFLCCISVDRYLAVAHPlkFAKIRqvKTAIVVSLVVWTIEIGANSVPLFHNelfsDRFNHTFCFERYPMe-y 177
gi 632992111  98 YTNIYISIGFLSCISVDRYLAVAHPlkFAKVRrvKTAAVVSAVVWAIEIGANSAPLFHNelfeDRFNHTFCFEKYPMe-d 176
gi 512860035  98 YTNLYVGAAFLSCVSADRYLAVAHPlrFPGARpiRSAAAVSALIWMLELAANAPPLLGEaihrDRYNHTFCYESYPLsgr 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### ### ##                                              #  ## ##  #         
gi 1708027   177 WVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRgsvsterQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPW 256
gi 47221039  175 WVAGMNLYRTFLGFLAPWTAMLVAYRGILAAVRcnvsteqQEKAKIQRLALSLILIVLLCFGPYHILLLVRSVIFLRKPC 254
gi 591351816 173 WVAWMNLYRVFIGFLFPWVLMLFSYQGILRAVRgnvsteqQEKAKIKRLALSLIAILLFCFAPYHVILLSRSAVYLSKPC 252
gi 556963347 178 WVAWMNLYRIFIGFLFPWVLMLFSYHGILKAVRgnvstekEEKAKIKRLALSLIVIVLLCFAPYHMILLSRSVVYLCEPC 257
gi 632992111 177 WVAQMNLYRVFVGFLFPWVLMLFCYQGILRAVKtnvsterEEKAKIKRLALSLIAILLFCFAPYHLILLSRSVVYLGQPC 256
gi 512860035 178 GAALANVGRVLAGFLLPWGVMMLCYAGLLRALRgsasceqRERRRVRRLALGLPCVALLCYGPYHALLLLRSLVFLVGGG 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                     ## ###  #  ##                     
gi 1708027   257 DCgfe------erVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDV 297
gi 47221039  255 DCgse------esLFAAYHVSLALTSLNCVADPILYCFVNEGARHDV 295
gi 591351816 253 DCsfe------ekVFVAYHSSLAFTSLNCVADPILYCFVNEGARSDV 293
gi 556963347 258 DCrfe------enVFTAYHISLAMTSLNCVADPILYCFVNESARNDV 298
gi 632992111 257 DCtfe------enIFTAYHVSLALTSLNCVADPILYCLANEGARSEV 297
gi 512860035 258 SVdagggcaleerLFPAYHASLALATLNCLADPALYCLACPGARGEV 304

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