Conserved Protein Domain Family
7tmA_PAR3

?
cd15371: 7tmA_PAR3 
protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors
Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.
Statistics
?
PSSM-Id: 320493
View PSSM: cd15371
Aligned: 5 rows
Threshold Bit Score: 383.762
Threshold Setting Gi: 118103904
Created: 19-Nov-2008
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##     #      ###### ##
gi 3024351    95 KLIPAIYLLVFVVGVPANAVTLWMLFFRTRsicTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEvLCRATTVIFY 174
gi 118103904  94 KLIPTVYLSAVLLGVPSNAIILWMLLFRIRsvcTAILYTNLAVSDLLFCIMLPFKIAYHINKNNWIFGEiMCRTTTVVFY 173
gi 148227652  98 ALIPGIYIIVVLIGVPANAIVLWMLFHQVTsvcTTVLYASLATSDLLYCLMLPFKIVYHLTGNNWIFGEtMCRTMTIFLY 177
gi 556966782  84 MLIPAVYIIVTVLAVPLNIIILCMLFRHSGyvcTAIFYANLAISDLLFCITLPFKIVYHLHGNNWMLGEtVCKIITINFY 163
gi 632974241  66 TFIPAVYTTVLMLGFPSNAIALWMFCSKLRtipTAIFNINLVISDLSFLATLPFIIHQYINGNNWVFGEaTCRIITATYY 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                                            # #####                ###       
gi 3024351   175 GNMYCSILLLACISINRYLAIVHPFtYRGLPKhTYALVTCGLVWATVFLYMLPFFILKQEYylvqpdITTCHDVHntces 254
gi 118103904 174 GNMYCSILLLTCISVSRYVAIVHPFtYKSLPKrTYAIAVCATVWTIVFLYMLPLCIMQQSYyvkqlgIYTCHDVQsacet 253
gi 148227652 178 FNMYCSILLLMCFSISRYVAIVHPFiYRSLPKgTYTVLLCLLVCTIALVYMIPFFITRQTYhlkelnITTCHDVYdvs-- 255
gi 556966782 164 GNMYCSVLFLMCISINRYMAIVHPFiYRHLPKqTYTVLGCILVWVIIFIFMIPFSLVKQQFqipkanVTTCHDVLhrne- 242
gi 632974241 146 GNMYSSIFFLTCISINWYLAIVHPFlYKDLPKkNIAGYICATIWLVVFLFTLPIVLLKQTYffkelnIVTCHYVLpeetq 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #  ### ### ##                                          #  ## ##  #          
gi 3024351   255 sspFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLnaydHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYyynNTD 334
gi 118103904 254 vssFQFYYYVSLAIFGFLMPLAIIIFCYISIIRTLk--tHEWFWYVKVSLLILTIFAICFVPSNIILIIHHINYyyyNTD 331
gi 148227652 256 gdaFQFYYFISMVVFGFLIPFSVVAFCYFSIIRALtaneQKRFWYVKITVLFFIIFALCFTPSNLILLIHQVRYhhsHND 335
gi 556966782 243 qfyFSFHHQILMPVFGFLIPLVVTTFCYISIIRTLnqyeEKWFWYIKITALVLIIFTVCFTPSNVILITHFFYYyttNND 322
gi 632974241 226 ntnLFFYYLTFYIVCGFVIPLIITLFCYTLVIKTLhglnAKWVGYIHIAAVVLMTFVICFAPSNVILLIHNFKQd-fTGD 304
                        250       260       270
                 ....*....|....*....|....*....|....*...
Feature 1         ## ###  #  ##                        
gi 3024351   335 GLYFIYLIALCLGSLNSCLDPFLYFLMS----KTRNHS 368
gi 118103904 332 NLYSFYLIALCLSSLNSCLDPFLYFLMS----KIRSQS 365
gi 148227652 336 DMYGIYLMALCLTSLNSCLDPFLYFLIY----KKVNAS 369
gi 556966782 323 IFYKHYTVSLCLTSLSCCLNPFLYYLMSrfgnKFNSYQ 360
gi 632974241 305 NLYSLYLTALCLGSLNTCFDPFLYYYTYfy-sKWKAQS 341

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap