Conserved Protein Domain Family
7tmA_P2Y11

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cd15376: 7tmA_P2Y11 
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors
P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).
Statistics
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PSSM-Id: 320498
View PSSM: cd15376
Aligned: 9 rows
Threshold Bit Score: 412.552
Threshold Setting Gi: 632984378
Created: 25-Nov-2008
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:partly based on the structure of human P2Y1 receptor with bound nucleotide antagonist MRS2500
  • Comment:also based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ###### 
gi 21263830    29 DFLWPILVVEFLVAVASNGLALYRFSIRKQrpWHPAVVFSVQLAVSDLLCALTLPPLAAYLYpPKHWRYGEaACRLERFL 108
gi 147902728   16 TFLAPMYGVAFVVSVLGNSLAIWLLGPGSSknRHAGIIFSLNLAVSDLFYSLSLPLLVAYYTmNKNWVFGLaMCKVERFV 95
gi 632984378   18 AVLPPLLGVECVLALAGNSLAVWLFVCRVArpWHSGTVLAFSLALSDLLYAASLPLLIAYYAsGKSWRFGQsLCRAERFL 97
gi 557010399   17 DFLPPVFGIEFLLALLGNSLAMWLLYTREKt-WHTGIIYAFNLAVNDLLYVLSLPLLMVYYLnNKDWIFGNvVCKLERFL 95
gi 641783765  698 EHMWPAVTVEFFLAFAGNAFAIYRFVARERt-WHTGIVYSFNLAVSDLLYALSLPFLAAYYYpPKHWRYGLaLCKLERFL 776
gi 573887754  415 GFLPPVFGIEFCLAFPGNVLALWLLLTRERrnWHTGVVFSFNLAVSDLLYVLTLPLLVIYYLgEKEWIFGEaTCKIERFL 494
gi 565312156  549 EKLWIIIILQFFFAVLGNGFTIYHFVAWERs-WHPGIIFSFNLALSDLFYTISLLPLAVYYFpPKDWRYGCpFCKLDRFA 627
gi 325053654   15 DLLPPMYGIEMTVALLGNIFALWLLGTRERkdWHTGVVFSCNLAISDVLYILTLPLLIIYYGkKKNWTFGDaVCKIERFL 94
gi 537178882   56 GYLWAILMAEFLVAVGGNGLALFRFITQEQrpWNPAVVFSAQLAVSNLCYSFTLPPLAAYFYpPKNWSFGEvACRLERFV 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                        
gi 21263830   109 FTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRpKHAWAVSAAGWVLAALLAMPTLSFshlkrpqqgagncsvarpeaC 188
gi 147902728   96 FNCNLYGSIFFITCISANRYLGIVFPFYTRGRVEsKHAKWVSLGVWVLVAAISAPVFLFsklq------------vennK 163
gi 632984378   98 FTCNLYGSILFITFISLNRYLGIVRPMLARAHVRpGRAKLASLAGWLLTAAITGPTLSYsqle------------erhgK 165
gi 557010399   96 FTCNFYGSIFFVTCISFNRYIGIVHPFFSHGKVHpKHAKMVSLAVWVLIFTSSTPVLFFsttdvt---------keqknK 166
gi 641783765  777 FSCNLYGSIFFLTCISLNRYLGIVHPLLVHGRLEpRHAKLLSGAGWLLVAGLSTPTLHFselq------------prgnC 844
gi 573887754  495 FTCNLYSSIFFITCISVNRYVGIVHPMFTHSHVRpKHAKLVSVGVWALVTVLSCPVLKYaaltk-----------gernN 563
gi 565312156  628 FFVNLYGSTFFIACISLNRYVAIVHPFFAHERVEsFHAKVVSGVIWLLAIAISAPVLHFsave------------skgnA 695
gi 325053654   95 FTSNLYVSIFFIMCISVNRYIAIVYPFFTRSYVRpVHAKIASVLVWFIVIITSSPVFSFagtevve-------sdrvhnR 167
gi 537178882  136 FTCNLLGGIIFITCISLSRYMVVVHPFFTRRHLRpKHAWVISAASWAMAILLAAPMLGFshqnqpqskpgscnntnreaC 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # ###        #  ### ### ##                                              #  ## #
gi 21263830   189 IKCLGTAdhg-laaYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLrspgMTVAEKLRVAALVASGVALYASSYVPYHIM 267
gi 147902728  164 TECLGTAvnselpsYFPYSLFLAGFGCALPFLITFLSYIGIAKAVWkshgLEPREKRKVVTLVCVVVLLYAISFVPYHIL 243
gi 632984378  166 LQCLGTAvdarlagYLHYSLFLAVWSCALPFLVTLSCYLSVVRAVWaspsVERAERHRVLALVLVVLSLYGVSFLPYTVL 245
gi 557010399  167 TECLGSSandmlytYFPYSLSMAVLGCGLPFLITLASYVAIFWTVFknetISMLEKKKIAYMITIVVILYAVSFLPYSIL 246
gi 641783765  845 TECLGSAtdeqlphYLPYSLFLAAFGCGLPFLLTLFSYAAILRTVCrnphITWLEKRKVGRLVSVGVALYAVSYLPYHTL 924
gi 573887754  564 TECVSFDhkd--ktYFVYSVFLATVGCLVPFLATFASYFAILWVVWknqnITPLEKRKVAAMIALVVVLYAVSFIPYHVL 641
gi 565312156  696 TVCLGSAsvselpvYLSYSWFLLAVGCGLPFLLTLFSCVAIVCAVRrshgTTREEKCKVKILVSIVVLLYALFYLPFHVF 775
gi 325053654  168 TLCVSCKdksraksHLKYTLFLMVVGCMIPFLVTFASYLGVIWTVLknknITTLEKRKVALMVALVCILYATSFVPYHFL 247
gi 537178882  216 VKCLGMMedsqietFRNYSLVLACLGGILPLLLTLMAYSALGSVVLrslsMTTAQKLHVVVLVTSGVALYACSYVPYHIT 295
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1         #  #                           ## ###  #  ##                         
gi 21263830   268 RVLNVdarrrwstrcpsfadiaqataalelgPYVGYQVMRGLMPLAFCVHPLLYMAAVp---sLGCCCR 333
gi 147902728  244 RNLNLknriats------------dckwslkIHSAFQVAKALVSLNPCIHPLLYTAVIdnvraKLGCYQ 300
gi 632984378  246 RNVNLyrrlhgl-------------dqaaggIYKAYQVSKGLVTLNACLHPLLYAALPeh-akALCCPG 300
gi 557010399  247 RNINLyrrmkcf------------lpessldIHKAYQVTKGLVTLNMCIHPLLYASVAts--iRSICRR 301
gi 641783765  925 RNLNLhlrqqcllgk-------aphyqhalfVHSAYQLSKILVTLNICAHPLLYGALAds--mRGWCRA 984
gi 573887754  642 RNVNFfnrvfd--------------tyssrrLYQSIQVTKGLVTLNMCIHPLLYMTVFds--iRTICCG 694
gi 565312156  776 RNVNLyyrvqd---------------nanraIYFTYQITKILVNFHVCIHPFIYAALAkn--mPKCCCK 827
gi 325053654  248 QTYHVylksen---------------lkecwLYNSYQVSKGLATLNMCLHPLLYMAVFds--iRTVCCG 299
gi 537178882  296 QVLYVnsllswkalcpgfstesqakaalnprAFFGYQTTRILVPLATCMHPLLYMAVAps-lnCHSCHG 363

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