Conserved Protein Domain Family
7tmA_BK-2

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cd15381: 7tmA_BK-2 
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors
The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.
Statistics
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PSSM-Id: 320503
View PSSM: cd15381
Aligned: 5 rows
Threshold Bit Score: 435.736
Threshold Setting Gi: 632986322
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some angiotensin receptor family (class A) members with bound ligands (agonist peptides or chemical compound agonists/antagonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligands, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                                                #  ##   #            #  #
gi 2506481    58 TIQPPFLWVLFVLATLENIFVLSVFCLHKSsctVAEIYLGNLAAADLILACGLPFWAITIsnnFDWLFGetLCRVVNAII 137
gi 71895971   53 TFQPGFLWIIFILGTIENAFVLIVLYFHKSrcsVAEIYLANMAFADLMLVCSLPFWAINIsngFQWPFGlfLCKAVNTIN 132
gi 632986322   3 MAQPIYIVLICAVGMVGNAFVLLVLVLHRVsctVAEIYLGNLAAADLLFVGCLPFWAANIvngYNWPFGefLCKSVSAVI 82
gi 512861082  45 SFQPIYMWIVFVLGFIENMFVLIVFLLHKKrctVAEIYLGNLAAADFLLVCGLPFWAIYIsnkFHWPFGsfLCVFINGLI 124
gi 557017625  39 TLQPIYLWIISVLGIIGNTVVLSVFCLHKKgctVAEIYLANLAAADLVLCCCLPFWSIYIanhFNWPFGqfLCQTVSAVI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                                  #   #                #    
gi 2506481   138 SMNLYSSICFLMLVSIDRYLALVktMSMGRMRgvRWAKLYSLVIWGCTLLLSSPMLVFRtmkeysdeghnvtACVISYPs 217
gi 71895971  133 YMNSYSSIYFLTLVSIDRYLALVktMSLGRMRrtACAKWNSLIIWMCALLICSPTMVFRnlqyfk--eynitACSLDYPt 210
gi 632986322  83 YMNLFCSVYLLAMVSIDRYLALVhtMTSGRTRspACAKMTCLAIWAFGFLMSTPVILFRtvmakp--eynisACLLRYPs 160
gi 512861082 125 QLNLYGSIYFLMMVSIDRYLALVktMSFGRMRtgRCAKLNCLLIWIFAVVSSMPKTIFRriryfp--efnvtACVIDPPs 202
gi 557017625 119 YINLYSSLYFLVMISIDRYLALVrtMSIGRMRrsCYAKIICLIIWMFGVLMSTPMIMFRsvsyip--nynitACILKYPn 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         #  #           
gi 2506481   218 liWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRnnemqkfkeiQTERRATVLVLVVLLLFIICWLPFQISTFLDTLhr 297
gi 71895971  211 pyWHPANNCLLNAVGFMIPLCIITYCTTQIIKALQsnksqklkliQTERKATLLVLAVLLLFVICWLPFQISTLIDTVcy 290
gi 632986322 161 egWSLNLEILLLVFAFIVPGSIITFCSCQILQVLRnntmrqfmqvRKETKSSKLVLLVLLMFFLCWLPFHFFTFLSILqk 240
gi 512861082 203 psWNVASGLLLTLVGFLIPVTVISYCSFHIINVLRnnsmqefkeiNKEKKASVLVLVVLLVFIICWLPFHITTFIDTLhm 282
gi 557017625 197 enWHFAINILLNIVGFLIPLAIITFCSTCIIITLQnnkmkkfkavQTEKKATNLILAVLLMFFICWMPFEVFTFLDTLfv 276
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
Feature 1                            #   #                     
gi 2506481   298 lgilsscqderIIDVITQIASFMAYSNSCLNPLVYVIVGkRFRKKS 343
gi 71895971  291 lagn-lkcledINDIVTQMAIYCAFSNSCLNPILYVIVGkHFQKKA 335
gi 632986322 241 lglipgcrweaVLENGNQITTFLGFTNNCINPLLYVIVGkHFRKKA 286
gi 512861082 283 mnlfsscamnnFIEIASQISSYLGYSNSFINPLLYVMVGnHFRKKV 328
gi 557017625 277 gkvisgctwedLLDIGSIISTFVAYSNSFLNPMLYAIAGkHFRTKA 322

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