Conserved Protein Domain Family
7tmA_AKHR

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cd15382: 7tmA_AKHR 
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.
Statistics
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PSSM-Id: 320504
View PSSM: cd15382
Aligned: 14 rows
Threshold Bit Score: 414.786
Threshold Setting Gi: 158593876
Created: 2-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #  ##          ######
gi 112983116  42 MVSMTVYSVLMVISATGNLTVLYQLVRRRRAKrasrLDILLMHLAVADLMVTFLMMPLEIAWAGtvqWFAGDlmCRVMMF 121
gi 158593876  21 YFTFXCYSICFCIAFIGNGTMFLILIRNQRVKvr-rVHTLLLHMNIAHLIVTLIYMPKEVIHSItvaWWGSDflCRICKF 99
gi 70910044   24 AHSIISLGVVFLIGALGNIASFVTLLCSKNRKs--pTNFFLLHLSSADLLVMFVIPVGEMIHNAtiaWLGGNflCKLYHF 101
gi 443690008  43 IVSVSILGVMFLVAAVGNLTVFAILFFNRHSRls-rVSIFIMHLSISDLIITFIMIPMEIGWHVtvaWKAGDvgCRVLLF 121
gi 170029979  11 VAVIIVYCVLFIIAAGGNLSVVITLFRSRRHRrs-rVSLMICHLAVADLMVAFIMIPLEVGWRItvqWHAGNvaCKVFLF 89
gi 242346723  51 LTIIIVYCICFLVAAIGNLTVFLTLWRGRYRKs--rISLMICHLSIADLLVAFFTIPIEIGWRLtvqWIAGNyaCKLFLF 128
gi 443703272   8 LISVIAYCILFLIAACGNLTVFITLYRNRHRKs--rVNLFIMHLSVADLIVTFIVLPLEVTWHItvaWYAGDaaCRIIMF 85
gi 134053892  53 QLSIIVYSILMVFSAIANTTVLVLIVKRRRKTps-rINTMLMHLAIADLLVTFLMMPLEIGWAStvsWYAGDamCRIMMF 131
gi 22901736   39 RLSITVYSILFVISTIGNSTVLYLLTKRRLRGpl-rIDIMLMHLAIADLMVTLLLMPMEIVWAWtvqWLSTDlmCRLMSF 117
gi 195947028  50 GPVLATYAILLAIGGVCNIAVLVKLAKPRRRKs--rVDMLMTHLALADVCVTCGVIPLEIGWKYtnaWLGGNflCKLLLV 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                           # #####                        
gi 112983116 122 TRTFGLYLSSFVLICIAVDRYYAILKPLnvt--weaTVRRAIIVAWVCAGLASLPQSFIFhv------eeHPEVKGYNQC 193
gi 158593876 100 FDNFGNSLAANMLICISLDRFYSIFSPLytln-akkSIQRMIAVAWIISFVISIPAVWSYlqaalfrtssHPCAKWFIQC 178
gi 70910044  102 LWNFGQYVATFLLCCISIDRYLAFVFPLrsltqsprTRSFMAATAWVLSAILSAPESVIFhv------etHPKYRTFRQC 175
gi 443690008 122 FRAFGFYLGSFILVAISLDRYLSITKPLslvd-agkRGRIMLRFSWLFAFVAAIPQSIIFhv------eqHPIHTWFSQC 194
gi 170029979  90 MRAFCLYLSSNVLVCVSLDRCFAVIYPLrvsa-arkRGKIMLGGAWFIAFANALPQSIIFrv------qqHPQVPGFTQC 162
gi 242346723 129 LRAFGLYLSNNILICVSLDRYFAVLYPLrvnd-arrRGKFMLSVAWFFSVLYAIPQSIVFhv------enHPHHKNFTQC 201
gi 443703272  86 FRAMGFYLSSFILIAISLDRYFAILHPLslnd-adkRSKLMIIFSWAFSVIASIPQSIIFhv------eqNPTYSWFSQC 158
gi 134053892 132 FRMFGLYLSSFILVCISVDRFYAVLKPLylra-ldrRDKFMLLGAWLGATLCSIPQMVVFhv------esHPNITWYQQC 204
gi 22901736  118 FRVFGLYLSSYVMVCISLDRYFAILKPLkrs---ynRGRIMLACAWLGSVVCSIPQAFLFhl------eeHPAVTGYFQC 188
gi 195947028 128 LRAFGLYLSSNVLVCISIDRFFAVIYPLrlpe-akrRSRQMLYCAWVGALACSLPQSMVFrv------khHPRVIGFEQC 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  ### ### ##                                                      
gi 112983116 194 VSYgslp--tekHEFAYFLVNMILMYVIPLVSTLYCSCAALFEIirrantandk----------------------mrrs 249
gi 158593876 179 VSGdfvgavshdVVFAYTIANLTQVSLLPLIITVICYSFILYKIssksetkvlstrqvnstkl-----nfigisttklrt 253
gi 70910044  176 VTFnffp--shnHELAYNLFNLITLYALPLLIITTSYSLILWEIskktkqckeetkcls-------------trsrlrrs 240
gi 443690008 195 VTFnffp--sdqHEMAYNVSTVCMMYVVPLLLITACYSLILREVskktsstrtvsggq--------------crvrmsgn 258
gi 170029979 163 VTFgffr--tpgMETAYNLFCVIAMYFMPLMIISAAYTVILCEIsnrsreketsdtsht-------------ggmrlrcn 227
gi 242346723 202 VTFgafp--sdlVENTYNVFCVLTMYFIPLAIICWVYLKILCEIssksrdnkpvvikagsngtlessnsnqgsrmrlrrs 279
gi 443703272 159 VTFnffp--segHELAYNMFNMITVYALPLVVIIVSYSLILCEMtrktresqedvkapsk----------mnaserlrrs 226
gi 134053892 205 VTYnvfp--tyaHELTYLLFGMVMMYALPLAVIIFSYASILLEIrrrtrnpygds---------------------vtrs 261
gi 22901736  189 VIFnsfr--sdfDEKLYQAASMCSMYAFPLIMFIYCYGAIYLEIyrksqrvlkdvia-----------------erfrrs 249
gi 195947028 201 VSFdafn--syeQEVAYNVFCMCAMYFLPLIVITVCYVCIFCEIrksskelgdkyhsgl-------------kpvrlrrs 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #  ## ##  #          ## ###  #  ##                    
gi 112983116 250 gigllgRARARTLKMTVTIVLVFFTCWSPYYCYCLWYWIdkesiknlDPALQKAMWLFSCTNSCANPIVYGVFNrNRWNW 329
gi 158593876 254 sgetytRAKSKTLKMTFVVVFAFLLCWTPYAVASLVHFTikp--spiPAIIRKLLYTFAVFNSAISPYLYGYFS-FDLKR 330
gi 70910044  241 svgnmeRARIRTLKMTLVIVSVFVICWTPYFVLSAWWWFdsdsasqlDPKVQRGLFLFAVSNSCMDPIVYGMFT-TTFRR 319
gi 443690008 259 grlkmaKARTNTLRMTIVIVLVFVICWSPYFCMLLVWWIdrgqavkvPPKLQRAIFIFAVSNSCVNPFVYGTCShIYING 338
gi 170029979 228 dlthieRARQRTLRLTITIVVVFVWCWTPYVVMTLWYMFdresaikvDGAIQDGLFLMAVSNSCMNPLVYGSYA-MKCRW 306
gi 242346723 280 dmssieRARSRTLKMTIIIVVAFIFCWTPYITMNLWYVIdkksakevNEMVQESLFIMAVGNSCANPLVYGSYA-IDLKK 358
gi 443703272 227 nvghiqRARIRTLRLTIMMVLVFILCWTPYFVMSSWWWFdrssaakvDPRIQKGLFLFAVSNSCMDPIVYGKPCiRDTPP 306
gi 134053892 262 slaflgKAKVRTLKMTIIIVLVFFVCWTPYYVMCIWYWLdresaknvDQRIQKALFLFACTNSCMNPVVYGVFN-IRARR 340
gi 22901736  250 nddvlsRAKKRTLKMTITIVIVFIICWTPYYTISMWYWLdkhsagkiNPLLRKALFIFASTNSCMNPLVYGLYN-IRGRM 328
gi 195947028 266 drslleRARRRTLRMTVTIVSVFALCWLPYAIMAMWYMVdresaskvSRRIQDLLFAMAVSNSCMNPLVYGSYT-LDIRG 344

                 ..
Feature 1          
gi 112983116 330 RA 331
gi 158593876 331 EL 332
gi 70910044  320 ET 321
gi 443690008 339 AS 340
gi 170029979 307 PW 308
gi 242346723 359 EC 360
gi 443703272 307 RI 308
gi 134053892 341 TG 342
gi 22901736  329 NN 330
gi 195947028 345 AL 346

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