Conserved Protein Domain Family
7tmA_GnRHR_invertebrate

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cd15384: 7tmA_GnRHR_invertebrate 
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in nuemerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.
Statistics
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PSSM-Id: 320506
View PSSM: cd15384
Aligned: 6 rows
Threshold Bit Score: 433.402
Threshold Setting Gi: 84095064
Created: 2-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                        #  ##          #
gi 84095064   32 VSKLCVLGTVFVISFFGNTLVIIQIFRIRGSRs-------tIQSLILNLAIADLMVSFFNILMDIIWSAtveWLAGNtmC 104
gi 225030853  59 LTKIVTICILFVIAAIGNLFMARATLRLRRRSg--------IYLLLLHLSVGELLVTCITMPSEAIWAYtvsWWAGDtmC 130
gi 184161263  61 MAKIIIVVVTFVLSFVGNVTFLITSWRLRRNRra-----rpLQSLLVHLAIADLIVTLVTMPSLGIWFYtvaWLAGNgmC 135
gi 307206489  77 YLKVIILAVISVLSLLCNLATIYSITKNRRKQrg-----stIYTLLLHLTIADLLVTVFCLAGEAIWSYnvaWLWGNaaC 151
gi 20385582  119 LLKVYVLAVMALFSLLGNLLTIWNIYKTRISRrnsrhtwsaIYSLMFHLSIADVLVTWFCIIGEAAWCYtvqWLANEltC 198
gi 443692025  72 MIKTVVLSCMFVVAFIGNTATLVQMYRMRRRKs-------tINLLLLHLAIADLLVTFFCIVSEAVWAStiqWFAGNfmC 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##### ##  #                                          # #####                    
gi 84095064  105 KIMKYLTVFGLHLSTYITVSIALDRCFAILSPmsRSKAPlRVRIMITMAWVLSAIFSIPQAVIFqeqrkmfrqgmFHQCR 184
gi 225030853 131 RIVKYGQMLGLYLSTYITVCISLDRCVAIAFPlkKGQAPeRARSMVIVSWALSPIFCIPQAVIFhvevh-qyvpsFHQCV 209
gi 184161263 136 KLIKSLQVLGLYLSTYLTVAISIDRCISVVKPmcRNTAK-RRRNMVAVCWILSTIFSIPQAVIFhves---pvpdFQQCV 211
gi 307206489 152 KFFKFLQMFSLYLSTFVLVLIGVDRFVAVRYPmkGLSMNqKCSRFVLFAWILSCILALPQIAIFhvaqg-pfvevFTQCV 230
gi 20385582  199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPmkSLNMAkRCHRLLGGTYILSLVLSLPQFFIFhvarg-pfveeFYQCV 277
gi 443692025 145 KLVKFLQVFGLYLSTYIIVIIALDRCLAILDPmsRNRAPrRVRTMITVAWIMAGFFSTPQIIIFkverg-pfpedFFQCV 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                                         
gi 84095064  185 DSyn--alWQKQLYSASSLILLFVIPLIIMVTSYLLILKTIvktsrqfhdtpisptsmscysvnhgqirthLFERARKRS 262
gi 225030853 210 TYnfysaeWQEDLYNMLVFVVMYPAPMVIMVACYVCIFVSLfrhwrgtnnle---------tgnktgqrerLFSKAKVRT 280
gi 184161263 212 TFgfytakWQEQLYNGLVLVVMYPIPLLVILICSVLTFIRLkkegqdkdtf-----------rtrnptrqrLLLKARNNT 280
gi 307206489 231 THgfyteaWQEQLYASFSLFFMFLLPLAILITTYVSTVITLsrsqrmfkgeltnn---gmytrssdlnrrrLMHRAKTKS 307
gi 20385582  278 THgfytadWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTIsssekmfqgsklan--ystaklptqtnrqrLIHKAKMKS 355
gi 443692025 224 TYgtysqpWQEQLYSCLSVGFMFIIPLVAMVSAYMLIFHTIakksrdfqraas-------dmlsrgpvrgqLFRKAKVKS 296
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                      #  ## ##  #         ## ###  #  ##                      
gi 84095064  263 SRMSAVIVAAFILCWTPYYIIFLGFAFfq---wdNSRTVIYFFTLGTSNCMLNPLIYGAFTiYKVHRGR 328
gi 225030853 281 LQMAAGILTTFFVCWTPFYCVMMWHLFfqheypiNQIIFDVLYPFGVSNACVNPVVYGKSVvTRKPGKS 349
gi 184161263 281 LRTTAGIMTSFILCWTPYFVTLVWILFfnw-qtvSPVVFDVLFLFGIFNSCVNPIVYGLSMfKKTTARP 348
gi 307206489 308 LRISVVIVAAFLIWWTPYYTMMIIFLFlnpdehlSDELQSGIFFFGMSNSLVNPLIYGAFHlWPQKQQK 376
gi 20385582  356 LRISVVIIIAFLICWTPYYVMMIMFMFlnpdkrlGDDLQDAIFFFGMSNSLVNPLIYGAFHlCPGKGGK 424
gi 443692025 297 LRMTAVIVVAFIVCWTPYFVILILHTFssn--klDEKSSLWIFFFGMANSMINPLIYRAFQiSKNRKRK 363

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