Conserved Protein Domain Family
7tmA_V1aR

?
cd15385: 7tmA_V1aR 
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors
V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.
Statistics
?
PSSM-Id: 320507
View PSSM: cd15385
Aligned: 6 rows
Threshold Bit Score: 537.867
Threshold Setting Gi: 556993018
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##          ###### #
gi 33578087   60 KIEIAVLAVIFVAAVLGNCSVLLGLYKSKKKmsrMHLFIKHLSLADLVVAFFQVLPQLCWEItyRFYGPdfLCRIIRHLQ 139
gi 586197     52 KLEIAVLAVTFAVAVLGNSSVLLALHRTPRKtsrMHLFIRHLSLADLAVAFFQVLPQMCWDItyRFRGPdwLCRVVKHLQ 131
gi 11131044   25 KMEITVLSVTFFVAVIGNLSVLLAMHNTKKKssrMHLFIKHLSLADMVVAFFQVLPQLCWEItfRFYGPdfLCRIVKHLQ 104
gi 529444959  67 RLEIAVLAVSFAVAVVGNGSVLLALRRTPRKasrMHLFIRHLSLADLVVAFFQVLPQLCWEVthRFHGPdgLCRVVKHLQ 146
gi 638262172  49 KTEISVLGIIFLVAVIGNLSVLMALYKTKKKmsrMHLFIKHLSVADLVVAVFQVLPQFIWDItyRFNGPdfLCRIVKHLQ 128
gi 556993018  47 KVEIAVLAAIFAMAVIGNSSVLLALYKTKKKasrMHFFIKHLSLVDLAVAFFQLLPQLCWDItgRFLGPdyLCKIVTHLQ 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                           # #####                          
gi 33578087  140 VFGMFASTYMLVVMTADRYIAICHPLkTLHQPtkRSYLMIGSAWIISFILSTPQYGIFylkd--lgdGVYDCWADFispk 217
gi 586197    132 VFGMFASAYMLVVMTADRYIAVCHPLkTLQQParRSRLMIAAAWVLSFVLSTPQYFVFsmievnnvtKARDCWATFiqpw 211
gi 11131044  105 VLGMFASTYMMVMMTLDRYIAICHPLkTLQQPtqRAYIMIGSTWLCSLLLSTPQYFIFslseiqngsYVYDCWGHFiepw 184
gi 529444959 147 VFGMFASAYMLVAMTADRYIAVCHPLkTLQQPtkRSYGMIAAAWALSLLLSTPQYFIFslsevergsQVYDCWAHFimpw 226
gi 638262172 129 VLGMFASTYMMVMMSVDRYIAICHPLkTLQQAtkRSYLMIITTWMGSFILSAPQSFIFslseietgsGVYDCWANFilpw 208
gi 556993018 127 VLSMFISTFMLLIMTADRYIAICRPLkTLQLSkkRPYVVVLIAWAVSFILSTPQYFIFsvrk-ieesEEYDCWANFvvpw 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### ### ##                                                                  
gi 33578087  218 GLKAYITWITISIFVVPVIILLTCYGFICYNIWRNIKCKtkrgetdrkrsn-------gllstsvssvrtISRAKIRTVK 290
gi 586197    212 GSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKtasrqskgaeqagvafqkgfllapcvssvksISRAKIRTVK 291
gi 11131044  185 GIRAYITWITVGIFLIPVIILMICYGFICHSIWKNIKCKtmrgtrntkdgm--------igkvsvssvtiISRAKLRTVK 256
gi 529444959 227 GPRAYITWITGGIFVAPVFILVTCYGFICYHIWRNVRGKtxxxxxxxxxxx-------xxlapcvssvktISRAKIRTVK 299
gi 638262172 209 GIKAYITWITVSVFIIPVLTLAACYICVCYNISKNVKYKttnnssesavkng-----litsgvnvsnvktISKAKIRTVK 283
gi 556993018 206 GTKAYVTWITISIFIVPVIILLTCYGSICYNISRNIKCKtrkdlndnalkk--------gllscvsnvkiMSQAKLKTVK 277
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                    #  ## ##  #           ## ###  #  ##                     
gi 33578087  291 MTFVIVTAYIICWTPYFTIQMWSVYadntnWIENENTVVTVSALLASLNSCCNPWIYMFFSgHLLQDF 358
gi 586197    292 MTFVIVTAYIVCWAPFFIIQMWSVWdpmsvWTESENPTITITALLGSLNSCCNPWIYMFFSgHLLQDC 359
gi 11131044  257 MTLVIVLAYIVCWAPFFIVQMWSVWdenfsWDDSENAAVTLSALLASLNSCCNPWIYMLFSgHLLYDF 324
gi 529444959 300 MTFVIVSAYVVCWAPFFTIQMWSVWdqrfpWVDSENTATTVTALLASLNSCCNPWIYMFFSgHLLQDC 367
gi 638262172 284 MTLVIVLAYIVCWAPFFSVQMWSVWdqkapKDDSTDTAFTLTMLLASLNSCCNPWIYMFFSgHLLSDV 351
gi 556993018 278 MTFVIVLTYIVCWAPFFTIQMLAVWvkhfeWEESVNPIVTITALLASLNSCTNPWIYMFFSgHLLKDF 345

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap