Conserved Protein Domain Family
7tmA_V1bR

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cd15386: 7tmA_V1bR 
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors
The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.
Statistics
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PSSM-Id: 320508
View PSSM: cd15386
Aligned: 7 rows
Threshold Bit Score: 557.105
Threshold Setting Gi: 379317115
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##          ###### #
gi 1351393    35 KVEIGILATVLVLATGGNLAVLLTLGRHGHkrsrMHLFVLHLALTDLGVALFQVLPQLLWDItyRFQGSDlLCRAVKYLQ 114
gi 1351392    35 KVEIGVLATVLVLATGGNLAVLLTLGQLGRkrsrMHLFVLHLALTDLAVALFQVLPQLLWDItyRFQGPDlLCRAVKYLQ 114
gi 24041509   45 RAEVGVLAAILLVATTGNLAVLLAVCRRGRklsrMHLFVLHLALSDLGVALFQVLPQMLWEVtyRFAGPDlLCRAVKYLQ 124
gi 556991965  65 KVEVGILAAILVMATVGNLGVLLAMYRIRKkmtrMHLFITHLGLTDLVVALFQVLPQLIWKVtyRFYGTDfICRTVKYLQ 144
gi 632962956  44 RAEISVLAAVLIVAVAGNLAVLTALCRMKRklsrTHLFVLHLALTDLCVALFQVLPQLCWEItyRFQGPDaLCRSVKYLQ 123
gi 146334859  46 KIEIAVLAVILAVTTVGNLVVLFAMYRIRRkmtrMHLFIMHLGLTDLVVAGFQVLPQMIWDItfRFVGSDlLCRAVKYFQ 125
gi 379317115  62 KVEIAVLATIFVVAMASNLGVLLAMYRMRKkmtrMHIFIMHLGFTDLVVALFQVLPQMIWEVtyRFVGPDfLCRVVRYMQ 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                           # #####                          
gi 1351393   115 VLSMFASTYMLLAMTLDRYLAVCHPLrSLRQPsqSTYPLIAAPWLLAAILSLPQVFIFslreviqGSGVLDCWADFyfsW 194
gi 1351392   115 VLSMFASTYMLLAMTLDRYLAVCHPLrSLQQPgqSTYLLIAAPWLLAAIFSLPQVFIFslreviqGSGVLDCWADFgfpW 194
gi 24041509  125 VLSMFASTYMLMAMTLDRYVAVCHPLrTLRRPgrQPCAMVGAAWLLSCLLSTPQIFIFslrevqpGSGVLDCWADFgypW 204
gi 556991965 145 VLSMFASTYMLIMMTVDRYIAVCHPLkTLQQPtkQAYIMISATWFLSSILSIPQLFIFsltevdqGSGVYDCWAKFqlpW 224
gi 632962956 124 VVGMFASTNMLLVMTADRYLAVCHPLrTFQQPvrQVYVMIGAAWLLSCVLSLPQVFIFslrevdeGSGVYDCWAVFdvsW 203
gi 146334859 126 VLSMFASTYMLIMMTVDRYIAVCHPLkTLQQPsrQAYLMIGATWLISSLLSLPQIFIFslrevskGSGIIDCWAEFhfnW 205
gi 379317115 142 LLCMFASTYMLIMMTVDRYIAVCHPLkTIQQPskQANLMIAVTWLVSGALSIPQMFIFslkevkeGSCVFDCWATFefdW 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### ### ##                                                                  
gi 1351393   195 GPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNLKVKTQagreerrgwrtwdkssss--avataatrglpsrvssisT 272
gi 1351392   195 GPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQawrvggggwrtwdrpsps---tlaattrglpsrvssinT 271
gi 24041509  205 GARAYITWTTLCIFLLPVGILTACYSLICREICKNLKGKTQsctpvaggllaaspsapccsqkgsqcpsgqpsrvssvrT 284
gi 556991965 225 GAKAYITWTTLSIFIVPVAILIVCYSLICYEISKNLKYKTQtsvesgchsgp-----------------vmpsrvssvrT 287
gi 632962956 204 GAKAYITWTTASIFILPVLVLALCYSLICLEICRNLRWKSAgsegegrpgge-----------------mgpgrvssikS 266
gi 146334859 206 GAKAYVTWTTMSIFVIPVIVLVVCYSLITYEICKNLKGKTQtgrsengcyrg----------------qgmpsrvssvrT 269
gi 379317115 222 GIQAYITWTTLSIFVIPVAILIVCYSLICYEIYKNFRCKTQtrksknglqns----------------qlaasrvssvrS 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #  ## ##  #           ## ###  #  ##                       
gi 1351393   273 ISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDenapnedsTNVAFTISMLLGNLSSCCNPWIYMGFNs-------- 344
gi 1351392   272 ISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDknapdedsTNVAFTISMLLGNLNSCCNPWIYMGFNs-------- 343
gi 24041509  285 ISRAKIRTVKMTFVIVVAYVACWAPFFSMQMWSVWDedapddesADAAFTITMLLASLSSCCNPCIYMFFSg-------- 356
gi 556991965 288 ISRAKIRTVKMTFVIVFTYIACWSPFFSVQMWTVWDenspnedsSDFAYTINMLLASLSSCCNPWIYMFFSg-------- 359
gi 632962956 267 MSRAKIRTVKMTFVIVLAYVVCWSPFFSVQMWSVWDlaapddgsSNSLFTIAMLLANLNSCCNPWIYLVFSgnlrqsahr 346
gi 146334859 270 ISRAKIRTVKMTFVIVLAYVLCWTPFFSVQMWSVWDenapneesSDFAFTITMLLASLSSCCNPWIYMFFSg-------- 341
gi 379317115 286 ISRAKIRTVKMAFVIVLTYIACWTPFFSVHMWSVWDvnapkedsDDTAFTITMLLGSLSSCCNPWIYMAFSg-------- 357

                 ....*.
Feature 1              
gi 1351393   345 rLLPRS 350
gi 1351392   344 hLLPRP 349
gi 24041509  357 rPLQDT 362
gi 556991965 360 hLVHDV 365
gi 632962956 347 yLLPCQ 352
gi 146334859 342 rVLQDV 347
gi 379317115 358 hFIQDI 363

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