Conserved Protein Domain Family
7tmA_GPR83

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cd15389: 7tmA_GPR83 
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.
Statistics
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PSSM-Id: 320511
View PSSM: cd15389
Aligned: 13 rows
Threshold Bit Score: 406.724
Threshold Setting Gi: 443700967
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##           ###### 
gi 212276435  72 ALLIVAYSFIIVFSLFGNVLVCHVIFKNQRmh-saTSLFIVNLAVADIMITLLNTPFTLVRFvnstWIFGkgmCHVSRFA 150
gi 443700967   8 SVIMCAYSPLVLLSLCINFVVCYVLFKNRRmr-tvTNCFTTNLSISDILLTLLNIPFNVIRNtteeWVFGhviCGCTNFI 86
gi 84781789   73 IVLTFAYAVIIVISLFGNSLVCQVFVKHKEik-ksTGLLIFNLAISDILIILLNSPFALARFlsgqWVFGrimCHVSRFA 151
gi 56269543   72 ALLIVAYSFIIVFSLFGNVLVCHVVIKNKRmh-saTSLFIVNLAVADILITLLNTPFTLARFvnstWMFGkgmCHVSRFA 150
gi 347438925  72 ALLIAAYSIIIVFSLFGNVLVCHVIIKSKRlr-saTSLFIVNLAVADIMITLLNTPFTLARFvnstWIFGkgmCHVSRFV 150
gi 110626052  96 FWLVVGYTIVVFAAIIGNWVLNHIIMKYKRvh-taTGLFVVNISVTNMMLALLSSPFTMVRYlcnsLVFGkmtCHLSRFA 174
gi 405962071  46 LWLGLSFGILVLLSLCFNSLICCIIFRNKNlh-tvTNIFLANMAMSDILLVSINVPLNIVRNvtyeWTLGiilCKALTYS 124
gi 405960774  58 IILITAYAILICISLFGNSIVCYVIMRNRRmy-tvTNFFIANMAISDLFVTCLNVPFTIARNvldeWPFGdfiCHLVNFS 136
gi 321460054   1 AIIATAYALVMAISLFGNLLVCYVVFRHRRlqrsiTYTFLVNVALSDLLMTCLNIPFSVSRVlldhWPFGqflCSLVPFV 80
gi 332348542  55 VLVVVLYGLVVLVSVFGNTLVCHVVLRSRKmh-tkTNVLIANLAVSDLLMTTLTIPLSASRFlldnWPFGealCYLAPFL 133
gi 632937596  38 ALLIVAYSVIIVISLFGNVLVCQVVIKNKRmh-saTSLFIVNLAIADIMITLLNTPFTLVRFvnstWVFGkvmCHISRFA 116
gi 556960947  68 ALLIVAYSVIIVISLFGNILVCHVVIKNKRmh-saTSLFIVNLAVADILITLLNTPFTLVRFvnstWVFGklmCHVSRFA 146
gi 410928466  89 ALLVAAYSLIIAVSLFGNVLVCHVVLKKKRsp-saTSLFIMNLAVADIFITVLNTPFTLVRFvnstWVFGrimCHISRFV 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                           # #####                         
gi 212276435 151 QYCSLHVSALTLTAIAVDRHQVIMHPlkpRISI-TKGVIYIAVIWTMATFFSLPHAICqklftfky-------sedivrs 222
gi 443700967  87 LNVSVYASTFTMAAIALERYRVIMCPlrpRISF-CVASVTLVVIWLLGIIMSLPFAVFsevvevrf--------llhdtl 157
gi 84781789  152 QYCSLHVSTLTLMAVAMDRHRVILHPmkpRLTH-SQCLFVVAMIWSIAVFLALPHAIYqnlftlvn-------mdgdtrs 223
gi 56269543  151 QYCSLHVSALTLTAIAVDRHQVIMHPlkpRIST-VKGVAYIAIIWIMATCFSLPHAIYqklftfky-------seenirs 222
gi 347438925 151 QYCSLHVSALTLTAIAVDRHQVIMHPlkpRLPM-AKGVIYISVIWVMAACFSLPHAIYqklftfey-------seevtrc 222
gi 110626052 175 QYSCAYVTVMSMAAISLDRHRVMLYPlkaRITP-MQGNVCIIIIWIVSTCAALPHAVYqklyqvef-------gnttees 246
gi 405962071 125 IMVSSYVSTFTLTAIAFDRQRVLLHPlkpRMTK-QTGAAVIVVIWIMAFTLALPYGFFnsvremdi--------fvvkvt 195
gi 405960774 137 LMISVYVSTFTLTAIALDRQYVLLYPlkpRITK-RTGIVILVLIWVISFFLSLPYGIYtevtevsf--------vsrfvk 207
gi 321460054  81 QVMSVYVSSLTMAAIAVDRYRVILTPlkrRLRP-PHGLIIMAILWILASMAALPYALYsevvpiftyrlerktkkqmtfg 159
gi 332348542 134 QVTFVYVSTLSMTWIACDRYSVIVYPl--RLRHlCPGHRAVACIWALAGMLSLPHAVFnrvvslf---------tyrllv 202
gi 632937596 117 QYCSLHVSTLTLTAIALDRHQVIMHPlkpRMST-DKGVIYITIIWVMGCCFSLPHAIYqklfkfey-------siekirs 188
gi 556960947 147 QYCSVHVSVLTMTAIALDRHQVIMHPlksRMST-INGVTCIIIIWVMASCFSMPHAIYqklvrfey-------gnntvrt 218
gi 410928466 168 QYCSLHVSTLTLTAISLDRRQVILHPlrpRMTL-SQGGLWVTLIWIMASCFSLPHAIYqklltfty-------skekers 239
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  ### ### ##                                                      
gi 212276435 223 lCLPDFPepadlfWKYLDLATFILLYILPLLIISVAYARVAKKLwlcnmigdvtteqyfalrRKKKKTIKMLMLVVVLFA 302
gi 443700967 158 rCRVEYPqpqrtyERYIILTTFICQYVVPLLLTGVIYTHIVYKLwsremigqsierqqvahlKSRKRSIRMLVVVVLLFS 237
gi 84781789  224 yCLPSFPgpsilvSKYVDLGTFILLYILPLLVIVVTYSHLGKRLwiqnaigdasarqlmahyQKRKKSIRMLILIVLVFA 303
gi 56269543  223 lCLPDFPepsdlfWKYLDLATFILLYVLPLLIISVAYTTVAKKLwlrnaigdvtteqyfalrRKKKKTIKMLMLVVVLFA 302
gi 347438925 223 lCIPDFPepadlfWKYLDLTTFVLLYVLPLLIISAAYMTVAKKLwlrnvigdvtteqyfalrKKNKKTIKMLMLVVILFA 302
gi 110626052 247 aCLPSFPytskstWKYLDLGTFLLFFILPLLVLVAVYGHVAKKLwihdavddinihtyicqrGKKKQTLKMLMTVVLLYT 326
gi 405962071 196 rCRSAFPepkmkwEQYLTIATILVQYVIPLTIIGVAYVRIIHKLwlrnqlgyvtedqrlrqiRAKRKSIKLLIAVVMVFA 275
gi 405960774 208 rCRAVFPepkaefEMTLTLTTTIIQYFIPLTIIGFSYGRIVRKLwrrthlgavthsqqrsqnRAKRKSIKLLITVVVIFA 287
gi 321460054 160 rCQARFPtpalefRRYLTLITFATQYVIPLGISGLAYGAIVRRLwmrsfvgavtdnqrvrqdRAKRKTIQMLLVVISLFA 239
gi 332348542 203 rCQVQYPapsaefRRWLTLATFLTQYVLPLALTAYMYCRVSRTLwtrkalgaltreqqawhtRSKHKSLKMLVLVVLCFA 282
gi 632937596 189 lCVPDFPepadlfWKYLDLATFILLYVLPLLIITITYTMVAKKLwlrnaigdvtteqyfahrRKKKKTIKMLMLVVVVFA 268
gi 556960947 219 vCLHSFPqpadlfWKYLDLTTFVLLYVLPLLMILVTYTKVAKKLwmrnaigditmeqyyahrRKKKMTLKMLMLVVVVFA 298
gi 410928466 240 lCVPDFPepsdvyWQYIDLLTFILLYMLPLLIITASYTTVGCRLwrhnsigdtttaqyaaqrKKRRRTLTMLLLVVGVFA 319
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1          #  ## ##  #           ## ###  #  ##                     
gi 212276435 303 LCWFPLNCYVLLLsskv----irtNNALYFAFHWFAMSSTCYNPFIYCWLNenFRIEL 356
gi 443700967 238 ICWLPLNLYHILLnfhpdknlfvpNGNVYLSFHWLAMTSVCFNPLVYCWTKgaFRAEL 295
gi 84781789  304 VCWFPLNFYVVLIssag----venDSVLFYAFHWFAMSSTCYNPFIYCWLNrsFRAKL 357
gi 56269543  303 VCWFPLNCYVVLLssqt----irtNNALYFAFHWFAMSSTCYNPFIYCWLNdnFRSEL 356
gi 347438925 303 ICWFPLNCYVVLLssqt----irsNNALYFAFHWLAMSSTCYNPFIYCWLNdsFRAEL 356
gi 110626052 327 ISWLPLNVYLVLLsses----issHNGLYFFLHWLAISSSCYNPYIYCWLSdsFRIEV 380
gi 405962071 276 VCWMPLNLYHLLTdlhpntktfkyDSLAFFVCLWVAVSSTCINPFLYCWINphFRSRI 333
gi 405960774 288 LCWMPLNLYHILTdfhpdatvfryDSTVFFVFHWIAISSTCYNPFVYCWMNesFRKEV 345
gi 321460054 240 LCWLPLNVYHLVSdvgasesatrhNSTAFLVCHWLAMSSVCYNPFVYCWLNanFRDAV 297
gi 332348542 283 ICWLPLNVYHLVVhfrdhdgpdrhNSSLFIFFHWLAMSSVCYNPFIYCWLNdsFRRGA 340
gi 632937596 269 VCWFPLNCYVVLIssqt----irtNNALFFAFHWFAMSSTCYNPFIYCWLNesFRSEL 322
gi 556960947 299 VCWFPLNCYVVLMsska----isiNNALYFAFHWFAMSSTCYNPFIYCWLNesFRSEL 352
gi 410928466 320 ICWFPLNCYVVLLssht----iqsSNALYFCFHWLAMSSTCYNPFIYCCLNptFRQEL 373

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