Conserved Protein Domain Family
7tmA_PR4-like

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cd15392: 7tmA_PR4-like 
neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.
Statistics
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PSSM-Id: 320514
View PSSM: cd15392
Aligned: 10 rows
Threshold Bit Score: 376.701
Threshold Setting Gi: 31204165
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##              #####
gi 51704225  106 IIVYMLYIPIFIFALIGNGTVCYIVYSTPRmrtvTNYFIASLAIGDILMSFFCVPSSFISLfil--nyWPFGlalCHFVN 183
gi 2707338    98 VIIVLMYVLIILVAVGGNLLFSYVIVMYPKmrsvTNLFLLNLAISDIVKAVICNPFAFIANlil--lyWPYGefmCQVVT 175
gi 110764421 383 GIIYFVYSTVFVVALTGNGLVCYVVHSSPRmktvTNFFIVNLALGDILIALFCVPTSSISTlil--qyWPFGpelCPTVI 460
gi 189234605  31 SAVYSMYAIIFVVALIGNSFVCYIVLSSPPmrtvTNFFILNLAIGDVLITLLCVPFTSVSLlm---qyWPFGgilCPVVN 107
gi 72077792   40 ALYGVIFALVTVLGVGGNSIVCYIVLGNRRmrtvTNYSIVNLAVSDILMAVMCVNFSFYAAmy---mtWPFGefmCKAVS 116
gi 443695114   7 AIIIVMYSTISVLAVGGNLIVVYIVVAYQRmrtvTNYFIVNLACSDILMAVMCIPFTFIANllm--hyWPFGaimCPIVS 84
gi 31204165   45 VVVWLAYTAILAASLVGNCSVLAIVASQPRmrtvTNLFLANLALGDLLMTLFCVPFSSVSLfvl--qyWPFGaalCQTVN 122
gi 72077794   37 VLMIVTYATVSILGVGGNAVVCYIVLGHARmrtvTNYFIVNLALADILMAVMCVNLTLYATly---mrWPFGvvmCKITY 113
gi 405974990  38 AIIITAYSFTILLSVGGNGTVCYIVFRARRmrtvMNFFIVSLALSDIFMAVFCIPFTFVANlil--neWPFGetmCPVVT 115
gi 71999368   51 MLCILFYSILCVCCVYGNVLVILVIVYFKRlrtaTNILILNLAVADLLISVFCIPFSYWQVliyddqrWLFGsmmCSLLA 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # ##  #                                             # #####                     
gi 51704225  184 YSQAVSVLVSAYTLVAISIDRYIAIMWPlk---pRITKRYATFIIAGVWFIALATALPIPIVsgldipmsp----whtkc 256
gi 2707338   176 YIQVVAVFLSAFTLVAMSVDRYVAILKPmr---pRLSKRAFAITMATIWILSLSAPLPTAITsrvtkq----------sn 242
gi 110764421 461 YLQAVSVLVSAYTLVAISIDRYIAIMWPlk---pRLSKRQAQLLILAVWMLAMLISLPIAIVsklfqpstq-----ykrc 532
gi 189234605 108 YSQALSVFVSAYTLVAISIDKYMIIMWPlk---pRISKRFATYIIALVWLIAGITVLPSATFttlindenilgtsayeqc 184
gi 72077792  117 YIQSVSVSVSIFTLVSIGVDRYIAICHPlv---lRMGSSQALTVIAVIWVVACVVALPSLIFstvgve-----------g 182
gi 443695114  85 YLQAVVVFLSAFTLVAISLDRYRAIMFPlk---pRMTTNQVAMVIAVIWMLSLAVPLPIAIMsrieeqtdr----fnasv 157
gi 31204165  123 YFQAVSVLVSAYTLVALSADRYRAIMWPlrsrrrPPRRPIALLLIGLVWVGAAATALPIPLHsalvqpsaw-----hahc 197
gi 72077794  114 FVQSLSVSVSIFTLIAISLDRYVAIMYPlr---pRMTAKQTILIAICIWIFAGAYAMPMLIYahvasd-----------e 179
gi 405974990 116 FLQSVTVFLSSLTLVAISIDRYVAIIYPfr---aKMTKMQAFIVISVIWLFSFVISIPTAMTarthtyvn-------vst 185
gi 71999368  131 FLQAMAVFLSAWTLVVISFDRWMAIMFLltp-niRITRRRALYLVAATWIFSILMALPLLFTtrffed----------qd 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #  ### ### ##                                                
gi 51704225  257 ekyiCREMWPsr-----tqEYYYTLSLFALQFVVPLGVLIFTYARITIRVwakrppgea----etnrdqrmaRSKRKMVK 327
gi 2707338   243 stglCLEHFEnd-----hnRYIYSIVIMMLQYFVPLAVITVTNTHIGYIVwikktpgea----eedrdrrmaASKRRLVK 313
gi 110764421 533 nqyiCIEVWPsl-----enRYYYSIALLVLQYVIPITVLVFTYTSIAIMVwgkrppgea----enirdqrmaRSKRKMVK 603
gi 189234605 185 dkyiCAEEYSkvg---qeyGDLYTKVLMFLQYVIPSLVLLFTYTSIGVVIwchripgea----ensrdqriaKNKTKMIK 257
gi 72077792  183 dstfCSESHWe-------qSKIYTYILMGIQYFVPLCVLAVTYGRIGYVIwsrrtpget----qasrdkkinESKTKLVK 251
gi 443695114 158 vryiCKEKWPql-----qhRYIYSLCLMILQYFLPLFVLMFTYSSIAVVIwvkkmpgea----ennrdqrmaASKRKMVK 228
gi 31204165  198 gqavCTEVWPda-----taDRAYSLTLALAQFALPLGTLVYTYACIGWRVwarstnrtglvppssnsgrqfrRARRRTVR 272
gi 72077794  180 sasfCTDSDWr-------fTKHYSWVGLILQYILPLSVLAIVYIRLARKIwgrrtpgev----qanrdkklsESKTKLVK 248
gi 405974990 186 apefCEEILWhdp----tlEYIYGVAIMLLQYFIPLVIFVCAYGRIIVAMwvektpgea----vssrdqrmsESKKKIIR 257
gi 71999368  200 glpnCGENWTyfgdsgeqvRKVYSSMVLILQYVVPQAVLIITYTHIGIKMwnsrvpgmqng-atkkmivdrhESVKKLVP 278
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                    #  ## ##  #            ## ###  #  ##                     
gi 51704225  328 MMLTVVIVFTCCWLPFNILQLLLndeef--ahwdpLPYVWFAFHWLAMSHCCYNPIIYCYMNarFRSGF 394
gi 2707338   314 MIIIVVVIYAVCWLPVHVITLVGdhnpdi-ynqphMNVVWLCAQWLAMSHSCYNPFVYFSLSatFRRNL 381
gi 110764421 604 MMVTVVIVFTVCWLPFNILNLIMdnnetv-gswtwFPFVWMILHWLAMSHSCYNPVIYCWMNarFRTGF 671
gi 189234605 258 MMVTVVCVYTICWLPYNVLMIFKehis-----gsvMVYLYFPLHGLAMSHACYNPIIYCYMNarFRNGF 321
gi 72077792  252 MFAMVVLLFALCYLPIHFFNILQevyenv-lyyryIKLVYLTVLLAAMSNCVYSPFIYCWMNakFRNGF 319
gi 443695114 229 MMITVVIIYALCWLPLHTVTIVGdvhesv-whfrhIQVLWSGAHWLAMSNCCYNPIVYCWMNskFRQGF 296
gi 31204165  273 MTLAVVAAFVVCWLPFNALLLAPlddp----swapLPYLWFACHWLAMSHCCLNPLIYCYMNakFRAGF 337
gi 72077794  249 MFATVVLIFALCYLPIHTLNLIQdihysi-lyfpyIKLIYLAGHLISMSNCFVNPFIYCWMNrkFRNGF 316
gi 405974990 258 MMIVVVVIYATCWLPLNIINIAGdidpti-ydtkgMNYIWMSFHWLAMSNCMYNPFIYCWMNskFRNGF 325
gi 71999368  279 MVILISALFALCWLPLLILINVIpefypdinswgyILYLWWFAHGLAMSHSMVNPIIYFIRNarFREGF 347

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