Conserved Protein Domain Family
7tmA_leucokinin-like

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cd15393: 7tmA_leucokinin-like 
leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaeastagnalis.
Statistics
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PSSM-Id: 320515
View PSSM: cd15393
Aligned: 7 rows
Threshold Bit Score: 436.454
Threshold Setting Gi: 215507473
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 8118100    56 VLLSIFYGIISLVAVAGNFMVMWIVATSRRmqtvTNFFIANLAVADIIIGLFSIPFQFQAAllqrWVLPefmCAFCPFVQ 135
gi 268054205  20 VILSLLYGVISLMSVLGNALVIFVVLRNKKmrtiTNSFLVNLAISDIIQGLFATPFQFAPAilyrWPFGdfmCPFVPFIK 99
gi 215507473  55 FLLSFCYGLISLVSIVGNILVLWIVASSRRmqtvTNIFIANLAVADIIIGVFSIPFQFQAAllqrWLLPyfmCAFCPYVQ 134
gi 1857635    62 CLLAFLYGSISLLAVIGNGLVILVIVKNRRmhtvTNIFIPNLAVSDVIIGLFSIPFQFQAAllqrWVLAnfmSSLPPFVQ 141
gi 45550542   36 ALLSIFYGGISIVAVIGNTLVIWVVATTRQmrtvTNMYIANLAFADVIIGLFCIPFQFQAAllqsWNLPwfmCSFCPFVQ 115
gi 443714012  45 VLLSILYGSISILSVVGNFLVILVIIKNKSmqtvTNFFFANLSVADVMIGIFSIPFQFQAAlsqrWDLPhilCPVAPFVK 124
gi 71981145   47 IIWCMLYAIIAFMAVVGNLLVLYITLFRLRvrsiTTYFILNLGFADLFTGIFAIPFKFQAAlfqeWFLPrslCRIVPYVE 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                           # #####                          
gi 8118100   136 VLSVNVSIFTLTAIALDRYRAVMSPlk-aRTTKLRAKFIICGIWTLAVAAALPCALAlrvetqves-----halnltkpf 209
gi 268054205 100 TLSILVSIGTLTVISVDRYFAVCHPlr-rRLTPCSTAVTVGIIWINGICTSTPKLLNlktiehil-------pdggvrmf 171
gi 215507473 135 VVSVNVSVFTLTAIAIERYRAITSPlkarFCSKTTAKILILIIWISSLVVACPNAVAlrvvllmdk-----atglrekpf 209
gi 1857635   142 VVTVNLTIFTLRVIAVDRYIAVIHPfk-aGCSKKRAAIIISIIWAVGIGAALPVPLFywvedlte--------nnivipr 212
gi 45550542  116 ALSVNVSVFTLTAIAIDRHRAIINPlr-aRPTKFVSKFIIGGIWMLALLFAVPFAIAfrveelterfrennetynvtrpf 194
gi 443714012 125 ELTVNVSVITLTVISIDRYFAVLHPlk-aRVSRKVAKIVMSVVWAFSLASAIPVAIVyrvkftddk------htngkkpf 197
gi 71981145  127 TVALTVSVFTLVTSAVHEFRTMFFSkc-sQMSPRSAKRCVLLIWIMAVLVSLPHGLFhntyefpdd------nntsivqq 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  ### ### ##                                                      
gi 8118100   210 CHEVGIsr---kaWRIYNHVLVCLQYFFPLLTICFVYARMGLKLkeskspgnaqgardagilKNKKKVIKMLFVIVALFA 286
gi 268054205 172 CVPQWSsd---qcRNIYHLYIFVTSYAVPLVVITVAYSLIAKKMyvtktpgesndardqniaKNKKKVITMGIGLVIVFA 248
gi 215507473 210 CLNVGMqp---rtWKAYNHALVCVQYLLPLTIVCYTYGRIWKKLrqskipgntetvrdahivRNKNKVIKMMAIVVIIFA 286
gi 1857635   213 CDWHAPdnw-ldfHLYYNTLLVCFQYLLPLVIITYCYCRIAWHIwgsrrpgah-vttedvrgRNKRKVVKMMIIVVCLFV 290
gi 45550542  195 CMNKNLsd---dqLQSFRYTLVFVQYLVPFCVISFVYIQMAVRLwgtrapgnaqdsrditllKNKKKVIKMLIIVVIIFG 271
gi 443714012 198 CSPTFGtfndidlGRVFHLYVAVVQYFLPLVIICYSYFRIMHRIwltkapgsamdtrdqimnRNKRKVIKMLLIVVALFA 277
gi 71981145  200 CLPVYPda---gwWKTYNVYLVIIQYFVPMIILDTAYTMIAVKIwslsqsr----veldetkMATQKLMRTLIIVVACFS 272
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1          #  ## ##  #           ## ###  #  ##                     
gi 8118100   287 FCWLPYQLYNILRevfpkidkykyINIIWFCTHWLAMSNSCYNPFIYAIYNerFKREF 344
gi 268054205 249 FCWLPLQLYDFLKfvtpdilsykhINIIWFCCNWLAMSNAACNPFIYGLLNdnFKREY 306
gi 215507473 287 LCWLPYQTYNLLAeiyptintyryINVIWFCSHWLAMSNSCYNPFIYAIYSekFSAEF 344
gi 1857635   291 LCWLPLQMYNLLHninplinhyhyINIIWFSSNWLAMSNSCYNPFIYGLLNekFKREF 348
gi 45550542  272 LCWLPLQLYNILYvtipeindyhfISIVWFCCDWLAMSNSCYNPFIYGIYNekFKREF 329
gi 443714012 278 FCWLPLQTYNLLSiilekinkyryINIIWFCSNWLAMSNSCYNPFIYGLLNekFKHSF 335
gi 71981145  273 LCWFPLETYLLLNelkpeingwkyINLVFFFSHWLAMSNSCLNPIIYGLYNtkYNEEY 330

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