Conserved Protein Domain Family
7tmA_PrRP_R

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cd15394: 7tmA_PrRP_R 
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.
Statistics
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PSSM-Id: 320516
View PSSM: cd15394
Aligned: 9 rows
Threshold Bit Score: 423.382
Threshold Setting Gi: 66793457
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##            ###### 
gi 311033415  61 GLIVLLYSVVVVVGLVGNCLLVLVIARVRRLhnvTNFLIGNLALSDVLMCTACVPLTLAYAFeprgWVFGggLCHLVFFL 140
gi 169646293  35 PLFIPLYTMLVLIACSGNLLLLILIGLNKKLhstTNFLIGNLALVDLVMCLFCVPLTAFYAFdergWVFGqfMCHFVTLM 114
gi 59709485   43 PLIIPCYSLVVFVGVIGNYLLIYVICKTKKMhnvTNFLVGNLAFSDMLMCATCVPLTLAYAFeprgWVYGrfMCYFVFLM 122
gi 87299594   59 PLIIPCYALVVLVGVFGNYLLLYVICQTKKMhnvTNFFIGNLAFSDMLMCATCVPFTLAYAFnprgWVFGrfMCYLVFLI 138
gi 66793457   28 PLFIPLYATLVAVACTGNLFLILLIALTKKLhctTNFLIGNLAAADFVMCLACVPLTVSYAFevrgWLFGmfMCYFVTLM 107
gi 229293684 220 PLLIPMFGAIVLVGVVGNVLLTYVILRNKSMrsvTNVFICNLAVSDIATCVMCIPFTLAYSLdh-sWYFGevMCYLVFSL 298
gi 632970774  48 TLIIPLYSIVVVMGILGNCLLVYVIARVKKMhnvTNFLIGNLASSDVLMCTACIPLTLAYVFepggWLFGraACHLVLFL 127
gi 557023977  39 PLIIPCYTLVVFVGIFGNYLLIYVICKTKKMhnvTNFLIGNLAFSDMLMCATCVPLTLAYAFeprgWVYGrfMCYFVFLM 118
gi 301622134  35 ALIIPCYSLVVFTGIFGNYLLIYVICRTKKMhnvTNFLVGNLAFSDMLMCATCVPLTLAYVFeprgWVFGhfLCYFVFLM 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                          # #####                          
gi 311033415 141 QPVTVYVSVFTLTTIAVDRYVVLVHPLRrrislRLSAYAVLAIWALSAVLALPAAVHtyhvel--kphdvrLCEEFWGsq 218
gi 169646293 115 QTATVFAAVLSLTAIAVDRYVVVAYPIRrrggrWFCGWLVVSIWLCALAMSTPTALHtvyldlsetghemaVCEEFWHgq 194
gi 59709485  123 QPVTVFVSVFTLTVIAVDRYYATVYPFRrrltiPVCAYILAAIWLLSCTLAAPALVHtyhaef--peldfsICEEFWFhm 200
gi 87299594  139 QPVTVYVSVFTLTAIGVDRYYATVHPLKkrisvLACTYLLSGIWILSCGLVAPAVAHtyhvef--kdegftICEEFWMgq 216
gi 66793457  108 QATTVFVSVLSLTAIAIDRYIVVAYPIHrrisrKSCVCVVACIWLLSILASVPTSLHtqyldlnaighdmiICEEFWKhk 187
gi 229293684 299 QPTSVYLSIMTLTAIAIDRYYVIMYPFKprmsmRTCATIIGLIWLVAVGLSLPVGINthyldfteigldfyVCKEIWDer 378
gi 632970774 128 QPVTVYVSIFTLTAIAVDRYVAIVHPLRrrvslKLSAYLMVSVWALACCLALPATAHtyyvel--kdqgvaICEEFWErk 205
gi 557023977 119 QPLTVFVSVFTLTVIAVDRYYATAYPLRrrltiPTCAYILAAIWLLSCVLAAPALIHtyhvef--peldfsICEEFWVdm 196
gi 301622134 115 QPVTVYVSVFTLTVIAVDRYHATVYPLRrrltiPTCAYILAGIWLLSCLMAAPALAHtyhvef--pqldfsICEEFWFgm 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  ### ### ##                                                          #  ## 
gi 311033415 219 erqRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPgcvtqs--qadwdrARRRRTFCLLVVIVVVFAVCWLPLHV 296
gi 169646293 195 elsRLIYSCFFLLLSYFVPLAAVSISYCAISCHLQHRATPrlmaatpsnqekwgRKRRKTFRLLLVSVLSFAFSWLPLQI 274
gi 59709485  201 rrdRLAYAYSTLIITYVLPLAVISLSYLRISVKLKNRVVPgnvtqg--qaewdrARRRKTFRLLVLVVAAFGVCWLPLHI 278
gi 87299594  217 ekeRLAYAYSTLFITYVLPLSALCISYLCISVKLRNCVVPghrtqs--qaeaqrARKRKTFRLVSLVVAAFGICWLPISV 294
gi 66793457  188 ereRLLYSCLMLLLSYMLPLLAVSVSFCAISYHLQRRNIPgaaypg---rdkwsKTKQKTFRVLTVSVVCFAVCWLPLQV 264
gi 229293684 379 -kqQMIYTNTMWVVQYWLPLLMISAAYAKIGHKLRNRVMPgsmter--qqeeqnRRKRRTNRLMMSVVVAFAICWFPINI 455
gi 632970774 206 deeRRAYACSLLAITYILPLTIILVSYLRISVKLKNRVVPgsvtqt--qadwdkARRKRTFCLLVVVVTVFGACWLPLHA 283
gi 557023977 197 ekqRLAYAYSTLIITYVLPLTVISLSYLRISVKLKNRVVPgnitqs--qaewdrARRRKTFRLLVLVVAAFGICWLPLHI 274
gi 301622134 193 ekkRLAYAYSTLILTYALPFIIIALSYLRISVKLKNRVVPgnitnv--qaewdrARRKKTFRLLVLVVGAFGMCWLPLHI 270
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1        ##  #             ## ###  #  ##                     
gi 311033415 297 FNLLRDLDphai--dpyAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREEL 346
gi 169646293 275 VNLIRDLDtdfailsknHVNVIQVSCHLLAMSSACYNPFIYASLHKKFLSYL 326
gi 59709485  279 FNMMKDIDisli--dkqYFNFIQLLCHWFAMMSACTNAFLYAWLHDSFRGEL 328
gi 87299594  295 FNVLRDIDidli--dkrYFLLIQLLCHLCGMSSSCCNPFLYAWLHDRFRAEL 344
gi 66793457  265 VNFIRDIDeeftildkrYVNVIQVSCHLIAMSSACYNPFIYASLHDKFRFHL 316
gi 229293684 456 FNVINDVNidli--hekYYNLIQLLCLWFAMLSSCVNPFLYAWKHDSFRKHL 505
gi 632970774 284 FNIVRDIDidii--dkyYFNLVQLSCHWLAMSSACYNPFIYAWLHDSFRQEL 333
gi 557023977 275 FNMMKDIDinli--dkqCFNLIQLLCHWFAMTSACTNAFLYAWLHDSFRGEL 324
gi 301622134 271 FNIMKDIDihli--dkqYFNLVQLLCHWLAMMSACTNSLLYAWLHDSFRGEL 320

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