Conserved Protein Domain Family
7tmA_NPY1R

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cd15395: 7tmA_NPY1R 
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.
Statistics
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PSSM-Id: 320517
View PSSM: cd15395
Aligned: 6 rows
Threshold Bit Score: 515.905
Threshold Setting Gi: 156139171
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 128997     41 FTLALAYGAVIILGVSGNLALIIIILKQKEmrnvTNILIVNLSFSDLLVAIMCLPFTFVYTlmdhWVFGeamCKLNPFVQ 120
gi 156139171  47 VIMAVAYSAVVLLGVIGNLALILVIARQRElhnvTNVLIANLSVSDLLMAVVCLPFTFIYTfmdhWVFGavmCKLNSLVQ 126
gi 464292     36 FTLALAYGAVIILGLSGNLALIIIILKQKEmrnvTNILIVNLSFSDLLATIMCLPFTLIYTlmdhWIFGevmCKLNEYIQ 115
gi 71895855   41 FTLALAYGTVIILGVSGNLALIVIILKQKEmrnvTNILIVNLSFSDLLVTIMCLPFTFVYTlmdhWIFGeamCKLNPFVQ 120
gi 557013164  41 FTLAVAYSAVILLGVSGNLALIAIITKQKEmhnvTNILIANLSFSDLLMSIMCLPFTFVYTlmdhWIFGeamCKLNSMVQ 120
gi 632962535  42 FTLALAYSAVIILGVSGNLMLITIIMKQKEmhnvTNILIVNLSISDLLITLMCLPFTFVYTfmdhWVFGkamCKMNSMIQ 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                          # #####                           
gi 128997    121 CVSITVSIFSLVLIAVERHQLIINPrgwrpnnRHAYVGIAVIWVLAVASSLPFLIYqvmtdepfq---nvtldaykdKYV 197
gi 156139171 127 CCSVSVSIFSLVLIAIERHQLILHPrgwrpslNHACLGISLTWALAVLTATPFLLFsrvtdaplkqlpsvfqeqyrgKVV 206
gi 464292    116 CVSVTVSIFSLVLIAIERHQLIINPrgwrpnnRHACFGITVIWGFAMACSTPLMMYsvltdepfk---nisldsyigKYV 192
gi 71895855  121 CASITVSVFSLVLIAIERHQLIINPrgwrpnnRHAYMGIAAIWVLATASSLPFLIYhvltdepfr---nitfdeykdKYV 197
gi 557013164 121 CISITVSIFSLVLIAIERHQLIINPrgwrpnnKHAYIGIAAIWILALLTSLPFLIFqvltdepfkn-vpksfdaytgKYV 199
gi 632962535 122 CISITVSVFSLVLIAIERHQLIINPrgwrpnnKHAYVSIATMWVLALLASLPFLLFqvltdeplqn-vpnywenfagKYV 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                                       # 
gi 128997    198 CFDQFPsdshRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRnnmmdkmrdnKYRSSETKRINIMLLSIVVAFAVCWL 277
gi 156139171 207 CVEEWPsreiKLTYTTGMLVLQYITPLTFIFICYLKIYTRLQRRnnmmerirenKYRSSESKRINIMLFSIVVAFAVCWL 286
gi 464292    193 CLEDFPedkfRLSYTTLLFILQYLGPLCFIFVCYTKIFLRLKRRnnmmdkirdnKYRSSETKRINIMLLSIVVGFALCWL 272
gi 71895855  198 CLDLFPldtaRLSYTTTLLVIQYFGPLCFIFICYLKIYFRLKKRsnmmdkmrdsKYRSSETKRINIMLISIVVAFAVCWL 277
gi 557013164 200 CMNHFPsetlRLTYTTCLTVMQYIGPLCFIFICYLKIYIRLKRRndmmdkmrdnKYRSNETKRINVMLISIVVAFAVCWL 279
gi 632962535 201 CLDQWPsenqRLAYTTCLLVVQYFGPLCFIFICYLKIYIRLKRRndmmdkmrenKSRADENRRITIMLISIVVAFAICWL 280
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1         ## ##  #             ## ###  #  ##                     
gi 128997    278 PLTIFNTVFdwnhqi--iatcnHNLLFLLCHLTAMISTCVNPIFYGFLNknFQRDL 331
gi 156139171 287 PLNVFNAVIdwnhev--amnctHNLLFSLCHLTAMCSVCINPVFYGFLNrnFQRDL 340
gi 464292    273 PFFIFNLVFdwnhea--vatcnHNLLFLICHLTAMISTCVNPIFYGFLNknFQRDL 326
gi 71895855  278 PLTIFNIVFdwnheilpvatcsHNLLFLICHLTAMISTCVNPIFYGFLNknFQRDL 333
gi 557013164 280 PLNIFNAVFdwnhem--istcnHNLLFLVCHLTAMISTCVNPIFYGFLNknFQRDL 333
gi 632962535 281 PLNIFNAVFdwkhea--itnchHNLIFSICHLTAMLSTCVNPVFYGFLNknFQRDL 334

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