Conserved Protein Domain Family
7tmA_NPY4R

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cd15397: 7tmA_NPY4R 
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.
Statistics
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PSSM-Id: 320519
View PSSM: cd15397
Aligned: 9 rows
Threshold Bit Score: 437.633
Threshold Setting Gi: 190337618
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 19071213   41 VFLATSYSLETVLGIVGNICLIAVIARQKEktnvTNILISNLIISDLFMCLVCLPFTVVYTmmdyWIFGevmCKMTSFTQ 120
gi 190337618  43 LTLVLCYCLVLILGLLGNILLICIIMHQRDppnvTSILIANLSVSDILVSVFCLPFTVVYTlmdhWIFGallCRLMPFVQ 122
gi 2739141    26 TFLIVAYSTMLAVGLVGNTCLVVVITRQKEmrnvTNIFIVNLSCSDILVCLVCLPVTIIYTlmdrWILGealCKVTPFVQ 105
gi 1709423    42 VFIVTSYSIETVVGVLGNLCLMCVTVRQKEkanvTNLLIANLAFSDFLMCLLCQPLTAVYTimdyWIFGetlCKMSAFIQ 121
gi 18253297   28 SFVIATYCVLIALGLLGNSLLVLVILRHSElhnvTNILIVNLAFSDMLVGLVCLPLTIAYTlmdhWIFGealCKGSPFLQ 107
gi 33302257   38 IFLVASHCAVMAVGLLGNICLICVIAKQKEktnvTNMLIANLSFSDIMICVFCLPFTVVYTlmdyWIFGevlCKMVTFIQ 117
gi 163915257  34 TFLVVAYSALIAVGLIGNSCLVFVIARQREmrnvTNIFIANLSCSDILMALVCLPVTVIYTlmnrWILGealCKVTNFVQ 113
gi 557007650  47 FCLVILYSLVMVVGLVGNICLICVITKQKEktnvTNILIANLSFSDIMVCAFCLPFTVVYTimdyWIFGevlCKMSPFIQ 126
gi 193870727  37 FFLVVSYCTVMAMGLLGNICLIYVIARQKEkanvTNILIANLSFSDIMVCTFCLPFTVVYTlmdhWIFGevfCKMTPFIQ 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                          # #####                           
gi 19071213  121 CTSVTVSILSLVLIALERHQLIINPTGWRPsiSQAYLGIGVIWTLACLMSLPFLTTSILsndlyeqlshimnfsydkaiC 200
gi 190337618 123 CVSVTVSVLSLVLIALERHQLILHPSGWKPsvPQAYIAVLTVWLLACVTSLPFLAFHLLtsepyslfp---aplsqlqvC 199
gi 2739141   106 CMSVTVSIFSMVLIALERHQLIIHPTGWKPvvRHSYLAVAVIWIIACFISLPFLSFNILtnspfhnlslpfnpfsdhfiC 185
gi 1709423   122 CMSVTVSILSLVLVALERHQLIINPTGWKPsiSQAYLGIVLIWVIACVLSLPFLANSILenvfhknhskalefladkvvC 201
gi 18253297  108 CSAVSVSIFSLVLIAIERHQLIINPTGWKPslNHAYVAIGAIWVAAFAMSSPFLAFHVLtdepyrnlshyfpdygekvaC 187
gi 33302257  118 CMSVTVSILSLVIIALERHQLILNPTGWKPsvPQAYLTVLVIWMLACFISLPLVAFQVLtdeplrdlpvfiaplanqaiC 197
gi 163915257 114 CISVTVSVLSLVLIALERHQLIIHPTGWKPlpWHAYLAVAVTWAVSCFISLPFLSFTILtrhpfqnlslpfdpfidhfvC 193
gi 557007650 127 CTSVTVSVLSLVLIALERHQLIINPTGWKPsvLQAYLAVVVIWMLACFTSLPFLAFHVLtdepykklsvfiasladkavC 206
gi 193870727 117 CMSVTVSILSLVMIALERHQLIINPTGWKPsvSQAYLAVVIIWMLGCLVSLPFVAFHILtdelyknlfifntsladkaiC 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #  ### ### ##                                                          
gi 19071213  201 IDSWPseqhRLIYTTTLLLLQYCIPLFFIILCYLRIYLRLqkrkdmfe------kseysnraVQLRRINILLASMVAAFA 274
gi 190337618 200 LEVWPsqehKLAYTTSLLLFQYCCPLLLMLLCYLRIFLRLqrrermlerqcsrnredehrrvMHSKRINVMLATLVAAFA 279
gi 2739141   186 IEQWPsegnRLTYTTTLLLCQYCLPLALILVCYFRIFLRLsrrkdmver----arggrqkkaKGSKRVNAMLASIVAAFA 261
gi 1709423   202 TESWPlahhRTIYTTFLLLFQYCLPLGFILVCYARIYRRLqrqgrvfh------kgtyslraGHMKQVNVVLVVMVVAFA 275
gi 18253297  188 IEVVAlghlKFAFTTSLLVFQFSCPLLFVFLCYLRIFLRLrqrkkmlptg--regggngvraSHMKKINMMLVAIVAGFA 265
gi 33302257  198 TESWSsreqKLVYTTWLLAFQYCAPLAFIAVCYGRIYWRLrtrtdlldr-----agevnrrlTNSRRITLLLGFLIVGFA 272
gi 163915257 194 TDSWPsenhRLAYTTCLLLFQYCLPLLLILLCYLRIFLRLrkrrdvvera---gggdaggrkGGHRRVNVMLLSIVVAFG 270
gi 557007650 207 TESWPsrkhKLIYTTWLFLFQYCTPLIFILVCYVRIYLRLqrrndildr-----tceenrrmAHTKRINVMLGSLVAAFA 281
gi 193870727 197 AESWPsrkeKLVYTTWLLVVQYGAPLAFIAVCYIRIYMRLrkrrdmmdr-----rsednrrlTNSRRINMMLVSLVVAFG 271
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1          #  ## ##  #           ## ###  #  ##                     
gi 19071213  275 VCWLPLHVFNTIVDWNykiispchHNLIFSLCHLVAMASTCVNPVIYGFLNsNFKKEV 332
gi 190337618 280 VCWLPLNAFNVVADWHqevlpvcnHNLLFSLCHLLAMSSTCVNPIIYGFLNsNFRKDV 337
gi 2739141   262 LCWLPLNVFNTIFDWNheaipvcqHDAIFSACHLTAMASTCVNPVIYGFLNnNFQKEL 319
gi 1709423   276 VLWLPLHVFNSLEDWHheaipichGNLIFLVCHLLAMASTCVNPFIYGFLNtNFKKEI 333
gi 18253297  266 ICWLPLYTFNAVSDWNptlllhcqHDLIFSLCHLTAMLSICINPIFYGFLNnNFLKEL 323
gi 33302257  273 LCWLPLNVFNAIADWDleavmhcrHNLIFSLCHLAGMASTCVNPVIYGFLNsNFKKEV 330
gi 163915257 271 LCWLPLTVFNALFDWDheqisacyHNLIFSLCHLAAMASTCVNPVMYGFLNsNFQKEV 328
gi 557007650 282 ICWLPLNVFNAIADWNheaimychHDLIFSLCHLAAMVSTFVNPIIYGFLNnNFKKEV 339
gi 193870727 272 LCWLPLNVFNTIVDWDlevvlhnqHNLIFSLCHLAAMSSTCVNPIIYGFLNnNFKNEV 329

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