Conserved Protein Domain Family
7tmA_NPY2R

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cd15399: 7tmA_NPY2R 
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.
Statistics
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PSSM-Id: 320521
View PSSM: cd15399
Aligned: 6 rows
Threshold Bit Score: 475.464
Threshold Setting Gi: 55742256
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 1352610    51 VVLILAYCSIILLGVIGNSLVIHVVIKFKSmrtvTNFFIANLAVADLLVNTLCLPFTLTYTlmgeWKMGpvlCHLVPYAQ 130
gi 13878606   55 IILIFAYCSIILLGVIGNSLVIHVIIKFKSmrtvTNFFIANLAVADLLVNTLCLPFTLVYTllgeWKLGpvlCHLVPYAQ 134
gi 55742256   48 ISLILAYSLIILLGLVGNTLVIYMIILYRNmrtvTNYFIANLALADLMVDTVCLPFTLVYTlldeWKFGavmCHMVPYSQ 127
gi 193870725  56 ITLILAYCSIIFLGVMGNSLVIYVVIRYKNmatvTNFFIANLAVADLMVNTLCLPFTLVYTllgeWKFGsvlCHLLPYAQ 135
gi 512816048  74 VVLILAYSSIILLGVLGNSLVIYVVIKFKTmrtvTNFFIVNLAVSDLMVNTLCLPFTLVYTllddWKFGtvlCHLVTYSQ 153
gi 557014200  52 IILIFAYCSIILLGVVGNSLVIYVVIKFKTlrtvTNFFIGNLALADLLVNTLCLPFTLIYTlldeWKFGavlCHLVPHAQ 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                          # #####                           
gi 1352610   131 GLAVQVSTITLTVIALDRHRCIVYHleskiskRISFLIIGLAWGISALLASPLAIFREYslieii-pdfeivACTEKWPg 209
gi 13878606  135 ALAVHVSTVTLTVIALDRHRCIVYHleskiskRISFLIIGVAWAVSALLASPLAIFREYslieii-pdfkivVCSEKWPg 213
gi 55742256  128 ALSVHVSILTLTIIALERYRCIVFHlgqrlnrCTSFIIIGLTWAFAAILAGPLAIFREYryeeipyidlriaVCSEKWPn 207
gi 193870725 136 ALSVHVSTVTLTVIALDRHRCIVYHleskiskKRCFIIISITWLASAVLACPQAIFREYiniele--glkmqACSEKWPn 213
gi 512816048 154 GLAVQVSTVTLMVIALDRHRCIVYHleskistKICFMIIGITWVCSALLASPLAIFKEYsvivis-sdfqiqACSERWPv 232
gi 557014200 132 GLAVNVSTVTLTVIALDRHRCIVYHleskiskKISVLIIGLTWSASALIASPLAIFREYsvvefs-gyfkiqACSEKWPn 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  ### ### ##                                                    #  ## ## 
gi 1352610   210 eeksiyGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHvspgaandhyhQRRQKTTKMLVCVVVVFAVSWLPLHAFQL 289
gi 13878606  214 egqlnyGTIYSVSMLLIQYVLPLAIISYAYTRIWTKLKNHvspgagndhyhHRRQKTTKMLVCVVVVFAVSWLPFHAFQL 293
gi 55742256  208 gt-nrdAVIYSLSMLLLQYVVPLAIISYAYVCIWIKLKNHvspsn-rndgiVRRKKTTKMLALVVVVFAVCWLPFHMFQL 285
gi 193870725 214 gn-dndGTLYSVSMLLLQYVLPLVIICFAYIRIWTKLKNHvspgggndhhhQRRRKTTKMLVMVVVVFAVSWLPFHVFQL 292
gi 512816048 233 gd-lnyGTIYSISMLLIQYIVPLAIISYAYIRIWTKLKNHvspgggndhyhQRRRKTTKMLVAVVVVFAVCWLPFHAFQL 311
gi 557014200 211 gh-vndGIIYSVSMLLIQYILPLSIISYAYITIWIKLRNHvspgg-gndhyHRRRKTTKMLVTVVAVFAVSWLPFHVFQL 288
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
Feature 1         #           ## ###  #  ##                     
gi 1352610   290 AVDIDsqvldlkEYKLIFTVFHIIAMCSTFANPLLYGWMNsNYRKAF 336
gi 13878606  294 VSDIDsqvldlkEYKLIYTVFHVIAMCSTFANPLLYGWMNnNYRTAF 340
gi 55742256  286 ASDLDlil-kfkEYKLIYTLFHIVAMCSTFVNPLLYGWMNqNYRNGF 331
gi 193870725 293 AIDIDknifdlkEYKLLYTIFHVIAMCSTFVNPLVYGWMNkNYRYSF 339
gi 512816048 312 ASDIDgkvldlnEYKLIYTIFHVIAMCSTFANPLLYGWMNnNYRTAF 358
gi 557014200 289 ASDIDskvldlnEYKLIYTIFHVIAMCSTFANPLLYGWMNnNYRTAF 335

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