Conserved Protein Domain Family
7tmA_Mel1C

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cd15401: 7tmA_Mel1C 
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors
Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.
Statistics
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PSSM-Id: 320523
View PSSM: cd15401
Aligned: 3 rows
Threshold Bit Score: 515.23
Threshold Setting Gi: 1346550
Created: 11-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 1346550    25 SGLAAVLIVTIVVDVLGNALVILSVLRNKKLRNaGNIFVVSLSVADLVVAVYPYPLILSAIfhngWTMGnihCQISGFLM 104
gi 1346551    33 SALAVVLIFTIVVDVLGNILVILSVLRNKKLQNaGNLFVVSLSIADLVVAVYPYPVILIAIfqngWTLGnihCQISGFLM 112
gi 556964257  32 IVLAGLLIFTIVVDILGNLLVILSIFRNKKLRNpGNIFVVSLAVADLFVAVYPFPLDLLAIlhdgWILGdihCQISGFLT 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                     #  #
gi 1346550   105 GLSVIGSIFNITAIAINRYCYICHslrYDKLFnlKNTCCYICLTWTLTVVAIVPNFFVGslqYDPRIYSCTFaqtvSTSY 184
gi 1346551   113 GLSVIGSVFNITAIAINRYCYICHslrYDKLYnqRSTWCYLGLTWILTIIAIVPNFFVGslqYDPRIFSCTFaqtvSSSY 192
gi 556964257 112 GLSVIGSVFNITAIAINRYFFICHslkYDRLYnmKKTCCYVCLTWVLTLAAILPNFYAGslkYDPRVYSCTFaqtvSSSY 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ## ### ##                                                      #  ## ##  #      
gi 1346550   185 TITVVVVHFIVPLSIVTFCYLRIWILVIqvkhrvrqdckqkirAADIRNFLTMFVVFVLFAVCWGPLNFIGLAVSINPsk 264
gi 1346551   193 TITVVVVHFIVPLSVVTFCYLRIWVLVIqvkhrvrqdfkqkltQTDLRNFLTMFVVFVLFAVCWAPLNFIGLAVAINPfh 272
gi 556964257 192 TIIVVVVHFMLPLTIVAFCYLQIWVLVIqvkhrvrkdsqqklkANQIRNFLTMFVVFVLFAVCWGPLNFIGLAVATNPlk 271
                        250       260       270
                 ....*....|....*....|....*....|....*....
Feature 1             ## ###  #  ##                     
gi 1346550   265 vqphIPEWLFVLSYFMAYFNSCLNAVIYGLLNqNFRKEY 303
gi 1346551   273 vapkIPEWLFVLSYFMAYFNSCLNAVIYGVLNqNFRKEY 311
gi 556964257 272 mapkIPEWLFVTSYFMAYFNSCLNALVYGVLNqNFRNEY 310

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