Conserved Protein Domain Family
7tmA_GPR45

?
cd15403: 7tmA_GPR45 
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
?
PSSM-Id: 320525
View PSSM: cd15403
Aligned: 6 rows
Threshold Bit Score: 507.849
Threshold Setting Gi: 26398277
Created: 13-Jan-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 82654940   35 ISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMrsaINLLLATLAFSDIMLSLCCMPFTAVTLItvrWHFGdhFCRLSATLY 114
gi 26398277   35 MLLAIIMILMIAIAFLGNAIVCLIVYQKPAMrsaINLLLATLAFSDIMLSLFCMPFTAVTIItgsWLFGtqFCQISAMLY 114
gi 47226910   42 VTLAALMIFMITIGFLGNAIVCLIVYQKPAMrsaINLLLATLAFSDIMLSLLCMPFTAVTVAsadWSFGseFCRASIMLY 121
gi 327268003  35 ILLAIIMLLMIAVGFLGNAIVCLIVYQKPAMrsaINLLLATLAFSDIMLSLFCMPFTAVTIItvnWNFGahFCRISGMLY 114
gi 556984244  38 ILLAIVMMCMIAIGFLGNAIVCLIVYQKPAMrsaINLLLATLAFSDIMLSLLCMPFTAVTIIttnWHFGayFCRVSAMLY 117
gi 632939842  36 ILVTIVMMSMVAIGFLGNTIVCLIVYQKPAMrsaINLLLATLAFSDIMLSLMCMPFTTATIItvdWIFGnyFCRISAMLY 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                         # #####                            
gi 82654940  115 WFFVLEGVAILLIISVDRFLIIVqRQDKLnpRRAKVIIAVSWVLSFCIAGPSLTGWtlve---vparAPQCVLGYTelpA 191
gi 26398277  115 WFFVLEGVAILLIISVDRFLIIVqRQDKLnpHRAKIMIAASWVLSFCISLPSVVGWtlve---vptrAPQCVLGYTefsA 191
gi 47226910  122 WLFVLEGVSILLIISVDRFLIIVqRQDKLtpHRAKLLIAGSWVLSLCVALPSVVGWrkssakiggawAPQCVLGYSdsvA 201
gi 327268003 115 WFFVLEGVAILLIISVDRFLIIVqHQDKLnpHRAKVMIAISWAFSFCVSFPSVVGWtfve---vpsrAPQCVLGYTelpA 191
gi 556984244 118 WFFVLEGVAILLIISVDRFLIIVqRQDKLnlHRAKIMIAISWGISFCISFPSVVCWtive---vparAPQCVLGYTefpA 194
gi 632939842 116 WFFVLEGVAILLIISVDRYLIIVqRQDKLnpHRAKMMIVISWVFSFCISFPSVVGWtvve---vptrAPQCVLGYTesmA 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  ### ### ##                                                                   
gi 82654940  192 DRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRknavrvhnqsdsldlrq----ltraglrrlqrqqqvsvDLSFKTKAFT 267
gi 26398277  192 DRVYAVMLIVAVFFIPFSVMLYSYLCILNTVRrnavrihthadslclsq----vsklglmglqrphqmnvDMSFKTRAFT 267
gi 47226910  202 DRGYTVLLAVAVFFVPFAIMLYSYMCILNTVRrntlrihnhtsersclpglnqvskmrltglqrppqvkvDMSFKTRAFT 281
gi 327268003 192 DRAYAVMLLVTIFFVPFSIMLYSYLCILNTVRrntvrihnhtenvclsq----vsklglvvlpkahqmnvDMSFKTRAFT 267
gi 556984244 195 DRVYVVLLVVSVFFIPFSIMLYSYLCILNTVRrnavrihnhadslclsq----vsklglmglqrphqmnvDMSFKTRAFT 270
gi 632939842 193 NRVYAVLLLVTIFFVPFGVMLYSYLCILNTVRrnavriqnhadslclsq----vsklglmglqrphqlnvDMSFKTRAFT 268
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                    #  ## ##  #           ## ###  #  ##                     
gi 82654940  268 TILILFVGFSLCWLPHSVYSLLSVFsqrfycgssFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREAC 335
gi 26398277  268 TILILFIGFSLCWLPHSVFSLLSVFsrtfyysssFYSISTCTLWLTYLKSVFNPVIYCWRIKKFREAC 335
gi 47226910  282 TILILFVGFSVCWLPHTVVSLLAVFsrrfyyssvFYPLSTGALWLSYLKTVFNPVIYCWRIRKFREAC 349
gi 327268003 268 TILILFVGFSLCWLPHTVFSLMSVFsrqfyygpsFYITSTCVLWLSYLKSVFNPVIYCWRIKKFREAC 335
gi 556984244 271 TILILFIGFSVCWLPHTVFSLLSVFsrrfyyspsFYTISSCVLWLTYLKSVFNPVIYCWRIKKFREAC 338
gi 632939842 269 TILILFIGFSFCWLPYTVYSLLSVFsrkfyysqsFYVISTYILWLSYLKSVFNPIIYCWRIRKFRESC 336

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap