Conserved Protein Domain Family
7tmA_OR8B-like

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cd15405: 7tmA_OR8B-like 
olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320527
View PSSM: cd15405
Aligned: 12 rows
Threshold Bit Score: 407.958
Threshold Setting Gi: 431904418
Created: 17-Jan-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 14423794   25 IPLFFLFLGFYVVTVVGNLGLITLIRLNSHLhtPMYFFLYNLSFIDFCYSSVITPKMLMSFvlkkNSISYagCMTQLFFF 104
gi 85692675   28 LPLFVLFLMNYTATVMGNLTLMNLICLNSNLhtPMYFFLFNLSFIDFCYSMVFTPKMLMSFilekNTISFggCMAQLFFF 107
gi 47577795   25 IPLFLLFLVIYMISTMGNLALIILIFLNSHLhtPMYFFLLNLSCIDLCYCSVGTPKMLMNFvlkeNAISYegCMTQFYFF 104
gi 47577729   25 FPFFFLFLGIYVITVAGNLGLLTLIGMNSPLhtPMYYFLFNLSFIDLCYSTVITPKLLVNFvsekNTISYegCMTQLYFY 104
gi 47577727   25 MPLFFLFLGIYVVTIVANLGLITLISLNSHLhtPMYYFLFNLSFVDICYSSVFTPKMLINFvvekNTISYtgCLTQLYFF 104
gi 47577747   25 ILLFFVFLAMYLVTVLGNLFLIILTVLNSHLhtPMYFFLFNLAFVDLCYSSVFTPQMLMNLitrkNTISYmeCMTQLYFF 104
gi 311033419  25 QPLFFLFLVVYIVTMVGNLGLIILFGLNSHLhtPMYYFLFNLSFIDLCYSSVFTPKMLMNFvskkNIISYvgCMTQLFFF 104
gi 47577817   25 LPLFFLFLVNYITTVVGNLSLMSLICWNSNLqtPMYFFLFNLSFIDLCYSFVFTPKTLMSFvlekNVISFtgCMTQLFFI 104
gi 47577797   28 WPLFVLFLVNYTATVMGNLTLMTLICLNSHLhtPMYFFILNLSFIDFCYSFVFTPKMLMGFvsehNTISFtgCMTQLFFF 107
gi 47576205   29 LPLFFLFLGIYVVSMVGNLGLIVLIVLNPHLhtPMYYFLFNLSFTDLCYSSVITPKMLVGFvk-qNIISHaeCMTQLFFF 107
gi 20532194   25 LPLFLLFLGIYVFTVVGNLGLITLIGINPSLhtPMYFFLFNLSFIDLCYSCVFTPKMLNDFvs-eSIISYvgCMTQLFFF 103
gi 431904418  26 IPLFFLFLDFYMVIVVGNLGLITLTEQNSHLhtLKYFFFYNLSFIDFHCSTVFTPKVLMSFvskkNIISYa-GCVIQLFF 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 14423794  105 LFFVVSESFILSAMAYDRYVAICNPllYMVTMsPQVCFLLLLGVYGMGFAGAMAHTAcmmgVTFCANnLVNHY-MCDILP 183
gi 85692675  108 LFFVNSESYVLTAMAYDRYVAICKPltYKVIMsPKICCLLIFSSYLMGFASAMAHTGcmirLSFCDSnIINHY-MCDIFP 186
gi 47577795  105 CFFIISECYVLTAMAYDRYVAICNPllYNIVMsPKVCSYLMIASYLVGFSDGMIHTGcvlrLTFCDGnTINHY-FCDLLP 183
gi 47577729  105 CFFVSAECYVLTVMAYDRYVAICKPllYTVTMsPQVCSLLTLTVYVGAFIGAWAHTGcmlrLTFCKDnTVNHY-MCDILP 183
gi 47577727  105 CFFVITECYILTAMAYDRYVAICKPllYNVILsPRICALFMFGAYVMGFWGSLAHTLcmarLTFCDAnLVNHY-LCDILP 183
gi 47577747  105 CFFVISECYVLTSMAYDRYVAICNPllYNLVMsSKLCLKLMLGSYFIAFSESVAHTIcimrLTFCKAnTINHY-FCDIPP 183
gi 311033419 105 LFFVISECYMLTSMAYDRYVAICNPllYKVTMsHQVCSMLTFAAYIMGLAGATAHTGcmlrLTFCSAnIINHY-LCDILP 183
gi 47577817  105 CLFVNSECYLLTAMAYDRYVAICQPllYMVIMsPVTCSLMMFGSYVMGFVAAIVHTGfmirLSFCDSnIINHY-MCDIFP 183
gi 47577797  108 CLFVNSECYVLTAMAYDRYVAICRPllYTVVMsPRACCLLMLAAHLMGVSSAIVHTGciihLRFCGSkVINHY-MCDTFP 186
gi 47576205  108 AFFVIDECCILTAMAYDRYAAICKPllYKVIMsHQVCFMLMVGGYTVGFVGAIAHTVsmlrLTFCDGnIINHY-MCDIPP 186
gi 20532194  104 CFFVNSECYVLVSMAYDRYVAICNPllYMVTMsPRVCFLLMFGSYVVGFAGAMAHTGsmlrLTFCDSnVIDHY-LCDVLP 182
gi 431904418 105 LFFVVSESFTLSAMAYDHYGTICDPlvYTATVsPQVCLFLFLVVYGMGFPGAMAHMVcmirLTFCVNnLIDHSvCDILLS 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                            #  ## ##  # 
gi 14423794  184 LLECACTSTyvNELVVFVVVGIDIGVPTVTIFISYALILSSIfhidstEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPf 263
gi 85692675  187 LLPLSCSSTyvNELMSSVVVGSAIILCCLIILISYAMILFNIihmssgKGWSKALGTCGSHIITVSLFYGSGLLAYVKPs 266
gi 47577795  184 LLQLSCTSTyvNEIEVLIISGINIIVPTLIVFTSYGFILSSIlkinstAGRSKAFSTCSSHIIAVSLFFGSGAYMYLKPs 263
gi 47577729  184 LLELSCSSTyiNELVVFIVVGFDVGVPSITIIVSYTFILSSIlhihstEGRSKAFSTCSSHIIVVSVFFGSGAFMYLHPs 263
gi 47577727  184 VLQLSCTSTynNEVVVFVLVGMNIVVSSSTTFVSYGFIIANIlrisstQGRAKAFNTCSSHIMTISLFCGSAIFMYMQPs 263
gi 47577747  184 LLQLSCTTTyiNKLVIFVASSINIIVPISTIFISYGFILSNIfhisssEGRSKAFSTCSSHIIAAFLFFGSGAFMYFKPs 263
gi 311033419 184 LLQLSCTSTyvNEVVVLIVVGINIMVPSCTILISYVFIVTSIlhikstQGRSKAFSTCSSHVIALSLFFGSAAFMYIKYs 263
gi 47577817  184 LLQLSCSSTyaNELVCSVFVSTVVLASSFLILTSYALILFNIiqlssgKGLCKAMSTCSSHIMTVVLFYGFGMLTHIKTs 263
gi 47577797  187 LLELSCGSNhaSELVSSVSVAVVVVMSSLIIVSSYSLILINVihlsssKGWSKAVSTCSSHIITVALFYGFGLLAHIKPs 266
gi 47576205  187 LLKLSCTSTsiNELVVFIVVGVSIIVPSVTVSVSYTLILSNIlrihstKGRSKALSTCSSHMIAVSLFFGSSSFIYFKSs 266
gi 20532194  183 LLQLSCTSThvSELVFFIVVGVITMLSSISIVISYALILSNIlcipsaEGRSKAFSTWGSHIIAVALFFGSGTFTYLTTs 262
gi 431904418 185 LLMRSCTITh-VNEMVAFVVSIDTGVPTVTIFISYALISSNSlsihstEGSFKDFSTYGSHIIAVSLLFGSRAFMYLKPs 263
                        250       260       270
                 ....*....|....*....|....*....|....*...
Feature 1            ## ###  #  ##                     
gi 14423794  264 sllAMNQGKVSSLFYTTVVPMLNPLIYSLRNkDVKVAL 301
gi 85692675  267 sakTVGQGKFFSVFYTLLVPMLNPLIYSLRNkDVKLAV 304
gi 47577795  264 ssgSLDQGKISSVFYNIVVPMMNPLIYSLRNkDVKTAL 301
gi 47577729  264 svlSMDQGKVSTVFYTIVVPMLNPLIYSFRNkEVKVAL 301
gi 47577727  264 dveSMDKGKVASVFYTNVAPMLNPLIYSLRNkDVKLAL 301
gi 47577747  264 sggSMNEGKISSVFYTNVIPMINPLLYSLRNkDIKVAL 301
gi 311033419 264 s-gSMEQGKVSSVFYTNVVPMLNPLIYSLRNkDVKVAL 300
gi 47577817  264 sdeSVNQGKFFCLLCTFLMPLLNPFIYSLRNkDVKLAL 301
gi 47577797  267 sseSVVQRKFFSVVYTFVLPLLNPLIYSLRNkDVKLAV 304
gi 47576205  267 pvgSVDQDKISTVFYTVVVPMMNPFIYSLRNkDVQIAL 304
gi 20532194  263 fpgSMNHGRFASVFYTNVVPMLNPSIYSLRNkDDKLAL 300
gi 431904418 264 sllPVNQRKVSSLFYITVVPVRNLVIYSLRNkDINIAL 301

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