Conserved Protein Domain Family
7tmA_OR5P-like

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cd15416: 7tmA_OR5P-like 
olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320538
Aligned: 13 rows
Threshold Bit Score: 438.339
Created: 17-Jan-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q8WZ94        25 AILFLVFLGIYVVTLMGNISIIVLIRRSHHLHTPMYIFLCHLAFVDIGYSSSVTPVMLMSFLRKETSLPvagCVAQLCSV 104 human
Q8VFD3        28 IVLFTIILCIYLVTVSGNLSTILLIRVSSQLHHPMYFFLSHLASADIGYSSSVTPNMLVNFLVKQNTISyigCSIQFGSA 107 house mouse
Q8VGI5        25 AILFVFFLPVYIVTVVGNISIILLIRSSPQLHTPMYLFLSHLAFVDIGYSTSVTPIMLISFLREETTIPlagCAAQLGSD 104 house mouse
Q8WZ92        21 TDDPILRVILFMIILSGNLSIIILIRISSQLHHPMYFFLSHLAFADMAYSSSVTPNMLVNFLVERNTVSylgCAIQLGSA 100 human
XP_003773674  28 IILFVFFLGIYVFTVMGNFCTIILIRLSPQLHTPMYLFLSHLAFVDFWYSTGATPNMLANFLEEKNIITysgCVTQLCSL 107 Tasmanian devil
XP_001514411  25 IPLFMLFLLIYAVTLLGNLLIVLIIRVSSQLHTPMYFFLSHLSFSDSCYSSSVTPKMLANFLADKKTISypgCVAQLCAA 104 platypus
XP_001514520  25 VIFFVLFLIIYIITVLGNLVIILLIRVHSQLHTPMYFFLCHLSFSDTCYSSSVTLNMLVSFLSVKKSISylgCAAQFCAI 104 platypus
XP_007664758  25 LIFFLIFLLVYSVTIMGNLCIIMLIRVSSQLHTPMYLFLSHLAFIDIWYSTSVTPEMLKGFLVGRDTISyagCAAQLCSA 104 platypus
XP_007664792  24 TVLFVVFLMIYSFTLLGNLAITLVIKINSHLHTPMYLLLSHLSLSDIGFSSSVTPKMLVNLLAERKTISfpaCAAQLFIG 103 platypus
XP_001514491  60 AILFGLFLVTYMITLMGNTGIIMLIRASPQLHTPMYYFLSHLSLSDMCYSSSVTPKMLENLLQGKRTISfggCALQFAVA 139 platypus
XP_001514391  25 VIFFLLFLVMYSVTLLGNLVIIILIRISSQLHTPMYFFLSHLSFSDTCFSSSVTPKMLVNFLAEKKTISypaCATQFWLA 104 platypus
XP_007664791  25 VILFGLFLVTYTVTLLGNCSIILLIRIHSHLHTPMYFLLSHLSFTDMCISSTATPKLLENSLMGKTSISymeCAVQFFIA 104 platypus
XP_006267791  25 ITLCFAFIMMYAFILGGNLATITLISSSPWLHTPMYFFLSHLAFADICISSSVAPKMLVGLFVGRTNISyigCAAQLTSI 104 American alligator
Feature 1        #  #                                            # #####                         
Q8WZ94       105 VTFGTAECFLLAAMAYDRYVAICSPLLYSTCMSPGVCIILVGMSYLGGCVNAWTFIGCLLRLSFCGPNKVNHFFCDYSPL 184 human
Q8VFD3       108 AFFGGLECFLLAVMAYDRFVAICNPLLYSTKMSTQVCVQLVVGSYIGGFLNASFATVSFLFLFFCGPNIINHFFCDFAPL 187 house mouse
Q8VGI5       105 VAFGTTECFLLATMAYDRYVAICSPLLYSTQMSPAICCFLLGASYLGGCMNASSFTGCFVNLNFCGPNKVNHFFCDLFPL 184 house mouse
Q8WZ92       101 AFFATVECVLLAAMAYDRFVAICSPLLYSTKMSTQVSVQLLLVVYIAGFLIAVSYTTSFYFLLFCGPNQVNHFFCDFAPL 180 human
XP_003773674 108 VTFGATESFLLTSMAYDRYMAICNPLLYSVKMSDQVCLLLIVISYIGGCLNGVTYTGCLLNLSFCGPNVIDHFFCDFSPL 187 Tasmanian devil
XP_001514411 105 ATFGVVEYCLLAAMAYDRYVAICKPLLYVVCMPQRLCALLVIASYLTSCLNTVVYTANVFSLTFCGSLEINHFYCDVPPL 184 platypus
XP_001514520 105 FTFGTNECLLLAVMAYDRFTAIRHPLLYTAMMTKKICTLLVASSYTGAGINALVETTSVFSLSFCGPNVMNHFLCDFHPL 184 platypus
XP_007664758 105 FAFGTSEGILLAMMAYDRYVAICNPLFYAISMSNRVCVQLITVSYVGGCLNALVFTTFVFNLVFCGPDEIDHFFCDFPPL 184 platypus
XP_007664792 104 ALFGGTECFLLAAMAYDRYAAICKPLIYLALMSEKKCLGLVALSYLASVINALMCTNWVFSLWFCGPNEINHFFCDSPAL 183 platypus
XP_001514491 140 ATFGTNECFLLAVMAFDRYSAICRPLLYPLIMSNKVRVQLVMASYVGSCVNAAIFESSVFSLSFCGPNEINHFYCDFPPL 219 platypus
XP_001514391 105 ATFGFSECFLLAVMAYDRYVAICSPLIYTLIMSEKTCASLVAASYVASFMNSLLCTYGVFSLFFCGPDQINHFYCDTPAL 184 platypus
XP_007664791 105 SIFGPAECLLLAAMAYDRYVAICKPLAYPAIMSKRFCLLMVVDSYLGSLLTAFVFTSNLFRLSFCGPNVINHFFCDFPPL 184 platypus
XP_006267791 105 VTFGIVECLLLAAMAYDRYVAICNPLLYKVIMSQNLCMWLVAVSYIGGCMNSMAFLTCVLSLSFQGTVELDHFFCDLPAL 184 American alligator
Feature 1                  #  ### ### ##                                            #  ## ##  #  
Q8WZ94       185 LKLACSHdfTFEIIPAISSGSIIVATVCVIAISYIYILITILKMHSTKGRHKAFSTCTSHLTAVTLFYGTITFIYVMPKS 264 human
Q8VFD3       188 IELSCSDvrISVLVTSFSAGTVTMLTVLVIAISYTYILITILKMRSTEGRHKAFSTCTSHLTAVSLFYGTITFIYVMPKS 267 house mouse
Q8VGI5       185 VKLSCGHayIAEISPSISSASVLVSTLSTIIVSYIYILHSILRMRSAEGRNKAFSTCTSHLTAVTLFYGTVLFVYVMPKS 264 house mouse
Q8WZ92       181 LELSCSDisVSTVVLSFSSGSIIVVTVCVIAVCYIYILITILKMRSTEGHHKAFSTCTSHLTVVTLFYGTITFIYVMPNF 260 human
XP_003773674 188 VKLSCYHafIAEILPAIYSAIIIAIALVTIIISYLYIFFTILSMSSTEGRHKAFSTCTSHLTAVTLFYGTIIFIYVMPTS 267 Tasmanian devil
XP_001514411 185 LKLSCTEprLAQILPAASMAIIMLVTVLTTLISYVYILLAILKIQSSGGRQKAFFTCASHLMTVTLFYGTTMFIYLLPSS 264 platypus
XP_001514520 185 LQLSCSDisLAKVLNSFVSGIIVAITIPTVLISYLYILLAILKIPSTQGRRKAFSTCGAHLTAVALFYGTTTFVYVLPNS 264 platypus
XP_007664758 185 MEISCSDihLIQTLSSISAAIIILSTVPTIIISYVYILCAIMRIQASDGRQKAFSTCASHLTAVILYYGTITFTYVQPSS 264 platypus
XP_007664792 184 LKLSCSDthLAKIFPSISSGTVVTITIVIIVISYLYIVTAILRIHTTEGRHKAFLTCASHLMTVTLYYGTVTFIYVRHSS 263 platypus
XP_001514491 220 LELACSDprVAQILNSITSVLISLVTILIIAISYLCILSAILRIPSTEGRHKAFSTCASHLTAVTLFYGTATFIYTQPNS 299 platypus
XP_001514391 185 LKLSCSDiqLAKIFQSSSAGITVIITSGTIITSYVYILISILRMPTKGGRRKAFSTCASHLLVVTLFYGTVTFIYVMPNS 264 platypus
XP_007664791 185 LKLSCSDttLAKIIPSSFATLLILSTLAIIVVSYLYIMLAILRIKSSAGRGKAFSTCASHLTAVSLFYGSSAFIYMLPKS 264 platypus
XP_006267791 185 LKLSSTNitITCTRPSVLSGSILSVTLLIITFSYFCILSAILRIRCAHGRNKAFSTCASHLTAVTLFCGTVSFTYLQPDS 264 American alligator
Feature 1           ## ###  #  ##                       
Q8WZ94       265 SYSTDQNKVVSVFYTVVIPMLNPLIYSLRNKEIKGALKR 303 human
Q8VFD3       268 RYSTDQNKVVSVFYMVVIPMLNPLIYSLRNNEIKGALRR 306 house mouse
Q8VGI5       265 SYSADQVKVASVVYTVVIPMLNPLIYSLRNKEVKEAMKK 303 house mouse
Q8WZ92       261 SYSTDQNKVVSVLYTVVIPMLNPLIYSLRNKEIKGALKR 299 human
XP_003773674 268 SYSTDQNKVVSVFYIVVIPMLNPMIYSLRNKEIKDALKR 306 Tasmanian devil
XP_001514411 265 SFSMDQKKMVSVCYMILIPMLNPMIYSLRNKEVKDAVLK 303 platypus
XP_001514520 265 RDTLEQNKVFSVFYIIVIPMLNPFIYSLRNREVKGTLRR 303 platypus
XP_007664758 265 SRSLEQNKIVSLFYTVVIPMLNPLIYTLRNKDVKRALMK 303 platypus
XP_007664792 264 NYSMDQNKVVSVFYLVVIPMLNPLIYSLRNKKIMGTLRR 302 platypus
XP_001514491 300 RYSMDQKKVVSVFYMVVIPMLNPLIYSLRNKDVKEALRR 338 platypus
XP_001514391 265 DNSVDLNKMVSVFYMVMIPMLNPVIYCLRNKDVIEALKR 303 platypus
XP_007664791 265 KYSMDQKKVVSMFYMVVIPMLNPLIYTLRNKEVKEALKR 303 platypus
XP_006267791 265 NISMDQAKIVSVFYVLVIPMLNPLIYSLRNKEVKDAVER 303 American alligator

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