Conserved Protein Domain Family
7tmA_OR2T-like

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cd15421: 7tmA_OR2T-like 
olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320543
Aligned: 56 rows
Threshold Bit Score: 384.98
Created: 12-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
O43869        75 GLIFAIISIIFFTALMANGVMIFLIQTDLRlhtPMYFLLSHLSLIDMMYISTIVPKMLVNYlldqRTISFvgCTAQHFLY 154 human
Q8NG83        25 TFLFFLVLAIFSVAFMGNSVMVLLIYLDTQlhtPMYLLLSQLSLMDLMLICTTVPKMAFNYlsgsKSISMagCATQIFFY 104 human
Q96R30        26 LVLFSVVMAVFTVALCGNVLLIFLIYMDPHlhtPMYFFLSQLSLMDLMLVCTNVPKMAANFlsgrKSISFvgCGIQIGLF 105 human
Q8NG77        23 QVLFMMLLATVLTSLFSNALMILLIHWDHRlhrPMYFLLSQLSLMDMMLVSTTVPKMAADYltgnKAISRagCGVQIFFL 102 human
NP_667088     26 LFLFSIIMVMFLVALSGNGLMILLILMDSRlhtPMYFFLSWLSLMDLMLISTIVPRMAADFllgrGSISFagCGLQILFF 105 house mouse
XP_001511658  25 QVLFALVMMTSITSLMGNTAIILLIHRDLHlhtPMYFLLGQLSIMDVMLVFTTIPQMAGDFwygrNSISLvgCAIQIFIF 104 platypus
NP_666388     27 SFFFSLVLLAFGAAVVGNILLLMVIQVDRRlhtPMYFFLSQLSIMDLTMTCTVVPKMATNFlsggKLISLggCASQIFFV 106 house mouse
Q96R27        25 TFLFSLVLGIFSLALMENISMVLLIYIEKQlhtPMYFLLSQLSLMDLMLICTTLPKMIFSYlsgkKSISLagCGTQIFFY 104 human
NP_001000771  25 LFLLSAVLVIFTTSLMGNTLMILLICRDPRlhtPMYFLLSQLSFMDMMLVSTIVPKMAANYlmntRSISPagCGSQIFLF 104 Norway rat
XP_003935415  34 QVLFAVLLTIVVTSLLGDALLIVLTHRDRRlhtPVCFLLSQLSLVDVVLLFTTVPTMAAGYlaghQAVPLaxCGGQIFFL 113 Bolivian squirr...
Feature 1        #  #                                            # #####                         
O43869       155 LTLVGAEFFLLGLMAYDRYVAICNPlrYPVLMsRRVCWMIIAGSWFGGSLDGFLLTPitmsFPFCNSREINHFf---CEA 231 human
Q8NG83       105 TSLLGSECFLLAVMAYDRYTAICHPlrYTNLMsPKICGLMTAFSWILGSTDGIIDVVatfsFSYCGSREIAHFf---CDF 181 human
Q96R30       106 VCLVGSEGLLLGLMAYDRYVAISHPlhYPILMnQRVCLQITGSSWAFGIIDGLIQMVvvmnFPYCGLRKVNHFf---CEM 182 human
Q8NG77       103 PTLGGGECFLLAAMAYDRYAAVCHPlrYPTLMsWQLCLRMTMSSWLLGAADGLLQAVatlsFPYCGAHEIDHFf---CEA 179 human
NP_667088    106 LTLLGDECFLLAFMAYDRYVAISNPlrYSVIMsRRVCWLMVAGSWLFGLVDGLIQAVftlrFPYCGSQEIDHFf---CEV 182 house mouse
XP_001511658 105 LTLEGGECFLLAAMAYDRFVAICCPlrYPVLMsPRLCLLLAVVSWLLGATDGLVQAGitmsYRFCRSREVNHFf---CEA 181 platypus
NP_666388    107 VTVGGAECFLLAVMAYDRYMAVCYPlrYPVLMnWKACSFLATASWMGGMADSVIDVGvvfsFPYCGSLEVDHFf---CEV 183 house mouse
Q96R27       105 VSLLGAECFLLAVMAYDRYVAICHPlqYTILMnPKLCVFMTVASWTLGSLDGIIVLAavlsFSYCSSLEIHHFf---CDV 181 human
NP_001000771 105 LTLAGGECFLLAAMSYDRYVAICYPlrYHVLMsPKLCAYLTVGSWLLGAADGLMQAGtilsFPFCQSRTINHFf---CEA 181 Norway rat
XP_003935415 114 LTLGGGERFLLAAVACDRCVTVCHPlrYPVLTsWQLCLRMAVPRWLPGAADGLLQAAaalsFPHRRAHQIDRIdhffCEA 193 Bolivian squirr...
Feature 1                     #  ### ### ##                                            #  ## ##  
O43869       232 PAVLKLACADtalYETVMYVCCVLMLLIPFSVVLASYARILTTVqcmssvEGRKKAFATCSSHMTVVSLFYGAAMYTYML 311 human
Q8NG83       182 PSLLILSCSDtsiFEKILFICCIVMIVFPVAIIIASYARVILAVihmgsgEGRRKAFTTCSSHLLVVGMYYGAALFMYIR 261 human
Q96R30       183 LSLLKLACVDtslFEKVIFACCVFMLLFPFSIIVASYAHILGTVlqmhsaQAWKKALATCSSHLTAVTLFYGAAMFIYLR 262 human
Q8NG77       180 PVLVRLACADtsvFENAMYICCVLMLLVPFSLILSSYGLILAAVllmrstEARKKAFATCSSHVAVVGLFYGAGIFTYMR 259 human
NP_667088    183 PAVLKLACADtslYETMIYVCCVLMLLLPFSVISASYLRILVAVlrmrsaEGRRKAFATCSSHMIVVSLFYGAAMITYMR 262 house mouse
XP_001511658 182 PALVRLACDDtmvFESVMYVCCVLMLLIPFSVILGSYGLILETIlrmksvEAKKKAFTTCSSHLSVVGLFYGAAIYIYIR 261 platypus
NP_666388    184 PALLRLSCADtslFEDLIYACCVVMLLLPLGVIVASYARVLTTVmrmpstEGKQKALTTCSSHLAVVGLYYGGAIFSYMQ 263 house mouse
Q96R27       182 AALLPLSCTEtsaFERLLVICCVVMLIFPVSVIILSYSHVLRAVihmgsgESRRKAFTTCSSHLSVVGLYYGAAMFMYMR 261 human
NP_001000771 182 PSLVRLACADtrvFEFFMYICCILMLLIPLSLVLASYSLILVAVlrmrssAARKKAFATCSSHLAVVGLFYGAIIFIYMR 261 Norway rat
XP_003935415 194 PVLLRLACADssaFENAMYIRCVLTLRVPFXLALSSHGLVLAAAlrtrpaEARRKPXATCSSHLAVLGLFYGAAIFTYMR 273 Bolivian squirr...
Feature 1        #     ## ###  #  ##                     
O43869       312 PhsyHKPAQDKVLSVFYTILTPMLNPLIYSLRNkDVTGAL 351 human
Q8NG83       262 PtsdRSPTQDKMVSVFYTILTPMLNPLIYSLRNkEVTRAF 301 human
Q96R30       263 PrhyRAPSHDKVASIFYTVLTPMLNPLIYSLRNrEVMGAL 302 human
Q8NG77       260 PkshRSTNHDKVVSAFYTMFTPLLNPLIYSVRNsEVKEAL 299 human
NP_667088    263 PqayHSSKQDKVVSAFYTMITPMLNPLIYSLRNkEVTGAL 302 house mouse
XP_001511658 262 PssyDSTDYDKVVSAFYTILTPVLNPLIYSLKNrEVLGAL 301 platypus
NP_666388    264 RasaRTPLGDRATSIFYTIVTPMFNPLIYSLRNrEVTSAL 303 house mouse
Q96R27       262 PaskHTPDQDKMVSAFYTILTPMLNPLIYSLRNkEVFRAL 301 human
NP_001000771 262 PrshQPGKSDKVVSAFYTIFTPVLNPLIYSVRNkEVKGAL 301 Norway rat
XP_003935415 274 PkshRSTHHDKVVSAFYTVFTPSLNPLIYGARNsEVKEAW 313 Bolivian squirrel monkey

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