Conserved Protein Domain Family
7tmA_OR2T-like

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cd15421: 7tmA_OR2T-like 
olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320543
View PSSM: cd15421
Aligned: 56 rows
Threshold Bit Score: 384.98
Threshold Setting Gi: 602676433
Created: 12-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 229462940  75 GLIFAIISIIFFTALMANGVMIFLIQTDLRlhtPMYFLLSHLSLIDMMYISTIVPKMLVNYlldqRTISFvgCTAQHFLY 154
gi 38258176   25 TFLFFLVLAIFSVAFMGNSVMVLLIYLDTQlhtPMYLLLSQLSLMDLMLICTTVPKMAFNYlsgsKSISMagCATQIFFY 104
gi 55977873   26 LVLFSVVMAVFTVALCGNVLLIFLIYMDPHlhtPMYFFLSQLSLMDLMLVCTNVPKMAANFlsgrKSISFvgCGIQIGLF 105
gi 71153027   23 QVLFMMLLATVLTSLFSNALMILLIHWDHRlhrPMYFLLSQLSLMDMMLVSTTVPKMAADYltgnKAISRagCGVQIFFL 102
gi 22129125   26 LFLFSIIMVMFLVALSGNGLMILLILMDSRlhtPMYFFLSWLSLMDLMLISTIVPRMAADFllgrGSISFagCGLQILFF 105
gi 345315372  25 QVLFALVMMTSITSLMGNTAIILLIHRDLHlhtPMYFLLGQLSIMDVMLVFTTIPQMAGDFwygrNSISLvgCAIQIFIF 104
gi 22129735   27 SFFFSLVLLAFGAAVVGNILLLMVIQVDRRlhtPMYFFLSQLSIMDLTMTCTVVPKMATNFlsggKLISLggCASQIFFV 106
gi 55977872   25 TFLFSLVLGIFSLALMENISMVLLIYIEKQlhtPMYFLLSQLSLMDLMLICTTLPKMIFSYlsgkKSISLagCGTQIFFY 104
gi 47575993   25 LFLLSAVLVIFTTSLMGNTLMILLICRDPRlhtPMYFLLSQLSFMDMMLVSTIVPKMAANYlmntRSISPagCGSQIFLF 104
gi 403288449  34 QVLFAVLLTIVVTSLLGDALLIVLTHRDRRlhtPVCFLLSQLSLVDVVLLFTTVPTMAAGYlaghQAVPLaxCGGQIFFL 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 229462940 155 LTLVGAEFFLLGLMAYDRYVAICNPlrYPVLMsRRVCWMIIAGSWFGGSLDGFLLTPitmsFPFCNSREINHFf---CEA 231
gi 38258176  105 TSLLGSECFLLAVMAYDRYTAICHPlrYTNLMsPKICGLMTAFSWILGSTDGIIDVVatfsFSYCGSREIAHFf---CDF 181
gi 55977873  106 VCLVGSEGLLLGLMAYDRYVAISHPlhYPILMnQRVCLQITGSSWAFGIIDGLIQMVvvmnFPYCGLRKVNHFf---CEM 182
gi 71153027  103 PTLGGGECFLLAAMAYDRYAAVCHPlrYPTLMsWQLCLRMTMSSWLLGAADGLLQAVatlsFPYCGAHEIDHFf---CEA 179
gi 22129125  106 LTLLGDECFLLAFMAYDRYVAISNPlrYSVIMsRRVCWLMVAGSWLFGLVDGLIQAVftlrFPYCGSQEIDHFf---CEV 182
gi 345315372 105 LTLEGGECFLLAAMAYDRFVAICCPlrYPVLMsPRLCLLLAVVSWLLGATDGLVQAGitmsYRFCRSREVNHFf---CEA 181
gi 22129735  107 VTVGGAECFLLAVMAYDRYMAVCYPlrYPVLMnWKACSFLATASWMGGMADSVIDVGvvfsFPYCGSLEVDHFf---CEV 183
gi 55977872  105 VSLLGAECFLLAVMAYDRYVAICHPlqYTILMnPKLCVFMTVASWTLGSLDGIIVLAavlsFSYCSSLEIHHFf---CDV 181
gi 47575993  105 LTLAGGECFLLAAMSYDRYVAICYPlrYHVLMsPKLCAYLTVGSWLLGAADGLMQAGtilsFPFCQSRTINHFf---CEA 181
gi 403288449 114 LTLGGGERFLLAAVACDRCVTVCHPlrYPVLTsWQLCLRMAVPRWLPGAADGLLQAAaalsFPHRRAHQIDRIdhffCEA 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  ### ### ##                                            #  ## ##  
gi 229462940 232 PAVLKLACADtalYETVMYVCCVLMLLIPFSVVLASYARILTTVqcmssvEGRKKAFATCSSHMTVVSLFYGAAMYTYML 311
gi 38258176  182 PSLLILSCSDtsiFEKILFICCIVMIVFPVAIIIASYARVILAVihmgsgEGRRKAFTTCSSHLLVVGMYYGAALFMYIR 261
gi 55977873  183 LSLLKLACVDtslFEKVIFACCVFMLLFPFSIIVASYAHILGTVlqmhsaQAWKKALATCSSHLTAVTLFYGAAMFIYLR 262
gi 71153027  180 PVLVRLACADtsvFENAMYICCVLMLLVPFSLILSSYGLILAAVllmrstEARKKAFATCSSHVAVVGLFYGAGIFTYMR 259
gi 22129125  183 PAVLKLACADtslYETMIYVCCVLMLLLPFSVISASYLRILVAVlrmrsaEGRRKAFATCSSHMIVVSLFYGAAMITYMR 262
gi 345315372 182 PALVRLACDDtmvFESVMYVCCVLMLLIPFSVILGSYGLILETIlrmksvEAKKKAFTTCSSHLSVVGLFYGAAIYIYIR 261
gi 22129735  184 PALLRLSCADtslFEDLIYACCVVMLLLPLGVIVASYARVLTTVmrmpstEGKQKALTTCSSHLAVVGLYYGGAIFSYMQ 263
gi 55977872  182 AALLPLSCTEtsaFERLLVICCVVMLIFPVSVIILSYSHVLRAVihmgsgESRRKAFTTCSSHLSVVGLYYGAAMFMYMR 261
gi 47575993  182 PSLVRLACADtrvFEFFMYICCILMLLIPLSLVLASYSLILVAVlrmrssAARKKAFATCSSHLAVVGLFYGAIIFIYMR 261
gi 403288449 194 PVLLRLACADssaFENAMYIRCVLTLRVPFXLALSSHGLVLAAAlrtrpaEARRKPXATCSSHLAVLGLFYGAAIFTYMR 273
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
Feature 1        #     ## ###  #  ##                     
gi 229462940 312 PhsyHKPAQDKVLSVFYTILTPMLNPLIYSLRNkDVTGAL 351
gi 38258176  262 PtsdRSPTQDKMVSVFYTILTPMLNPLIYSLRNkEVTRAF 301
gi 55977873  263 PrhyRAPSHDKVASIFYTVLTPMLNPLIYSLRNrEVMGAL 302
gi 71153027  260 PkshRSTNHDKVVSAFYTMFTPLLNPLIYSVRNsEVKEAL 299
gi 22129125  263 PqayHSSKQDKVVSAFYTMITPMLNPLIYSLRNkEVTGAL 302
gi 345315372 262 PssyDSTDYDKVVSAFYTILTPVLNPLIYSLKNrEVLGAL 301
gi 22129735  264 RasaRTPLGDRATSIFYTIVTPMFNPLIYSLRNrEVTSAL 303
gi 55977872  262 PaskHTPDQDKMVSAFYTILTPMLNPLIYSLRNkEVFRAL 301
gi 47575993  262 PrshQPGKSDKVVSAFYTIFTPVLNPLIYSVRNkEVKGAL 301
gi 403288449 274 PkshRSTHHDKVVSAFYTVFTPSLNPLIYGARNsEVKEAW 313

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