Conserved Protein Domain Family
7tmA_OR2D-like

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cd15428: 7tmA_OR2D-like 
olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320545
View PSSM: cd15428
Aligned: 4 rows
Threshold Bit Score: 408.021
Threshold Setting Gi: 565308452
Created: 12-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 223590116  41 ILLFILFLIIYLLTVLGNQLIIILIFLDSRlhtPMYFFLRNLSFADLCFSTSIVPQVLVHFlvkRKTISFygCMTQIIVF 120
gi 209572777  25 QLLFIVLLGVYLVTVLGNLLLISLVHVDSQlhtPMYFFLCNLSLADLCFSTNIVPQALVHLlsrKKVIAFtlCAARLLFF 104
gi 395508252  25 MYLFLLFFIVYLMILMGNLLIVLLILMDTClhtPMYFFLANLSILELSYTTCVIPQMLGHFlaeRKSISFfrCAAQFYTF 104
gi 565308452 141 IALFVTFVFIYLMAMIGNLLLVLLVIVDSHlhsPMYFFLSNFSVLEACYTSTVVPQMLSHLlseERIIPLirCGIQLYFF 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 223590116 121 LLVGCTECALLAVMSYDRYVAVCKPlyYSTIMtQRVCLWLSFRSWASGALVSLVDTSFtfhLPYWGQNIINHYFCEPPAL 200
gi 209572777 105 LIFGCTQCALLAVMSYDRYVAICNPlrYPNIMtWKVCVQLATGSWTSGILVSVVDTTFilrLPYRGSNSIAHFFCEAPAL 184
gi 395508252 105 LFFGIAECYILSVMAYDRYVAIRDPlrYSVIMnWGFCGGLAAGCWVGGFIASTVDTMAtfqLSFCRENVINHFLCEMPAL 184
gi 565308452 221 LSFGITECFLLSVMSYDRYIAICLPlhYSLTItKKVCISMATVSWVGGLFFSAINTAFtlnLSFGNHNKIDHFLCEMPAL 300
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 223590116 201 LKLASidtYSTEMAIFSMGVVILLAPVSLILGSYWNIISTVIQmqsgEGRLKAFSTCGSHLIVVVLFYGSGIFTYMRPNs 280
gi 209572777 185 LILAStdtHASEMAIFLMGVVILLIPVFLILVSYGRIIVTVVKmkstVGSLKAFSTCGSHLMVVILFYGSAIITYMTPKs 264
gi 395508252 185 LHLSCtdtSHVEMVMNVLCIFTLVCPVTFITFSYAHIINVVLHiqsaQGRRKAFSTCSSHLIVVMVLYGTVLSLYIRPRs 264
gi 565308452 301 VKIASgdtHQAKMCMSISCLFTLVLPLLLILASYTRILYSIFGkgslTGKHKAISTCSSHMMVVSLFFGSVLSIYMQPKs 380
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1           ## ###  #  ##                     
gi 223590116 281 ktTKELDKMISVFYTAVTPMLNPIIYSLRNKDVKGAL 317
gi 209572777 265 --SKQQEKSVSVFYAIVTPMLNPLIYSLRNKDVKAAL 299
gi 395508252 265 lsSPKYDKIISVFYVAFTPIFNPLIYSLRNKEVKMAL 301
gi 565308452 381 stSKEYVKMASVFYIIITPALNPLIYSLRNKEVTHAL 417

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