Conserved Protein Domain Family
7tmA_OR2F-like

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cd15429: 7tmA_OR2F-like 
olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320546
View PSSM: cd15429
Aligned: 10 rows
Threshold Bit Score: 458.404
Threshold Setting Gi: 47576889
Created: 12-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 14423778   25 ISLFSLFLVTYLMTVLGNCLIVLLIRLDSRlhtpMYFFLTNLSLVDVSYATSVVPQLLAHFlaehKAIPFqsCAAQLFFS 104
gi 47576889   25 VSLFVLFLAMYLLTVLGNLLIIILIKLDSKlhtpMYFFLSILSFVDICYTNSTVPQMLVHFlsarKSIPFhsCVLQLYIS 104
gi 47576917   24 AGLFVLFGVTYLLTLLGNGLIVLLIALDPRlhlpMYFFLCHLSVVDICYTSSGVPQMLAHFpmekKTISFalCGTQHFFA 103
gi 564243599  25 EDMFVLFLTMYLVTLAGNLAIVTVIIIDSHlhtpMYYFLSHLAFLDICYTTTIIPQMLASFlvehKTISFagCVLQMFIS 104
gi 602669896  25 RGLFALFLITYLVTLTGNILIILIIKRDPQlhtpMYYFLSHLSFLDMCYTTTIIPQMLYNLladcKTISFggCVVQMFIS 104
gi 557322552  45 LWLFALFLGMYVITLVGNTVIIVTIRIDPRldtpMYFFLGNLSFLDICYTSSVVPQMLVHFlaqhKAISFssCTAQLYVS 124
gi 557322560  55 HWLFVLFLAMYIITLAGNALIITVIWLDPRldtpMYFFLGNLSFLNICYTTSVVPQMLIHFlaqhKVISFsrCTAQLFVS 134
gi 564247119  25 LGLFVLFLGIYVITVVGNTLIITAIHLDPRfntpMYFFLENLSFLDICYSTTGAPQILAHFlvqhKTISFnrCMAQLFIS 104
gi 334348686  25 LYLFVLFLVMYLVTMLGNFLIIHLIRLDTRlhtpMYFFLSVLSIVDICYMNSTVPQMLIHFlssrKSIPFcsCVFQFYIS 104
gi 345316911  25 ASLFVLFLVTYMLTLMGNFLILVLIWLDSRlhspMYFFLGHLSLIDICYASSVIPQLLAHLlvvkKAIPYlrCAAQLYFS 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 14423778  105 LALGGIEFVLLAVMAYDRHVAVSDRlrYSAIMhGGLCARLAITSWVSGSINSLVQTAitfQLPMCTNkFIDHIsCELLAV 184
gi 47576889  105 LAMGSTEFFLLGAMAYDRYVAVCHPlhYMVIMhGGLCLRLASACLTAGLSNSLMQTLmifQLPFCRT-VINHFaCEMLAV 183
gi 47576917  104 LALGGTEFLLLAAMAYDRYVAVCDPlrYTVVMsPRLCMGLAGVSWFVGLVNSAVETAvtmRLPTCGHnVLNHVaCETLAL 183
gi 564243599 105 LFLGGVEFILLAVMAYDRYVAICHPlrYANIMsNHLCAWMAAGSWLSGSLNAVVQTAftlQLPFCGInAINHFgCEILTV 184
gi 602669896 105 LSLGGTEFILLAVMAYDRYMAICHPlrYNIVMrQQLCVQMALGCWLCGFLNALVQTVftlQLPFCEIkTINHFgCEVLAV 184
gi 557322552 125 LSLGSIEFILLAVMAYDRYVAICNPlhYTVTMsKRVCIQLAVASWASGFLNSLVQTTftmRLPFRGFnIINHFaCEAVAL 204
gi 557322560 135 LSLGGIEFILLATMAYDRYVAICNPlhYTAIMsKRVCIQLAASSWAVGFLSSLVQTAftmHLRFCGLpALNHFvCELLAV 214
gi 564247119 105 LTLGGTEFLLLAAMAYDRYVAICNPlqYMVIMrRSICILLAAASWTVGILNALVHTIftaRLRYCGHpLINHVsCELLAL 184
gi 334348686 105 LGLAGTEFFLLGAMAYDRYVAVCYPlhYTVIMhGGLCIALAAACWTAGFLNSLMETIitfRLPLCKN-TINHFvCETLAV 183
gi 345316911 105 LALGGIEFLLLAVMAFDRYAAVCRPlrYPAIVtRGLCAWLAAACWGGGSLNSLLQTAitfRLPVGHDdRIDHIsCELLAV 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 14423778  185 VRLACVDtssNEAAIMVSSIVLLMTPFCLVLLSYIRIISTIlkiqsrEGRKKAFHTCASHLTVVALCYGTTIFTYIQPhs 264
gi 47576889  184 LRLSCVDislNKVMVAISGFLVIMLPCILVLFSYAHIVAAIlrirssQGRRKAFGTCASHLTVVSMCFGTAIFTYMRPvg 263
gi 47576917  184 VRLACVDitlNQVVILASSVVVLLVPCCLVSLSYAHIVAAImkirstQGRHKAFETCASHLTVVSMSYGMALFTYMQPss 263
gi 564243599 185 QQLTCPNssvNDVTMLVAGVLILLIPFFLVMVSYIHILSAIlqirtaEGRRKAFSTCTAHLTVVTLCYGTAIFAYLRPrs 264
gi 602669896 185 QQLACSNtfiRDTVMLGAGVLILLTPFFLVLLSYMSILSTIlhihsaEGRHKAFSTCAAHLTVVILCFGTAIFTYLRPss 264
gi 557322552 205 IKIACSNtyvNEIILVMASVLILIIPCSFIILSYIYIISSIlrirssEGRYKTFSTCISHITVVMLCYGTAIFAYMRPra 284
gi 557322560 215 VKVACSDtyiNEAVIVVAGVVVLLVPCFMVLVSYIYIISSIlrihssRGRYKAFSTCASHLTVVTLCYGTAIFAYMRLkg 294
gi 564247119 185 IKVACFDthtNEIAILILNFVVLLVPCFLVLVSYIYIISSIlqihssQGRHKAFSTCASHLTVVIMAYGTAIFAYSKPkg 264
gi 334348686 184 VRLACVDisfNKIMVTFSVFVVLMLPCSLVLFSYAQIVKAIlrirsaQGRRKAFGTCASHLTVVSLCFGATIFTYMWPra 263
gi 345316911 185 VRLAGVDtsaNEAAIVASSVVLLMTPCVLVLLSYIRIAVAVvkirspEGRQKAFNTCAAHLTVVALCYGMAIFLYSKPrs 264
                        250       260       270
                 ....*....|....*....|....*....|....*....
Feature 1             ## ###  #  ##                     
gi 14423778  265 --gpSVLQEKLISVFYAIVMPLLNPVIYSLRNkEVKGAW 301
gi 47576889  264 --rsSAGQEKMVALFYAVVTPMLNPLIYSLRNnDVIGAL 300
gi 47576917  264 --taSAEQDKVVVIFYALVTPMLNPLIYSLRNkDVKAAF 300
gi 564243599 265 --yySPQQGKMISLFYCVVTPMLNPLIYSLRNqEVKGAL 301
gi 602669896 265 h-nsSKLGGKTVSLFYCVVTPMLNPMIYSLRNkEVTGAL 302
gi 557322552 285 --svSPNQDKMFSLFYAVVTPMLNPVIYSLRNkEVKEAL 321
gi 557322560 295 g-hlSANLDKMISLFYAIITPMLNPIIYSLRNqEVKGAL 332
gi 564247119 265 g-ksSHNLNKMIALFYGFITPMLNPIIYSLRNkDVKDFL 302
gi 334348686 264 --tsTVELEKMISIFYTVVAPMLNPLIYSLRNkEVMNAM 300
gi 345316911 265 ghgpSALREKLISLFYALLTPVLNPVIYSLRNeEMKAAG 303

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