Conserved Protein Domain Family
7tmA_OR13H-like

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cd15431: 7tmA_OR13H-like 
olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320548
View PSSM: cd15431
Aligned: 31 rows
Threshold Bit Score: 351.912
Threshold Setting Gi: 512874944
Created: 12-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372645   25 DTFFTLVLIIYLSTLLGNGFMIFLIHFDPNlhtpIYFFLSNLSFLDLCYGTASMPQALVHCfsthPYLSYprCLAQTSVS 104
gi 557328749  25 MMLIAFFLMVYLITLIGNSLIILLTLCDLHlhtpMYFFLSNLSFLDICYSSSTVPQALINFsvdrPTISYarCFSQMLST 104
gi 602665316  25 LGLMVFMVIVYSVTVVGNGLIILVITMDYHlhkpMYFFLSNLSFLDISYSTSSVPQVIANLlvdkPTMTFsmCYLQMSSG 104
gi 512879483  25 TFLFVLFFLMYILTLFGNGILIYIIARSSNihtpMYYFLCNLAFLYTVFSSSTVPKMLVDLllaeGRISYtgCMIQMCVG 104
gi 345327602  28 IIFFCILLHLYLGTIVGNMLIILVVWKEPRlhtpMYFFLCNLSFVDLCSTTTAVPLTLVNClrdcPIITYndCFAQMTIS 107
gi 602665318  27 MILIPIYIVSYLIALAGNGLIVLVVIRDPWlhnpMYFFLCNLSFIDLGLTTTTIPQSIANClverPVMSFvrCFTQMYAI 106
gi 512874944  25 TLLFCLFLTLCVSSLVANGLLIVAVKRDGHlhssMYFFLANLSIMDICYTSVIVPKALVNFlggkKSISYngCVLQIFFY 104
gi 557331405  29 ELIFVVFSLVYAVAVLGNLTIITLASLDTQlhtpMYFFLSNLAFLNICYVSLVVPKMLTNIltgsKSIPYelCAVQVYVT 108
gi 562876662  25 VPLFLLFSLTYLVNLFGNTAVIILVVMESSlqtpMYFFLCHLAFLNIFYTTAVVPKMLFNLlasrKVISYtlCLAQTYIS 104
gi 47576043   25 VPLFLIFSLVYLANCLGNTAVVTLVALDVSlqtpMYFFLCHLAFLNGFFSTVVAPKMLFNFlasrKVISYpfCLAQTYLT 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 38372645  105 LALATAECLLLAAMAYDRVVAISNPlrYSVVMnGPVCVCLVATSWGTSLVLTAMLILsl-rLHFCGANVINHFaCEILSL 183
gi 557328749 105 LFLGSTECLLLAVMAYDRYIAITNPlhYTLIMsKTRCIHLAVGSWSITFLLTIVPFFcm-pSQLCGKNEIDHFmCEILAL 183
gi 602665316 105 VWLGITEGFVLAVMAYDRYIAISAPlhYMIIMsKKLCIQLAVGTWVAGLVLGVIPIYvm-pAHFCGDNVIDHFaCELKAI 183
gi 512879483 105 LFLGQTECLLLAVMACDRFVAICNQlrYAVIMsWERCKRITAGTWLLSFLSSILPVLsk-pMLFCGENQLNHYaCEILAL 183
gi 345327602 108 IFWGITECCLLAVMAYDRFVAISYPlrYPLIMtMRACFYIAATMWISNFLLALIPVItipvRFCAGNNVVNHFvCEVEAV 187
gi 602665318 107 LLFGTTECFFLAVMAYDRLIAISRPlhYTFIMnRRVCIFLAAVTWVAAFMLGIVPCLgk-pLRFCGNNEIDHIgCEVKSI 185
gi 512874944 105 LFMGESECILLAFMAYDRYVAICSPlsYSTILsTAVCARMISASWVAGCLISALDVGfiyrLTFCGTNTIDHFfCEVPSL 184
gi 557331405 109 VFLGSAECLILMVMAFDRYVAICNPlrYNTIMnRRVCIKLAVASWTISFLVTAIPLSll-wPVLCGPNTINHFfCETPSL 187
gi 562876662 105 LFMGAAECILLAIMALDRYVAVCHPlrYLLIMnRSVCAQLAAGAWTISFFASVVPLCvt-mAPLCGPYVVDHIfCEVPVL 183
gi 47576043  105 LFLESTECFLLAVMAIDRYVAICYPlrYLLIMsWVVCTALSVAIWVIGFCASVIPLCft-iLPLCGPYVVDYLfCELPIL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 38372645  184 IKLTCsdtslNEFMILITSIFTLLLPFGFVLLSYIRIAMAIirirslQGRLKAFTTCGSHLTVVTIFYGSAISMYMKTqs 263
gi 557328749 184 MKLVCsdtskNQIFMFASGTFNLLAPFSFILFSYMRIIMTIlrihstEGKSKAFSTCGSHLTVVTIFYGTAIFMYLKPqs 263
gi 602665316 184 FKLICsdtslNQVTMFTTGVLTFLGPFAFILFSYLQIVAAIlrvhsaGGRLKAFSTCVSHLMVVTIFYSTAIFSYLRPqt 263
gi 512879483 184 VKLACgdmsyYENIIAIQSSFTILVPFSFIVVSYICILTSIlhipsvEGRTKAFSTCAAHLTVVSMFYGPSMIMYLGPss 263
gi 345327602 188 LKLVCsdttvNEILMLINSIFIFPLPFLFILLSYIRIVVAIlkipstAGRRKAFSTCGSHLTVVTIYYGTLISIYLKPqn 267
gi 602665318 186 MKLICtdtssNQITMHSTSIFGLLLPFGFIVFSYMRILQAIlripseGGRMKAFSTCGSHLSVVTMFYGVAIFTYLLPps 265
gi 512874944 185 IQLTCtnvtiNVILMFAGGAILLLLPLLLILFSYIQIFIAAkr--isCGRYKAFSTCAAHLIVVVLFYGTATFMYMRPrh 262
gi 557331405 188 VTLSCedtsqIETMMFTGSIFTLMVPLFLVLVSYIRIIQAIlkigsaAGRQKAFSTCSSHMTVVTIFYGTGMFMYMQPqa 267
gi 562876662 184 LRMVCsdtslQEVMMVVGAAGTLLLPFLLIALSYLHILVAVarmrsaEGRRKAFSTCSSHLTVVTVYYGTGMFMYMRPka 263
gi 47576043  184 LHLFCtdtslLEAMMAIGGAGTVLFPFLLIVLSYLRILVAViridsaEGRKKAFSTCASHLAVVTIYYGTGLIRYLRPks 263
                        250       260       270
                 ....*....|....*....|....*....|
Feature 1           ## ###  #  ##              
gi 38372645  264 ksYPDQDKFISVFYGALTPMLNPLIYSLRK 293
gi 557328749 264 ksSQQEDKIISVFYAVVTPMLNPLIYTLRN 293
gi 602665316 264 ksVQEMDKIVSLFYGVLTPMLNPLIYTLRN 293
gi 512879483 264 nfSSNQEKYLAVFYSILTPVLNPLIYSLRN 293
gi 345327602 268 kdSKDQDKIISIFYGIVIPMMNPLIYTLRN 297
gi 602665318 266 kkMHEAEKILFIFSSMLTPVFNPLVYTLRN 295
gi 512874944 263 -sAQQTDKIVSVFYTVVTPMLNPLIYRLRN 291
gi 557331405 268 qhSPDKDKVVSVFYAVINPMLNPIIYSLRN 297
gi 562876662 264 lsSAEGDKVISLFYAVINPALNPLIYSLRN 293
gi 47576043  264 lySAEGDKLISVFYAVIGPALNPFIYSLRN 293

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