Conserved Protein Domain Family
7tmA_OR2B2-like

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cd15432: 7tmA_OR2B2-like 
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320549
View PSSM: cd15432
Aligned: 5 rows
Threshold Bit Score: 467.726
Threshold Setting Gi: 47576665
Created: 12-Dec-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 14423800   25 IPPFVMFLFSYILTIFGNLTIILVSHVDFKlhtpMYFFLSNLSLLDLCYTTSTVPQMLVNIcntrKVISYggCVAQLFIF 104
gi 47576665   25 TPLFVIFLVAYIFALFGNISIILVSRLDPQldspMYFFVSNLSLLDLCYTTSTVPQMLVNLrgpeKTISYggCVAQLYIF 104
gi 564248493 113 KLLFVVFLITYIVTLLGNLAIIVVSRLDPSlhtpMYFFLSNLSLLDICYTTSTVPQMLVNFxstlKTISWagCVAQLFIF 192
gi 620958424  24 LVLFVVVLIFYILTLVGNAIIILVSRLDPQlrtpMYFFLTNLSFLDICFTSSSVPQLLFNLrgpdKSISYlgCAIQLFMF 103
gi 440900875  53 MVVFVAISIFYIMTLLGNSAIIILSRLDPRlhtpMYFFLANLSFLDLCYTTSTVPQMLVNIqshqRNISYggCIAQLFIF 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 14423800  105 LALGSTECLLLAVMCFDRFVAICRPLhYSIIMhQRLCFQLAAASWISGFSNSVLQSTwtlkMPLCGHKEVDHFFCEVPAL 184
gi 47576665  105 LALGSTECILLAIMAFDRFAAICKPLhYPIIMsQRRCIHMATGTWISGFANSLVQSTltvvAPRCGKRVIDHFFCEVPAL 184
gi 564248493 193 LGLGSIECVLLAVMAYDRYAAVCQPLrYTSIMnHRLCWLMASASWLSGITNSLVQTSlllrVPLCGRNRVDHFFCEVPAL 272
gi 620958424 104 LGLGGTECILLGVMAYDRFTAICKPLrYKVAMhPHLCLQLVVGAWASGIANSLLQSTwtlkMPRCGRRRVNHFFCEVPAL 183
gi 440900875 133 LGLGSTECVLLSVMAFDRYVAICQPLhYSVIMhSRLCQQLAAVAWVTGFSNSLVQTVltflLPRCGQYQVENFFCEVPAM 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 14423800  185 LKLSCVDttaNEAELFFISVLFLLIPVTLILISYAFIVQAVlriqsaEGQRKAFGTCGSHLIVVSLFYGTAISMYLQPps 264
gi 47576665  185 LKLACTDttvNEAELNVLGALLLLVPLSLILGTYVFIAQAVlklrsaESRWKAFNTCASHLLVVFLFYFTAISMYVQPps 264
gi 564248493 273 LELACADtstNEIGLLVGSVVLLPVPLGLILVSYGYIGTAVmkirsaEGRRKAFNTCTSHLMVVSLFYGTATYMYMQPps 352
gi 620958424 184 LKLSCVNtvaNEAELFFISILFLLIPMTLILISYCFIVRSVlriplvKGRRRAFETCGSHLLVVLLFYGTAIYVYLKPps 263
gi 440900875 213 LQLSCVDtwiNEVEMYAAVVVIKVIPVGLILFSYINIVRSVvriqssEGRKKAFNTCGSHLLVVVMFYGSAISGYAYMap 292
                        250       260       270
                 ....*....|....*....|....*....|....*....
Feature 1             ## ###  #  ##                     
gi 14423800  265 --psSKDRGKMVSLFCGIIAPMLNPLIYTLRNkEVKEAF 301
gi 47576665  265 --sySHDRGKIMALFYGIVTPTLNPFIYTLRNkDVKAAL 301
gi 564248493 353 --nkPHNQSKMVALCYGLITPMLNPLIYTLRNkDVHGAL 389
gi 620958424 264 --piSMEHGKMVSLFYGIITPMLNPIIYTLRNkDVHRAF 300
gi 440900875 293 knnsAKLKGKLLALFYGLVTPMLNPLIYTLRNkDVKEAV 331

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