Conserved Protein Domain Family
7tmA_OR2Y-like

?
cd15433: 7tmA_OR2Y-like 
olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
?
PSSM-Id: 320550
View PSSM: cd15433
Aligned: 4 rows
Threshold Bit Score: 431.138
Threshold Setting Gi: 47576669
Created: 12-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372774   25 PILFVFIFIFYSLTLFGNTIIIALSWLDLRlhtpMYFFLSHLSLLDLCFTTSTVPQLLINLcgvdRTITRggCVAQLFIY 104
gi 395533739  23 ELLFVVILIFYLLTLVGNTVIIVLSHCSLXlhtpMYFFRCHLSFLDLCYTISTVPQLLVNLhgahQIITYggCVTQLFIT 102
gi 38372773   25 PVLFALVLLCYLLTLTGNSALVLLAVRDPRlhtpMYYFLCHLALVDAGFTTSVVPPLLANLrgpaLWLPRshCTAQLCAS 104
gi 47576669   23 KRLFIVVLISYLLTLVGNTIIILISSIDSKlktpMYYFLTHLSFVDICFTTSIVPQLLWNLkgpaKTITAvgCVVQLYVS 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 38372774  105 LALGSTECVLLVVMAFDRYAAVCRPLhYMAIMhPHLCQTLAIASWGAGFVNSLIQTGLamaMPLCGH-RLNHFFCEMPVF 183
gi 395533739 103 LALGSAECVLLVGMAFDHYVAVCQPFqCTTTMqPWLCFLLATISWFGGFVNSVAQTGLxitILLCGLhYLDHFFCEMPVF 182
gi 38372773  105 LALGSAECVLLAVMALDRAAAVCRPLrYAGLVsPRLCRTLASASWLSGLTNSVAQTALlaeRPLCAPrLLDHFICELPAL 184
gi 47576669  103 LTLGSTECILLAVMAFDRYAAVCKPLhYVAVMnPQLCQALAGISWLSGVGNALIQGTItlwLPRCGHrWLHHFFCEVPSM 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                            #  ## ##  # 
gi 38372774  184 LKLACadt-egTEAKMFVARVIVVAVPAALILGSYVHIAHAVlrvksTAGRRKAFGTCGSHLLVVFLFYGSAIYTYLQSi 262
gi 395533739 183 LKLACkdr-eqTKVKMFVARVIILVLPASFTLGSYICVVHTVlniksTARQRKAFETCGSHLMVVFLFYGSAICTCLQPi 261
gi 38372773  185 LKLACggdgdtTENQMFAARVVILLLPFAVILASYGAVARAVccmrfSGGRRRAVGTCGSHLTAVCLFYGSAIYTYLQPa 264
gi 47576669  183 IKLACvdi-haNEVQLFVASLVLLLLPLALILTSYGHIAKEVlriksSQAWHRALGTCGSHLMVVSLFYGSITVIYIQPn 261
                        250       260       270
                 ....*....|....*....|....*....|....*...
Feature 1            ## ###  #  ##                     
gi 38372774  263 hnYSEREGKFVALFYTIITPILNPLIYTLRNKDVKGAL 300
gi 395533739 262 hrYSTSHGKFAALFYTIMTSMLNPLIYTLRNKDMKAAL 299
gi 38372773  265 qrYNQARGKFVSLFYTVVTPALNPLIYTLRNKKVKGAA 302
gi 47576669  262 ssYAHTHGKFISLFYTVMTPTLNPLIYTLRNKEVKGAL 299

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap