Conserved Protein Domain Family
7tmB2_ETL

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cd15437: 7tmB2_ETL 
Epidermal Growth Factor, latrophilin and seven transmembrane domain-containing protein 1; member of the class B2 family of seven-transmembrane G protein-coupled receptors
ETL (EGF-TM7-latrophilin-related protein) belongs to Group I adhesion GPCRs, which also include latrophilins (also called lectomedins or latrotoxin receptors). All adhesion GPCRs possess large N-terminal extracellular domains containing multiple structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, coupled to a seven-transmembrane domain. ETL, for instance, contains EGF-like repeats, which also present in other EGF-TM7 adhesion GPCRs, such as Cadherin EGF LAG seven-pass G-type receptors (CELSR1-3), EGF-like module receptors (EMR1-3), CD97, and Flamingo. ETL is highly expressed in heart, where developmentally regulated, as well as in normal smooth cells. Furthermore, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions.
Statistics
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PSSM-Id: 320553
View PSSM: cd15437
Aligned: 4 rows
Threshold Bit Score: 471.668
Threshold Setting Gi: 38511442
Created: 11-Nov-2013
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative polypeptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on mutagenesis of human glucagon receptor (GCGR), and modeling studies of GCGR and other related class B GPCRs
  • Comment:Residues in the globular N-terminal extracellular domain and the extracellular loops of the 7TM domain may also be involved in ligand binding.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #   #                                         #  ##  #      #      #     
gi 212276505 424 YNILTRITQLGIIISLICLAICIFTFWFFSEIQsTRTTIHKNLCCSLFLAELVFLVGINTNtnKLFCSIIAGLLHYFFLA 503
gi 32766655  460 YNVLTRITQLGMVISLICLSMCIFTFWFFRDIQnTRTTIHKNLCCSLFMAQFIFLIGINKSahKWFCSLIAGLLHYFFLA 539
gi 38511442  467 HSVLSRITQFGIIISLICLSLCIFTFLFFSEIQsTRTTIHKNLCCALFLAELLFIIGINMTknKLFCAVVAGLLHYFFLA 546
gi 465964119 488 YNILTRITQLGIIISLICLSMCIFTFWFFSEIQsTRTTIHKNLCCSLFLAELIFLVGINMNnnKLFCSITAGLLHYFLLA 567
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          ## # #        
gi 212276505 504 AFAWMCIEGIHLYLIVVGVIYNkGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGttkVCWLStENNFIWSFIGPACLIIL 583
gi 32766655  540 AFAWMCIEGIHLYLIVVGVIYNkGFLHRNFYAFGYGSPAVVVAISATLGYKYYGtssVCWLStENNFIWSFIGPPILIIL 619
gi 38511442  547 AFAWMCIEGIHLYLIVVGVIYNrGFLHKNFYIFGYCSPAVVVGISAILGYKYYGtdkVCWLStENNFIWSFIGPACLIIL 626
gi 465964119 568 AFAWMCIEGIHLYLIVVGVIYNkGFLHKNFYIFGYVSPAVVVGISAALGYKYYGtteVCWLStKNNFIWSFIGPACLIIL 647
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #  #           #   #             
gi 212276505 584 VNLLAFGVIIYKVFRHTAGLKPevscFENIRSCARGALALLFLLGTTWIFGVLHVVHaSVVTAYLFTVSNAFQGMFIFLF 663
gi 32766655  620 VNLLAFAVIIYKVYRHTAVKKPeishYENIRSCARGAIALLFVLGVTWAFGVMYILYeTTLTAYLFTFANVFQGMFIFIF 699
gi 38511442  627 VNLMAFGVIIYKVFRHTTMLKPevtcYENIRSCARGALALLFLLGATWMFGVLHVVNgSVVTAYLFTISNAFQGMFIFIF 706
gi 465964119 648 VNLLAFGVIIYKVFQHTAMLKPevscYENIRSCARGALALLFLLGATWIFGVLHVVQgSVVTAYLFTIFNAFQGMFIFIF 727
                        250
                 ....*....|....*...
Feature 1                          
gi 212276505 664 LCVLSRKIQEEYYRLFKN 681
gi 32766655  700 LCVLSRRIQEEYYRLFKN 717
gi 38511442  707 LCVLSKKIQEEYYRLFKN 724
gi 465964119 728 LCVLSRKMQFKKCYSGFR 745

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