1EG4


Conserved Protein Domain Family
EFh_DMD_DYTN_DTN

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cd15901: EFh_DMD_DYTN_DTN 
Click on image for an interactive view with Cn3D
EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
The dystrophin/dystrobrevin/dystrotelin family has been characterized by a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils. Dystrophin is the founder member of this family. It is a sub-membrane cytoskeletal protein associated with the inner surface membrane. Dystrophin and its close paralog utrophin have a large N-terminal extension of actin-binding CH domains, up to 24 spectrin repeats, and a WW domain. Its further paralog, dystrophin-related protein 2 (DRP-2), retains only two of the spectrin repeats. Dystrophin, utrophin or DRP2 can form the core of a membrane-bound complex consisting of dystroglycan, sarcoglycans and syntrophins, known as the dystrophin-glycoprotein complex (DGC) that plays an important role in brain development and disease, as well as in the prevention of muscle damage. Dystrobrevins, including alpha- and beta-dystrobrevin, lack the large N-terminal extension found in dystrophin, but alpha-dystrobrevin has a characteristic C-terminal extension. Dystrobrevins are part of the DGC. They physically associate with members of the dystrophin family and with the syntrophins through their homologous C-terminal coiled coil motifs. In contrast, dystrotelins lack both the large N-terminal extension found in dystrophin and the obvious syntrophin-binding sites (SBSs). Dystrotelins are not critical for mammalian development. They may be involved in other forms of cytokinesis. Moreover, dystrotelin is unable to heterodimerize with members of the dystrophin or dystrobrevin families, or to homodimerize.
Statistics
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PSSM-Id: 319999
View PSSM: cd15901
Aligned: 18 rows
Threshold Bit Score: 158.589
Threshold Setting Gi: 242001266
Created: 15-Oct-2014
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:EF-hand-like motif [structural motif]
Evidence:
  • Comment:The EF-like motifs don't contain the canonical pattern of calcium binding residues.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ###############      #######################                                    
1EG4_A         80 SLSAACDALDQHNLKq-----NDQPMDILQIINCLTTIYDRLEQehnn-----lvnVPLCVDMCLNWLLNVYDTGRTGRI 149
gi 13626370    54 DIWNMIEAFRDNGLNtl---dHTTEISVSRLETVISSIYYQLNKrlpst---hqisVEQSISLLLNFMIAAYDSEGRGKL 127
gi 156630439   36 DSSLIQQVLLRPSFWe----aRKHSLSVQQLSQALQELFQKAREenp------gqvHPRAPELTLSLLTTMYNSKGTGFL 105
gi 74873395    81 PYKLVLAILDRHNLSg----gLELMVPPFQLTSLLHDVYFACEKlghfnq-danykLDRATGLLANFFWNVYDPQRRHSI 155
gi 443713742   79 DLKAFSTVLDRYDYQh----tSVKRLPCENLVKIVNETCIGAKIqllgssavtndlSSTTVHLLVNWLLNICDKKRSGNI 154
gi 514693524  121 HLSDVLNAFYALEYTphnaqgQPETLRADEMATVLLEVFSKLPN------------PLSHVEIMVSWLLQTYDRERTGRV 188
gi 167516642  125 KLPTALNAFYALDVHsd--ysSGQQIDAEEMAVVLMEMYADLPH------------PQRNVEVMISMMLKIYDRNRSGHI 190
gi 918339473   69 PIDKVRNVFKQHGCPq----gEDPLLNCHDLNEILRDLFADCQHprld-----kttNIRSSDLIQNFILNLYDRQRRGVV 139
gi 524897300   81 TIEGMKHVFPLSFVEed---dLTMTVNCGEASGLLYRLLEFSDKrhqh-----tadYERATDLVLNFLLNLYDTNRSGKL 152
gi 242001266  122 HVSMLPGVFGCRGLEgs--gqQELLLGCSQAEAVLEELYRRAPGvhq-------qkVPLLAALALNLLQNLFDAKRKGTI 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1EG4_A        150 RVLSFKTGIISlck-ahLEDKYRYLFKQVa-------sSTGFCDQRRLGLLLHDSIQIPRQlgevas--fggsniEPSVR 219
gi 13626370   128 TVFSVKAMLATmcg-gkMLDKLRYVFSQMs-------dSNGLMIFSKFDQFLKEVLKLPTAvfegp----sfgytEHSVR 195
gi 156630439  106 QLMPAAAALITlsg-dsPLSKYRALFQLYaensrggydSGPRMTRRVLRKLLTDLQQIPTFvgesr----alcpvESATR 180
gi 74873395   156 SLLEIRITFILlcklysSDHLVGDIFGLLad------pKSQIISRYAFEQLLATLSKLLSYlgeaka--ygvhnlPLAME 227
gi 443713742  155 DLLTFKVAMGTlcn-asLSSKYKFFFNQIc-------dLSRCVPKANLLKFIKTMLQVAAQfgenss--fgglnaQPAVD 224
gi 514693524  189 PLLSLKIALSTlct-swIEEKYRYAFGLLdn------nADGMITREQLAFYITATLQMLKPireaypfgpspeqiQQAVD 261
gi 167516642  191 SLQAFQTALTLlsv-swIEEKYRFLFTIYdt------nQDDFITVEQLTQLLRHVVGLPNGireayafcptkefpEQEAH 263
gi 918339473  140 HALSVKTALAAmcg-gqLGEKYKYFYEEIs-------dPSTFIDCSVLSSFLVALMRIPDLihegia--ygglnsTPALE 209
gi 524897300  153 VLRSMRNALTAlcp-skLCDKYRYFFAGLr-------dGSGRISREKFLYFIDDLMQITDTikesta---fgrnlTAAVD 221
gi 242001266  193 QVVQMKVALFVlca-grLLDKLKYMCGELq-------dGSQRIPLEGLEAFLHNISKVPELlgekls--fgahlvPAAVE 262
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
Feature 1                                                  
1EG4_A        220 SCFQF-----ANNKPeie--------------aaLFLDWMR 241
gi 13626370   196 TCFPQ-----QRKIMl-----------------nMFLDTMM 214
gi 156630439  181 SCFQG-----VLSPAik---------------eeKFLSWVQ 201
gi 74873395   228 QCFAR-----CPHGVggl-------------tepQFHKLWT 250
gi 443713742  225 SCFSG-----AWSSTgvt--------------edEFLAWLN 246
gi 514693524  262 NCCQL-----ERERSgvpdam--------lisleTFVEWCM 289
gi 167516642  264 RVFEL-----ERERNgaaat---------qislnTFVNYCM 290
gi 918339473  210 SCLQM-----SDCKYgis--------------edMFYAWLY 231
gi 524897300  222 SCFKLe---tSSSPLtvs--------------edTFYSWLL 245
gi 242001266  263 SCRKVrvqpfAGHRApvtapfprqlcsqpsvpsdLFLGWLL 303

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