Conserved Protein Domain Family
7tmA_GPR162

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cd15906: 7tmA_GPR162 
G protein-coupled receptor 162, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup represents the orphan G-protein coupled receptor 162 (GPR162), also called A-2 or GRCA, with unknown endogenous ligand and function. Phylogenetical analysis indicates that GPR162 and GPR153 share a common evolutionary ancestor due to a gene duplication event. Although categorized as members of the rhodopsin-like class A GPCRs, both GPR162 and GPR153 contain HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors and important for efficient G protein-coupled signal transduction. Moreover, the LPxF motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in GPR162 and GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320572
View PSSM: cd15906
Aligned: 3 rows
Threshold Bit Score: 500.653
Threshold Setting Gi: 301624884
Created: 20-Nov-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##                 #
gi 74754516   14 RSNALSWLACGLLALLANAWIILSISAKQQkh---kpLELLLCFLAGTHILMAAVPLTTFAVVQLRRQassDYDWNESiC 90
gi 118083302  11 HNNSLWWLACGMLALLANSWIILSITAKQQkh---kpLELLLCFLAGTHILMAAVPLTTYAVVQLRREs-sNYDWNESiC 86
gi 301624884  15 QNNSLSWLACGALALLANGWSILSLASRGGsgqrprpLELLLCLLAGTHLLMAAIPLSLFSVVQLRHKh-sGYEWNEGlC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##### ##  #                                            # #####                  
gi 74754516   91 KVFVSTYYTLALATCFTVASLSYHRMWMVRWPvnYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYargCQF 170
gi 118083302  87 KVFVSTYYTLALATCFTVASLSYHRMWMVRWPvnYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNGERYYargCQF 166
gi 301624884  94 KVFVSTYYTLALSTCLTVACLSYHRMWMVRWPvsYRLGGARRQALQGALGIWAASFVLSTLPSIGWHDNARRFYtrgCHF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  ### ### ##                                                             
gi 74754516  171 IVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWarprrarqarrvgggggtkaggpgalgtrpaFEVPAIVVEDAR 250
gi 118083302 167 IVSKIGLGFGVCFSLLLLGGIVMGLVCVGITFYQTLWahrrrrqcchqrp------eeasscssahntFNVPAIVVEDVR 240
gi 301624884 174 LASRIGLGFGLCFQLLLLGGVGTGLGCLGVTIYHACCcpasgqrgg-------------ageggvegkIEVPAIVVQDAQ 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         #  ## ##  #       ## ###  #  ##                
gi 74754516  251 GKRRSSLDGSesAKTSLQVTNLVSAIVFLYDSLTGVPILVVSFFSLKSDsaPPWMVLAVLWCSMAQTLLLPSFIWSCERY 330
gi 118083302 241 GKRRSSLDGSesAKTSLQMTNLISAIVFLYDTLTGVPILVVSFFSLRYDtaPTWMVLAVLWCSMVQTLLLPSFIWSCERY 320
gi 301624884 241 GKRRSSLDGSesPRTAAQVTGLVGGIVLLYDALTGLPILVVSFVSLRYDstPPWMVLCVLWCSMAQTLLLPSFIWSCARY 320

                 ....*
Feature 1             
gi 74754516  331 RADVR 335
gi 118083302 321 RADLR 325
gi 301624884 321 RADLR 325

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