Conserved Protein Domain Family
7tmA_GPR153

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cd15907: 7tmA_GPR153 
orphan G protein-coupled receptor 153, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup represents the G-protein coupled receptor 153 (GPR153) with unknown endogenous ligand and function. GPR153 shares a common evolutionary origin with GPR162 and is highly expressed in central nervous system (CNS) including the thalamus, cerebellum, and the arcuate nucleus. Although categorized as a member of the rhodopsin-like class A GPCRs, GPR153 contains HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors and important for efficient G protein-coupled signal transduction. Moreover, the LPxFL motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Statistics
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PSSM-Id: 320573
View PSSM: cd15907
Aligned: 5 rows
Threshold Bit Score: 632.754
Threshold Setting Gi: 81170632
Created: 20-Nov-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #  ##                #####
gi 81170632    8 PGSAVGWLVCGGLSLLANAWGILSVGAKQKkwkpLEFLLCTLAATHMLNVAVPIATYSVVQLRRQrpDFEWNEGlCKVFV 87
gi 556971969  77 HNNALAWLICSGVSLLANTWGILSVSAKQKkwkpLEFLICTLAGTHILNMGIPIIMYSVIQLRRQhsNYEWNEGlCKVFV 156
gi 47220421   11 KANTLAWLVCSGVSILANTWSILSVSAKQKkwkpLEFLICTLAGTHILNMAIPITMYCVITLRRQhsNYEWNEGlCKVFV 90
gi 591351517  15 HNNAVAWLVCSGVSVLANAWGILSVSAKQKkwkpLEFLICTLAGTHILNIAVPITMYAAIELRRQrsDYEWSEGlCKAFV 94
gi 189230061   8 HNNAIAWLICSGISLLANTWGILSISAKQKkwkpLEFLICTLAGTHILNVAIPITMYSVVQLRRQhsDYEWNEGlCKVFV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # ##  #                                            # #####                      
gi 81170632   88 STFYTLTLATCFSVTSLSYHRMWMVCWPvnYRLSNAKKQAVHTVMGIWMVSFILSALPAVGWHDTSERFYthgCRFIVAE 167
gi 556971969 157 STFYTLTLVTCFSVTSLSYHRMWMVRWPvnYRLSNTKKQAVHTVMGIWMVSFILSTLPAVGWHDTTQRFYdqdCQFIVTE 236
gi 47220421   91 STFYTLTLVTCFSVTSLSYHRMWMVRWPvnYRLSNTKKQAVHTVMGIWMVSFILSTLPAVGWHDTMDRFYtsdCRFIVTE 170
gi 591351517  95 STFYTLTLVTCFSVTSLSYHRMWMVRWPvnYRLSNTKKQAVHTVMGIWMVSFILSTLPAVGWHDTTERFYardCRFIVTE 174
gi 189230061  88 STFYTLSLVTCFSVTSLSYHRMWMVRWPvnYRLSNTKKQAVHTVMGIWMVSFILSTLPAVGWHDTTERFYardCRFIVTE 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #  ### ### ##                                                                 
gi 81170632  168 IGLGFGVCFLLLVGGSVAMGVICTAIALFQTLAvqvgrqadrraFTVPTIVVEDAQGKRRSSIDGSepAKTSLQTTGLVT 247
gi 556971969 237 IGLGFGVCFLLLISGSVVMGVVCIGIALFQTFSiqtgntidknqFNVPTIVVEDAQGKRKSSIDGSepIKTSLQITYLIS 316
gi 47220421  171 IGLGFGVCFLLLIGGSVAMGVICIGIALFQTFSihaghnadknkFNVPTIVVEDAQGKRRSSIDGSepLKTSLQITYLIS 250
gi 591351517 175 IGLGFGVCFLLLISGSVAMGVVCTSIALFQTFSvqmghsidrnkFNIPAIVVEDAQGKRRSSIDGSepIKTSLQITYLVT 254
gi 189230061 168 IGLGFGVCFLLLISGSVVMGVVCIGISLFQTFSiqtgqnidknkFNVPTIVVEDAQGKRRSSIDGSepIKTSLQITYLIS 247
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                 #  ## ##  #       ## ###  #  ##                     
gi 81170632  248 TIVFIYDCLMGFPVLVVSFSSLRADasAPWMALCVLWCSVAQALLLPVFLWACDRYRADLK 308
gi 556971969 317 GIVFIYDFLTGFPILVVSFTSLRYDksYDWMVLCVLWCSIVQSILLPIFLWACARYRADIK 377
gi 47220421  251 GIVFIYDFLTGFPILVVSFASLKFDrsYNWMVPCVLWCSIAQSILLPMFLWACDRYRADIR 311
gi 591351517 255 GIVFIYDFLMGFPILVVSFASLKSDtsYNWMVVCVLWCSVIQSLLLPLFLWACDRYRADVR 315
gi 189230061 248 GIVFIYDFLMGFPILVVSFASLKLDksYEWMVLCVLWCSVVQAMLLPMFLWACDRYRADVK 308

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