Conserved Protein Domain Family
7tmA_OR11G-like

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cd15913: 7tmA_OR11G-like 
olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320579
View PSSM: cd15913
Aligned: 17 rows
Threshold Bit Score: 418.643
Threshold Setting Gi: 602643292
Created: 23-Jul-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ######
gi 212276448  63 ILLFVLFTVVYLLTLMGNGSIICAVHWDQRlh-apMYILLANFSFLEICYVTSTVPSMLANFls-dtKIISFsgCFLQFY 140
gi 345287218  29 ILLFSFFFVIYVLTLTGNLCIISAVWWDEYlh-tpMYILLANFSFLEIWYVTSTVPNMLANLls-etSTISFygCFLQFY 106
gi 47576491   27 IFLFSVFFMIYILTLLGNMAIVYAVHWDHRlh-tpMYILLANFSFLEICYVNSDVPNMLVNFls-ttKTISFtqCLLQLY 104
gi 432112917 125 ILLFVFFSFIYLLTLLGNTSIICAVWSSRKlh-tpMYILLANFSFLEICYVSSDVPKMLANIis-qtKSISYtgCLLQFY 202
gi 444724833  28 LLYFGLFSVTYTLTLMGNAAIACAVRWDRRlh-tpMYILLGNFSLLEICYVTTTVPNMLANFls-tsKSISFvsCFAQFY 105
gi 345313650  29 PLLFSFFSASYALTLLGNGAIVCAVRRDRRlh-tpMYLLLGSFSFLEICYVTSTVPNMLANIls-etKAISLagCFLQFY 106
gi 444724839  56 VILFMFFSIVYLLTLMGNIAIICAVCWNQHlh-tpMYILLGNFAFLEIWYVNATVPNTLVNFls-dtKAISFtgCFLQLY 133
gi 440894291  31 ILLFVFFSIIYILTLLGNSAIICAVWWDQQlh-tpMYILLAIFSFLEICYINSNVPSMLFNFls-ktKTISYhgCILQFY 108
gi 530647445  18 TLFCALLSAAYTGTLAGNLCILWAVLQDPHlqrlpMYILLGNFSWLEICYVTATVPRMLSDLvs-pgIPISFqaCFVQFY 96
gi 602643294  50 LFLCSLLSICYAFTLVGNLCIVWAVLWDSQlsqlpMYILLGNFSALEMGYVTTTAPRMLLDLasplpGVISFhgCFLQFY 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                       
gi 212276448 141 FFFSLGSTECFFLAVMAFDRYLAICRPlrYPTIMtRRLCTNLVVNCWVLGFIWFLIPIVNisqMSFCGSrIIDHFLCDPA 220
gi 345287218 107 FFFSMGTTETFFLSAMAFDRYLAICRPlhYSTVMtVQRCIRIGAGCWVCGFSCFLLPVYLisqLPFCGPnTIDHFLCDPG 186
gi 47576491  105 FFFSLGTTECLFLSIMAYDRFLAICRPlyYPTVMtTRFCGNLVIFCWVYGFLWFLIPVILitqLPFCGPnVIDDFLCDLG 184
gi 432112917 203 FFFSMCAAEGLFLSVMSFDRFLAICRPlhYPTIMtHRLCAQLVIFCWAGGFLWLLTPLTLvsqVPFCGPnTIDHFLCDLA 282
gi 444724833 106 FFCTFGCDEGFFLCIMAFDRYLAICRPlhYPRIMtRQLCTGLVIFGWSCGFIIFLTPVVLisqLSYCGPnVINHFMCDPV 185
gi 345313650 107 CFFSLGTTETFHLSVMAFDRFLAICRPlrYPSIMtPQLCTLLVVTCWVGDFLCFVLPVYLvarLPFCSPrVIDHFLCDPG 186
gi 444724839 134 FFFSMGSTECFFLSVMAFDRYFAICRPlhYATIMtGQRCIHLVISCWVCGFLWYLVPVILishLPFCGPnVIDHFVCDSG 213
gi 440894291 109 IFLSLCATELFFLALMAFDRYVAICRPlhYPTIMtRKVCGTLVSASWVGGFLWLVTPAALisqVPFCGSnVIDHYLCDLG 188
gi 530647445  97 FTFSMGATECFFLVVMALDRYLAICHPlhYPLLMcPKLCWALVASCWLSGFLWFIVPVALisqLSFCGSnTLDHFVCDLA 176
gi 602643294 130 FFFSMGTTESFLLAAMALDRYLAICHPlrYPVLMsQRFCCILAAFCWASGFLWFLAPIILisqLHFCGSnLLDHFICDPG 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #  ### ### ##                                            #  ## ## 
gi 212276448 221 PLLTLTCKKgp--vIELVFSVLSPLPVFMLFLFIVGSYALVVRAVLrvpsaAGRRKAFSTCGSHLAVVSLFYGSVLVMYG 298
gi 345287218 187 PLMKLSCVPat--aTEVICAVFNSVLIFSTFLFITSSYTLVIRAVLrvpsaEGRHKAFSTCGSHLAVVSLFYGSIMVMYV 264
gi 47576491  185 PLLALASVCvpipgTVLICGTMSSLLIFGTFFYIIGSYTLVLRAVIrmpssAGSKKAFSTCSSHLAVVFLFYGSVMITYV 264
gi 432112917 283 PLLALSCAPvs--gITLACGIISSLIIFLTFLYILGTYFCVLSVVLqvpsgAGRHKAFSTCASHLTVVSLFYGSVMVMYV 360
gi 444724833 186 PLMMLSCSEdt--tTQLIYSSLNSFFMISTFVFILCSYALVLLAVVrmpseSGKQKAFSTCASHLAVVTLFYGSIMMMYI 263
gi 345313650 187 PLLALSCTPap--gVELTCAGLSSLLLLSTLVFILGSYALVLRAVLrvpsaAGRRKAFSTCGSHLAVVALFYGSVMGTYV 264
gi 444724839 214 PLLTLSCTPap--mSKLISYTLSSLIILLSFLFIVISYALVLLAVLqlplaSSRHKAFSTCGSHLVVVLLFYGTIMVMDV 291
gi 440894291 189 AMLAISCVPvp--kTALTCSTFSAVITFITLFYILVSYTLVLRAVIqvpkgPSRRKAFSTCTSHLIVVFLFYGSVTVMYV 266
gi 530647445 177 PLLAASCTPap--rTEQTCYALSSLIMFTTVLFILASYGLVVRAVLrlpsgAKQHKAFSTCTSHLAVVGLFYGSVMVMYV 254
gi 602643294 210 PLLASSCTPap--gTELAFYSLSSIAIFGPFLFIACSYIALLRAVMrlssaTGRQKAFSTCTSHMIVVSLFYGSIMVTYV 287
                        250       260       270
                 ....*....|....*....|....*....|....
Feature 1         #     ## ###  #  ##              
gi 212276448 299 SPpsknEAGKQKTVTLFYSVVTPLLNPVIYSLRN 332
gi 345287218 265 SPtagnPAGIQKIVTLFYSVMTPLFNPLIYSLRN 298
gi 47576491  265 SPgsgqAKGMQKFTTLFYSVLTPFFNPMIYSLRN 298
gi 432112917 361 SPgsgnYSGMQKFVTLFYALATPFFNPLIYNFRN 394
gi 444724833 264 SPesghPVEMQKIITLFYSVITPLCNPLIYSLRN 297
gi 345313650 265 SPgagsPGGGQKVVTLFYSVLTPLCNPLIYSLRN 298
gi 444724839 292 SPgfshSTLMSKIMTLFYAMVTPLFNPLIYSLRN 325
gi 440894291 267 SPgvasQPGLQKFLTMLYSIATPLLNPLIYSLRN 300
gi 530647445 255 NPa--aSGDSGKVVTLFYAVGTPLLNPLIYSLKN 286
gi 602643294 288 VPe--aSGGSNKVVTLLYSVLTPLLNPLIYSLRN 319

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