Conserved Protein Domain Family
7tmA_OR6N-like

?
cd15914: 7tmA_OR6N-like 
olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
?
PSSM-Id: 320580
View PSSM: cd15914
Aligned: 10 rows
Threshold Bit Score: 406.757
Threshold Setting Gi: 301627224
Created: 23-Jul-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372788   25 IYLFLLLLLIYLMTVLGNLLIFLVVCLDSRlhtpMYHFVSILSFSELGYTAATIPKMLANLlsekKTISFsgCLLQIYFF 104
gi 465957987  25 TFLFALLLLIYLFAIFGNVVIFTVIRSDARlhtpMYFFISSLSFLEIWYTAVTIPKMLSNLlskrKSISFtgCLLQTYFF 104
gi 223590118  53 LLFFIPLLLIYGFILTGNLIMFIVIQVGMAlhtpLYFFISVLSFLEICYTTTTIPKMLSCLiseqKSISVagCLLQMYFF 132
gi 47576447   25 LLLFILLLCVYLFIVIGNSMIFLAVQLDVRlhnpMYSFISIFSFLEICYTTVTIPKMLYNLvsreKTISLigCLLQMYFF 104
gi 229462932  41 LLYFFPLLFIYTFIIIDNLLIFSAVRLDTHlhnpMYNFISIFSFLEIWYTTATIPKMLSNLisekKAISMtgCILQMYFF 120
gi 38372789   25 GWLFVLLLLAYLFTICGNMLIFSVIRLDAAlhtpMYHFVSVLSFLELWYTATTIPKMLSNIlsekKTISFagCLLQTYFF 104
gi 38372786   25 VVCFVPLLFIYAFIVVGNLVIITVVQLNTHlhtpMYTFISALSFLEIWYTTATIPKMLSSLls-eRSISFngCLLQMYFF 103
gi 465960252  25 LLLFNLLLFTYVLILGGNTVILMLIRANPHlhvpMYYFVAILSFLEVWYTTVTIPKMLANLldsrKPISYrgCLLQVYFF 104
gi 301627224  25 LLLFPFFFIIYLFIICGNVTIITLICSHQSlqvpLYFFVAVLSFLEIWYTTVTIPKMLASLld-qKNISYnsCLAQVYFL 103
gi 512857049  25 PLLFTVLLVIYLFIITGNTLICFVVKKEHSlhspMYFFICTLSLTELCYTGVTIPTMLANLleeeKKISLkgCLLQAYFL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 38372788  105 HSLGATECYLLTAMAYDRYLAICRPlhYPTLMtPTLCAEIAIGCWLGGLAGPVVEISLisrLPFCGPnRIQHVFCDFPPV 184
gi 465957987 105 HSLGATECYLLTAMAYDRYLAICNSlrYPAIMtPKVCTHLAASCWICGFMCPVIEVILvskLPFCGPnEIQHIFCDFPPL 184
gi 223590118 133 HSLGITESCVLTAMAIDRYIAICNPlrYPTIMiPKLCIQLTVGSCFCGFLLVLPEIAWistLPFCGSnQIHQIFCDFTPV 212
gi 47576447  105 HSFGVTEGLVLTMMAIDRYVAICNPlcYTIIItPKLCTQLSTGSFTLGFLMLLPEIVWmstLPFCGPnQIHQLFCDLEPV 184
gi 229462932 121 HSLENSEGILLTTMAIDRYVAICNPlrYQMIMtPRLCAQLSAGSCLFGFLILLPEIVMistLPFCGPnQIHQIFCDLVPV 200
gi 38372789  105 HSLGASECYLLTAMAYDRYLAICRPlhYPIIMtTTLCAKMAAACWTCGFLCPISEVILasqLPFCAYnEIQHIFCDFPPL 184
gi 38372786  104 HSTGICEVCLLTVMAFDHYLAICSPlhYPSIMtPKLCTQLTLSCCVCGFITPLPEIAWistLPFCGSnHLEHIFCDFLPV 183
gi 465960252 105 HALGITEACLLTAMAYDRYLAICKPlhYPSTMtPKSCLWLVAGCWACGFMWPVPEIILlftLPFCGAhRIEHLFCDFPSL 184
gi 301627224 104 HCLGITETYLLTAMAYDRYLAICNPlrYSSIMtNRCCLQLSACCWLTGLLGPITQITLlsrLHFCNAnKIEHIFCDFNPL 183
gi 512857049 105 HSFGSAECYLLTTMAYDRYLAICKPlhYSSIMtMGLFIKLAAACIISGFLSPVIGAFLissLPFCGPnCIQTLFCDFLPL 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #  ### ### ##                                            #  ## ##  #
gi 38372788  185 LSLACTDts--iNVLVDFVINSCKILATFLLILCSYVQIICTVLripsaAGKRKAISTCASHFTVVLIFYGSILSMYVQL 262
gi 465957987 185 LSLACTDts--iNVLVDFIVNAFIILVTFLFIMVSYIKIIKAILkirtaEGREKAFSTCAAHLTVVLLFFGSIIFMYVRL 262
gi 223590118 213 LSLACTDt---fLVVIVDAIHAAEIVASFLVIALSYIRIIIVILgmhsaEGHHKAFSTCAAHLAVFLLFFGSVAVMYLRF 289
gi 47576447  185 LLLACTDt---sMILVEDVIHAISILSCVSIITLSYLKIITVVLkipsgESRQKAFSTCTAHITIFVLFFGSVSLMYLRF 261
gi 229462932 201 LSLACTDt---sMILIEDVIHAVTIIITFLIIALSYVRIVTVILripssEGRQKAFSTCAGHLMVFPIFFGSVSLMYLRF 277
gi 38372789  185 LSLACKDts--aNILVDFAINAFIILITFFFIMISYARIIGAVLkiktaSGRKKAFSTCASHLAVVLIFFGSIIFMYVRL 262
gi 38372786  184 LRLACTDtraivMIQVVDVIHAVEIITAVMLIFMSYDGIVAVILrihsaGGRRTAFSTCVSHFIVFSLFFGSVTLMYLRF 263
gi 465960252 185 LSLACADvs--tSTTIDFALHSLVILGPTALILFSYVKILSVVIkiqgsEGRRKAFSTCASHLTMVLAFFGTTGFMYIRP 262
gi 301627224 184 ISLACSDtt--lNVRVDFYINSFLLFLAFACIILSYVKIISAVLristeKGRKRTFSTCSAHLTVVILFFGSVTFTYIRL 261
gi 512857049 185 IALACTDtk--lHVLVEFVVGSVIILLSCIFVLQSYSRIIHVILkiksrKGRQKTFSTCGAHLIVVVLFFGSISFTYIRL 262
                        250       260       270
                 ....*....|....*....|....*....|..
Feature 1             ## ###  #  ##              
gi 38372788  263 kksySLDYDQALAVVYSVLTPFLNPFIYSLRN 294
gi 465957987 263 kksySLDYDRAFAVIYAVLTPLANPVIYSLRN 294
gi 223590118 290 satySVFWDTAIAVTFVILAPFFNPIIYSLKN 321
gi 47576447  262 svtfQPLLEKMIALMFAVLAPFFNPIIYSLRN 293
gi 229462932 278 sdtyPPVLDTAIALMFTVLAPFFNPIIYSLRN 309
gi 38372789  263 kksySLTLDRTLAIVYSVLTPMVNPIIYSLRN 294
gi 38372786  264 satySLFWDIAIALAFAVLSPFFNPIIYSLRN 295
gi 465960252 263 arsqPSYHDRVVAVVYAVLTPLFNPLIYSLRN 294
gi 301627224 262 tknyPLNYNYSMAVIYSVLTPMCNPVVYSLRN 293
gi 512857049 263 sesySADYDRAVGVAYAIFTPLANPVIYGLRN 294

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap