Conserved Protein Domain Family
7tmA_OR12D-like

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cd15915: 7tmA_OR12D-like 
olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320581
View PSSM: cd15915
Aligned: 16 rows
Threshold Bit Score: 402.069
Threshold Setting Gi: 512817535
Created: 11-Sep-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 14423826   23 PFFFGIFLIIYLINLIGNGSILVMVVLEPQLhsPMYFFLGNLSCLDISYSSVTLPKLLVNLVcsRRAISFlGCITQLHFF 102
gi 301627230  25 CIVYGIFLLFYCLTLLGNLSIMITTIRDSNLhtPMYFFLWNLSFIDIGFSSVSVPKMLMDFFatRKLISFgGCMSQICFF 104
gi 301627228  90 ITLFGVFLAFFLLNLTGNISILVITILEKALhtPMYYFLGNIAFFDIFVSYVTVPKMLTDFFflQKTISFnSCISQLHFF 169
gi 512864400  25 TVLFLVFLVLYMFTLLGNICIMAAVIIDRHLhtPMYFFLSNLSFFDIVYSSTTVPKMMSALVleESKISVqNCIVQIYFF 104
gi 440898860  60 PVLFVIFLATYIVSLAGNGAILMVVISDSRLhsPTYFFLGNLSCLDICYSTVTLPKMLGNFLstHKTISFlGCISQLHFF 139
gi 488522677  23 PVIFMIFLFLYLMNLFGNGAIIVIVISEPRLhsPMYFFLGNLSFLDICYSSVTLPKLMSNLLstHKAISFlGCITQLHFF 102
gi 558160854  23 IFLFPLFLLLYMANVLENGAIIAVVLAEPRLhkPMYFLLGNLSFLDICFSTVAVPKLLAGFLseRQAISFaGCLVQLYFF 102
gi 602675119  39 TFLFFLFLLLYFASLLGNTTILLIALGEPRLhtPMYFFLVNLSCLDICYSTVTVPKMLAGFLvgHWRISFiGCLTQLHFF 118
gi 512817535  25 IVLFITFFFFYMFILLGNLSILAAVIIDRGLhrPMYFFLANLSCLDLFFSSTTVPKMLAGLMmgDMRISFqSCMVQLYFF 104
gi 512864011 222 IILFVCILIIYLLNLTGNFLIMLLIISDSTLhiPMYFFLWNLAFIDICYSSVVVPKMLSDLLstKRTISFiGCISQIHFF 301
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 14423826  103 HFLGSTEAILLAIMAFDRFVAICNPLrYTVIMnPQVCILLAAAAWLISFFYALMHSVMTa-------hLSFCGSQKLNHF 175
gi 301627230 105 HFFGTAEVMLLAVMSYDRFVAIGNPLrYILIMnSKVCLSLALSCWISGFFHSLLHTVMTa-------kLPYCQANLVNHF 177
gi 301627228 170 HFLAGSEVVLLTVMSYDRLIAIGNPLrYSSIIsPTFCVILIFGSWVFGFLHSLLHTVLTa-------mLPYCGPNLVEHF 242
gi 512864400 105 HFFGCTEAMLLTAMAYDRYVAICIPLrYNIIMaKSACFRLISGCWVLSLFYSLTHTILTs-------mLPFCNLDRISHF 177
gi 440898860 140 HFLGSTESMLLAMMGFDRFVAMCKPLhYTLIMnHQVCIQMAVTVWIIVFFHALLCFFHAllhsvmssrLNFCGSNRIHHF 219
gi 488522677 103 HFLGCTEAILLAIMGFDCFVDICYPLhYTIIMnPQVCALLGAVAWITSFLYALMHSVMTa-------rLNFCGSKKLNHF 175
gi 558160854 103 HLLGSSETVLLAVMAYDRYVAICNPLrYTVVMsPRACLLLAVASWASGFLHALITTVMTs-------rLHFCGSNRIHLF 175
gi 602675119 119 HFLGSSEALLLGVMAYDRYVAICNPLrYITIMnKKACIKGAIITWTTGFLHALMHTIMTs-------qVIFCGPNKVQHF 191
gi 512817535 105 HLFGCTEALLLTLMSYDRYIAICNPLrYQVLMsNRVYVQMASYCWVIGFVYSFSHTILTs-------rLPYCNMNKITHF 177
gi 512864011 302 HFLGSSEVMLFSAMSYDRYVAIQNPLrYSSIMnIRLCLQLSLGCLMLGFFHSLLHTLLIa-------kLPFCGPDVINHF 374
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #  ### ### ##                                              #  #
gi 14423826  176 FYDVKPLLELACsdtllNQWLLSIVTGSISMGAFFLTLLSCFYVIGFLlfkn-rscRILHKALSTCASHFMVVCLFYGPV 254
gi 301627230 178 FCDVKPVLKLACtdtsfILQLLTRVAGSVSTITFAFTFLSYFFIIKFViqi--rtkKGRRNAFSTCSAHLTVVFMLYGTA 255
gi 301627228 243 FCDIKPLLKLACadttlNQKILNILTGYLTCMAFLLTVISYVLIGRIIlkm--ktvEGRKRAISTCSGHLTVVILLYGTA 320
gi 512864400 178 FCDIKPLLKLACadtslNENLVTIITGFLAVSTSSLISLSYIFIGIHLvkv--rssPERHKALSTCTSHLTVVFLFYGPL 255
gi 440898860 220 FCDVKPLLELACgtielNEWLLNTVTGTIAMGSFFLTFLSYVYIIIYLffkt-hscSMLHKALSTCASHFSVVVLFFVPV 298
gi 488522677 176 FCDVKPLLELACgdtllNQWLVSIVTGSIAVGAFLLTLLSYFYIIGFLllks-rscSTLQKALSTCASHFMVVGLFYGTV 254
gi 558160854 176 WCDIKPLLSLACdsirlNLILLNIDAAVLGLISFLLTLFSYRYIISFLllkv-qsrESRRKAFSTCTSHLTVVCLLYLPV 254
gi 602675119 192 FCDIKPLLKLACcsttlNLSLLNIITGLIVLLPFILTFLSYIYIISFLflkv-ktkESRTKAFSTCASHLTVVTLFYAGA 270
gi 512817535 178 YCDIKPLLKLACantklNERLLTIISGFVSTSTFILVMISYIIIGSHLlnmpvgskQSYSKAFSTCTSHMVVVLLYFGIA 257
gi 512864011 375 FCDIKPLLKLACtdtslNLHLLNGITGTLTVITLFLTILSYIFISRCLmki--tntEGRKRAFAICSAHLTAVLLLNGTA 452
                        250       260       270
                 ....*....|....*....|....*....|....*....
Feature 1        # ##  #     ## ###  #  ##              
gi 14423826  255 GFTYIRPasatSMIQDRIMAIMYSAVTPVLNPLIYTLRN 293
gi 301627230 256 IFTYMRPltqqSLDHDRVVAVLFTVVTPALNPLIYTLRN 294
gi 301627228 321 LFTYIRPatqdILDQDRGAAVLFTVVTPALNPIIYTLRN 359
gi 512864400 256 IARFLRPatndSLEQDRQSALLYTTITPVLNPIIYALRN 294
gi 440898860 299 DFVYIHPasrsSVDQDQIIAIMYSVVIPVLNPLIYTLRN 337
gi 488522677 255 CINYISHtsadSAKQEQFVALVHTTATSVLNPLVYTLRN 293
gi 558160854 255 LGNYMIAspglTSERDMIPTLMHSIVTPVLNPLIYTLRN 293
gi 602675119 271 ILTYVPPssgeSLQQEMMVTLMYTIVTPVMNPLIYTLRN 309
gi 512817535 258 MCTYLGPsnkeTLEQDRLTALLVTVITPALNPVIYTLRN 296
gi 512864011 453 IFTYIRPssqsSLDQDRAAAVFYTVLPPALNPIIYSLRN 491

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