Conserved Protein Domain Family
7tmA_OR10G-like

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cd15916: 7tmA_OR10G-like 
olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320582
View PSSM: cd15916
Aligned: 6 rows
Threshold Bit Score: 424.939
Threshold Setting Gi: 512818002
Created: 12-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ######
gi 74760323   46 APLFLAFLVIYLLTVSGNGLIILTVLVDIRlh-rpMCLFLCHLSFLDMTISCAIVPKMLAGFll-gSRIISFggCVIQLF 123
gi 38372664   29 SLLFLVFFIIYILTQLGNLLILLTMWADPKlcarpMYILLGVLSFLDMWLSSVTVPRLILDFtp-sIKAIPFggCVAQLY 107
gi 38372736   23 APLFGIFLVVYVLTVLGNLLILLVIRVDSHlh-tpMYYFLTNLSFIDMWFSTVTVPKMLMTLvspsGRTISFhsCVAQLY 101
gi 223590111  38 SLFFLLFLLIYSITVAGNLLILLTVGSDSHls-lpMYHFLGHLSFLDACLSTVTVPKVMAGLltldGKVISFegCAVQLY 116
gi 512818002  25 IPLFTLFLCIYILTFLGNFLLVLTVIGDPHly-rpMYFFLMNLSYLDICLSTVTEPKLLTTFse-qTKAISFqgCMTQLY 102
gi 602667752  35 SLLFFIFLIIYLFTLTGNSLVLMTIWLDSRlh-kpMYIFLGHLSFLDFWFSTVTLPKMLEGFlepgGTVISFmgCLFQLY 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                       
gi 74760323  124 SFHFLGCTECFLYTLMAYDRFLAICKPlhYATIMtHRVCNSLALGTWLGGTIHSLFQTSFvFRLPFCGPNRVDYIfCDIP 203
gi 38372664  108 FFHFLGSTQCFLYTLMAYDRYLAICQPlhYPVLMnGRLCTVLVAGAWVAGSMHGSIQATLtFRLPYCGPNQVDYFiCDIR 187
gi 38372736  102 FFHFLGSTECFLYTVMSYDRYLAISYPlrYTNMMtGRSCALLATGTWLSGSLHSAVQTILtFHLPYCGPNQIQHYfCDAP 181
gi 223590111 117 CFHFLASTECFLYTVMAYDRYLAICQPlhYPVAMnRRMCAEMAGITWAIGATHAAIHTSLtFRLLYCGPCHIAYFfCDIP 196
gi 512818002 103 FFHFFGSTECFLYTVMAYDRFLAICHPlhYPTLMsLKLCTKFVTGVWVAGSVHAMIHTSLtFRLRFCGPNRIDYFfCDVI 182
gi 602667752 114 FSQLLGSTECFLYTLMSYDRYLAICHPlhYSYIMdKMKSTRLAVAMWCMGFLHSFLHTSLtFRLSFCGTMKIDHFfCDPT 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #  ### ### ##                                            #  ## ##  #
gi 74760323  204 AMLRLACADtaiNELVTFADIGFLALTCFMLILTSYGYIVAAILripsaDGRRNAFSTCAAHLTVVIVYYVPCTFIYLRP 283
gi 38372664  188 AVLRLACADttvNELVTFVDVRVVAASCFMLILLSYANIVHAILkirtaDGRRRAFSTCGSHLIVVTVYYVPCIFIYLRA 267
gi 38372736  182 PILKLACADtsaNEMVIFVNIGLVASGCFVLIVLSYVSIVCSILrirtsEGRHRAFQTCASHCIVVLCFFGPGLFIYLRP 261
gi 223590111 197 PVLKLACTDttiNELVMLASIGIVAAGCLILIVISYIFIVAAVLrirtaQGRQRAFSPCTAQLTGVLLYYVPPVCIYLQP 276
gi 512818002 183 PLLKLACEDttaNKAMIITSIGAVALMCFILIVISYIHILRTIMkirssEGRRKTFSTCASHMISVFFFYGPPLFIYLTP 262
gi 602667752 194 PLLELACTNpsiNETVIFFSIGVVALICFFLILLSYGNILRVIWnlgqaEGRSNTFSTCASHFIAMACFYIPCVFTYMRP 273
                        250       260       270
                 ....*....|....*....|....*....|....*...
Feature 1            ## ###  #  ##                     
gi 74760323  284 c-sQEPLDGVVAVFYTVITPLLNSIIYTLCNkEMKAAL 320
gi 38372664  268 g-sKDPLDGAAAVFYTVVTPLLNPLIYTLRNqEVKSAL 304
gi 38372736  262 g-sRDALHGVVAVFYTTLTPLFNPVVYTLRNkEVKKAL 298
gi 223590111 277 r-sSEAGAGAPAVFYTIVTPMLNPFIYTLRNkEVKHAL 313
gi 512818002 263 nllNFFIEETIAVFYTTVTPMLNPIIYSLRNkEVRTAL 300
gi 602667752 274 h-sKTTLDRIISVFYTVLTPLLNPLIYTLRNkEMKTAL 310

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