Conserved Protein Domain Family
7tmA_OR1_7-like

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cd15918: 7tmA_OR1_7-like 
olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320584
View PSSM: cd15918
Aligned: 37 rows
Threshold Bit Score: 403.148
Threshold Setting Gi: 440898862
Created: 12-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 14423777   25 AFLFGLFLSMYLVTVLGNLLIILATISDSHlhtpMYFFLSNLSFVDICFVSTTVPKMLVNIqthnKVITyagCITQMCFF 104
gi 47523970   22 QLFFSIFLALYLLGFLGNLLLLLAIGADVHlhtpMYFFLSQLSLVDLCFITTTAPKMLEALwtgdGSISfsgCLTQMCLF 101
gi 620956963  25 RLLFGLFLAVYSVSVLGNLLIILAVRSDPRlhtpMYFFLVHLSFVDICLTSTTVPRMLENLwaggKSIPfagCLAQMYFF 104
gi 395509597  53 ELLFPLFLVLYLAALLGNVLILVAVGSDSRlqtpMYVLLVNLSLADLCFTSATVPRLLYALltgdQTIThsaCLSQVFFF 132
gi 395508256  51 DFLFILFLVVYLAALLGNLLILMAVSSDSRlhtpMYILLINLSLGDLCFTSTTVPRLLYSLftgdQSINhtaCLTQVFFF 130
gi 38372651   25 TLLFSLFFCMYLVMVVGNLLIILAISIDSHlhtpMYFFLANLSLVDFCLATNTIPKMLVSLqtgsKAISypcCLIQMYFF 104
gi 283837936  25 QLLFSAFLSMYLLTGLGNLLIILAIAADPRlhtpMYFFLANLAFVDVCFTSTTIPKMLANHvsghKGISysgCLTQMFFF 104
gi 620972998  30 RLIFWLFLWMYLLGGAGNLLMILAVSSDPLlhtpMYFFLSNLSFVDLCLITTTVPKMLLNIqtqkKTISyagCLTQMYFF 109
gi 444524022  25 QVLFGLTFGLYLTGCLGNLLTILAVVSDPHlhspMYFFLSNLSLLDICFSSTTIPNMLVNHlcgrATISssaCLAQMYFF 104
gi 345326870  25 QLLFVSFLCMYLLGVLGNLLIVLAIGSDPHlhtpMYFLLSNLSAVDACFLSTTVPKMLCNIqthsRSVSfsgCLAQMYFF 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 14423777  105 LLFVgLDNFLLTVMAYDRFVAICHPlhYMVIMnPQLCGLLVLASWIMSVLNSMLQSLMvlpLPFCTHmEIPHFfCEINQV 184
gi 47523970  102 GVFAdMDNLLLAVMAIDRYAAICQPllYPLLMtPCRCGVLACGSWGIAHCASLVYTLLlsqLSFHSNqEIPHFfCDSRPL 181
gi 620956963 105 LSFVnTDGFLLAAMAYDRFLAICRPlrYAAAMgPRLCTLLVAGPWLVTHSNALVQTLMmarLSFCVGtVIPHFfCEFAPL 184
gi 395509597 133 LMAGnVDSYVLAAMAWDRYVAICKPlhYATVVtLPRCMVLLGAVWVGTALHSLLHTVLlarLTFCSNrVLPYFfCDLHPL 212
gi 395508256 131 LMAGnVSSYVLAVMAWDRYVAVCRPlhYATVVtRPRCIMLIGGVWVGTTLHSLLHTVLiarLTFCSSrDIPHFyCDVYPL 210
gi 38372651  105 HFFGiVDSVIIAMMAYDRFVAICHPlhYAKIMsLRLCRLLVGALWAFSCFISLTHILLmarLVFCGShEVPHYfCDLTPI 184
gi 283837936 105 IWFAgIDSFLLTAMAYDRFVAICHPlhYTTSItPRLCGFLVTASWASAFANALTHTVLltrLLFCGHnQVPHFfCDLSPL 184
gi 620972998 110 SLLLgMDNMILAVMAFDRNVAICHPlhYTSVMlPSLCGLLVAVPWVLTNLISLSLTLLtarLSFCGNnEIPHFfCDINGL 189
gi 444524022 105 IAFGgADSILLSAMAYDRYVAICRPlhYMTIMnALRCALLVAGTWISANLISTVHTVLvarLSFCTN-RIPHFfCDLNTL 183
gi 345326870 105 MLFViLDNFLLTGMAYDRFVAICHPlhYSAIMnPRVCALLVGVPWIVVSLISLLHTLLvfhLSFCSNnEIFHFfCEISHI 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 14423777  185 VHLACsdtflNDIVMYFAVALLGGGPLTGILYSYSKIVSSIraissaQGKYKAFSTCASHLSVVSLFYGTCLGVYLSSaa 264
gi 47523970  182 LWLSCsdthlNEFLMMVLSALLGISALLCIVSSYGCIFCAVarvpsaKGRRKALATCSSHLSVVLLFYSTVFATYLKPps 261
gi 620956963 185 LQLACsdthfNERLALAAAVLLGFTPAGCILASYARIVSVVlrvpsaRGKRRAFSTCGSHLVVVTLFYGTGIGVYLCPaa 264
gi 395509597 213 IHLACsdtslNYMMILVEGGSVVILPAICIVVSYVFIGAAVcqirapGGLRKAFSTCGSHLTVVILFYGTVVSVYLQPpg 292
gi 395508256 211 LQLACsdtslNYIIALVEGSTDIILPAACIVISYVFIGAAVngvratGGLHKALATCGSHLAVVMLFYGTLIIVYIQPlg 290
gi 38372651  185 LRLSCtdtsvNRIFILIVAGMVIATPFVCILASYARILVAImkvpsaGGRKKAFSTCSSHLSVVALFYGTTIGVYLCPss 264
gi 283837936 185 LKLACsdtslNDIMVYTVGALPIITPFVGILTSYTRIFTAVlripstGGKWKAFSTCGSHLSVVSLFYGTLIGVYFSPts 264
gi 620972998 190 LKLSCsdtrsAENLLLILTSVLGMPPLVGILASYSRIVATVlripsaKGKWKVFSTCGSHLTVVALFYGSGLAVFFTPps 269
gi 444524022 184 IKLSCsntqvNEMLVLILGSSVVLIPFTGIVASYTPIAAAVwdvpsaRGKWKAFSTCGSHLCVVSLFYGTIIGVYFNPas 263
gi 345326870 185 LKLSCsdtlpNEILLYFFVVVLAAVPFIGILVSYSRIISTIlkipsvGGRWKAFSTCGSHLSVVFLFYGTGLGVYFSPgs 264
                        250       260       270
                 ....*....|....*....|....*....|...
Feature 1              ## ###  #  ##              
gi 14423777  265 ---thNSHTGAAASVMYTVVTPMLNPFIYSLRN 294
gi 47523970  262 ---tsHSSGEVVAAVMYTLITPTLNPFIYSLRN 291
gi 620956963 265 ---ayPSGNGPMASLVYAVVTPTLNPFLYSLRN 294
gi 395509597 293 qmegqEEPQDLVAIVMFSVVSPTLNPYIYSLQN 325
gi 395508256 291 qtevqGKSGDLVASIMFSVVAPTLNPYIYGLQN 323
gi 38372651  265 ---vlTTVKEKASAVMYTAVTPMLNPFIYSLRN 294
gi 283837936 265 ---shTAQKDTAAAVMYTVVTPMMNPFIYTLRN 294
gi 620972998 270 ---shSKRKDTAASMMYTVVTPMFNPFIYSLRN 299
gi 444524022 264 ---thTTQRDMAATVMYTLVTPMLNPFIYSLRN 293
gi 345326870 265 ---sqGSRRGSTASVMYTVVTPMLNPFIYSLRN 294

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