Conserved Protein Domain Family
7tmA_OR1_7-like

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cd15918: 7tmA_OR1_7-like 
olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320584
Aligned: 37 rows
Threshold Bit Score: 403.148
Created: 12-Dec-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
O76100        25 AFLFGLFLSMYLVTVLGNLLIILATISDSHlhtpMYFFLSNLSFVDICFVSTTVPKMLVNIqthnKVITyagCITQMCFF 104 human
NP_999625     22 QLFFSIFLALYLLGFLGNLLLLLAIGADVHlhtpMYFFLSQLSLVDLCFITTTAPKMLEALwtgdGSISfsgCLTQMCLF 101 Norway rat
XP_007662264  25 RLLFGLFLAVYSVSVLGNLLIILAVRSDPRlhtpMYFFLVHLSFVDICLTSTTVPRMLENLwaggKSIPfagCLAQMYFF 104 platypus
XP_003759082  53 ELLFPLFLVLYLAALLGNVLILVAVGSDSRlqtpMYVLLVNLSLADLCFTSATVPRLLYALltgdQTIThsaCLSQVFFF 132 Tasmanian devil
XP_003758429  51 DFLFILFLVVYLAALLGNLLILMAVSSDSRlhtpMYILLINLSLGDLCFTSTTVPRLLYSLftgdQSINhtaCLTQVFFF 130 Tasmanian devil
Q8NGA1        25 TLLFSLFFCMYLVMVVGNLLIILAISIDSHlhtpMYFFLANLSLVDFCLATNTIPKMLVSLqtgsKAISypcCLIQMYFF 104 human
NP_666450     25 QLLFSAFLSMYLLTGLGNLLIILAIAADPRlhtpMYFFLANLAFVDVCFTSTTIPKMLANHvsghKGISysgCLTQMFFF 104 house mouse
XP_007663413  30 RLIFWLFLWMYLLGGAGNLLMILAVSSDPLlhtpMYFFLSNLSFVDLCLITTTVPKMLLNIqtqkKTISyagCLTQMYFF 109 platypus
ELV13677      25 QVLFGLTFGLYLTGCLGNLLTILAVVSDPHlhspMYFFLSNLSLLDICFSSTTIPNMLVNHlcgrATISssaCLAQMYFF 104 Chinese tree shrew
XP_001505998  25 QLLFVSFLCMYLLGVLGNLLIVLAIGSDPHlhtpMYFLLSNLSAVDACFLSTTVPKMLCNIqthsRSVSfsgCLAQMYFF 104 platypus
Feature 1        #  #                                            # #####                         
O76100       105 LLFVgLDNFLLTVMAYDRFVAICHPlhYMVIMnPQLCGLLVLASWIMSVLNSMLQSLMvlpLPFCTHmEIPHFfCEINQV 184 human
NP_999625    102 GVFAdMDNLLLAVMAIDRYAAICQPllYPLLMtPCRCGVLACGSWGIAHCASLVYTLLlsqLSFHSNqEIPHFfCDSRPL 181 Norway rat
XP_007662264 105 LSFVnTDGFLLAAMAYDRFLAICRPlrYAAAMgPRLCTLLVAGPWLVTHSNALVQTLMmarLSFCVGtVIPHFfCEFAPL 184 platypus
XP_003759082 133 LMAGnVDSYVLAAMAWDRYVAICKPlhYATVVtLPRCMVLLGAVWVGTALHSLLHTVLlarLTFCSNrVLPYFfCDLHPL 212 Tasmanian devil
XP_003758429 131 LMAGnVSSYVLAVMAWDRYVAVCRPlhYATVVtRPRCIMLIGGVWVGTTLHSLLHTVLiarLTFCSSrDIPHFyCDVYPL 210 Tasmanian devil
Q8NGA1       105 HFFGiVDSVIIAMMAYDRFVAICHPlhYAKIMsLRLCRLLVGALWAFSCFISLTHILLmarLVFCGShEVPHYfCDLTPI 184 human
NP_666450    105 IWFAgIDSFLLTAMAYDRFVAICHPlhYTTSItPRLCGFLVTASWASAFANALTHTVLltrLLFCGHnQVPHFfCDLSPL 184 house mouse
XP_007663413 110 SLLLgMDNMILAVMAFDRNVAICHPlhYTSVMlPSLCGLLVAVPWVLTNLISLSLTLLtarLSFCGNnEIPHFfCDINGL 189 platypus
ELV13677     105 IAFGgADSILLSAMAYDRYVAICRPlhYMTIMnALRCALLVAGTWISANLISTVHTVLvarLSFCTN-RIPHFfCDLNTL 183 Chinese tree shrew
XP_001505998 105 MLFViLDNFLLTGMAYDRFVAICHPlhYSAIMnPRVCALLVGVPWIVVSLISLLHTLLvfhLSFCSNnEIFHFfCEISHI 184 platypus
Feature 1                  #  ### ### ##                                            #  ## ##  #  
O76100       185 VHLACsdtflNDIVMYFAVALLGGGPLTGILYSYSKIVSSIraissaQGKYKAFSTCASHLSVVSLFYGTCLGVYLSSaa 264 human
NP_999625    182 LWLSCsdthlNEFLMMVLSALLGISALLCIVSSYGCIFCAVarvpsaKGRRKALATCSSHLSVVLLFYSTVFATYLKPps 261 Norway rat
XP_007662264 185 LQLACsdthfNERLALAAAVLLGFTPAGCILASYARIVSVVlrvpsaRGKRRAFSTCGSHLVVVTLFYGTGIGVYLCPaa 264 platypus
XP_003759082 213 IHLACsdtslNYMMILVEGGSVVILPAICIVVSYVFIGAAVcqirapGGLRKAFSTCGSHLTVVILFYGTVVSVYLQPpg 292 Tasmanian devil
XP_003758429 211 LQLACsdtslNYIIALVEGSTDIILPAACIVISYVFIGAAVngvratGGLHKALATCGSHLAVVMLFYGTLIIVYIQPlg 290 Tasmanian devil
Q8NGA1       185 LRLSCtdtsvNRIFILIVAGMVIATPFVCILASYARILVAImkvpsaGGRKKAFSTCSSHLSVVALFYGTTIGVYLCPss 264 human
NP_666450    185 LKLACsdtslNDIMVYTVGALPIITPFVGILTSYTRIFTAVlripstGGKWKAFSTCGSHLSVVSLFYGTLIGVYFSPts 264 house mouse
XP_007663413 190 LKLSCsdtrsAENLLLILTSVLGMPPLVGILASYSRIVATVlripsaKGKWKVFSTCGSHLTVVALFYGSGLAVFFTPps 269 platypus
ELV13677     184 IKLSCsntqvNEMLVLILGSSVVLIPFTGIVASYTPIAAAVwdvpsaRGKWKAFSTCGSHLCVVSLFYGTIIGVYFNPas 263 Chinese tree shrew
XP_001505998 185 LKLSCsdtlpNEILLYFFVVVLAAVPFIGILVSYSRIISTIlkipsvGGRWKAFSTCGSHLSVVFLFYGTGLGVYFSPgs 264 platypus
Feature 1              ## ###  #  ##              
O76100       265 ---thNSHTGAAASVMYTVVTPMLNPFIYSLRN 294 human
NP_999625    262 ---tsHSSGEVVAAVMYTLITPTLNPFIYSLRN 291 Norway rat
XP_007662264 265 ---ayPSGNGPMASLVYAVVTPTLNPFLYSLRN 294 platypus
XP_003759082 293 qmegqEEPQDLVAIVMFSVVSPTLNPYIYSLQN 325 Tasmanian devil
XP_003758429 291 qtevqGKSGDLVASIMFSVVAPTLNPYIYGLQN 323 Tasmanian devil
Q8NGA1       265 ---vlTTVKEKASAVMYTAVTPMLNPFIYSLRN 294 human
NP_666450    265 ---shTAQKDTAAAVMYTVVTPMMNPFIYTLRN 294 house mouse
XP_007663413 270 ---shSKRKDTAASMMYTVVTPMFNPFIYSLRN 299 platypus
ELV13677     264 ---thTTQRDMAATVMYTLVTPMLNPFIYSLRN 293 Chinese tree shrew
XP_001505998 265 ---sqGSRRGSTASVMYTVVTPMLNPFIYSLRN 294 platypus

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