Conserved Protein Domain Family
7tmA_GPR139

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cd15919: 7tmA_GPR139 
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.
Statistics
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PSSM-Id: 320585
View PSSM: cd15919
Aligned: 5 rows
Threshold Bit Score: 400.428
Threshold Setting Gi: 32165512
Created: 10-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of some class A family members with bound ligands (peptides or chemicals), agonists, or antagonists
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligand neurotensin, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ######
gi 74762300   27 FVPVVYYSLLLCLGLPANILTVIILSQLVARrqksSYNYLLALAAADILVLFFIVFVDFLLEDFilnmqmpqvpDKIIEV 106
gi 32165512   40 LPVIYYSALLCLGLPVANILTVIILSQLVMRrqksSYNYLLALAAADILVLLLIVFVDFILEDFilatplppslNSAVQV 119
gi 301605260  69 YVPVIYYSILLCLGLPANILTVIILSQLVARrqksSYNYLLALAAADIMVLFFIVFVDFLLEDFilnkqmpqmlDKIIEV 148
gi 513209588  25 YAPVVYYSLLLCLGLPANILTVIILSQLVARrqksSYNYLLALAAADILVLFFIVFVDFLMEDFilnkqmpqvlDKIIEV 104
gi 632952735  38 FVPVIYYSFLLCLGLPANILTVIILSRLVARrqksSYNYLLALAAADILVLFFIVFLDFVLEDFilsqqlpeilDKIIGI 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                       
gi 74762300  107 LEFSSIHTSIWITVPLTIDRYIAVCHPlkYHTVSyPARTRKVIVSVYITCFLTSIPYYWWPNIWted------------- 173
gi 32165512  120 LEFSSIHTSIWITVPLTIDRYIAVCHPlrYHTVSyPARTRKVIFVVYIGCLLSAAPYYWWPELWhslpgtgeggggaggg 199
gi 301605260 149 LEFSSIHTSIWITVPLTIDRYIAVCHPltYHTVSfPARTRKVIVSVYITCFLTSIPYYWWPNIWied------------- 215
gi 513209588 105 LEFSSIHTSIWITVPLTIDRYIAVCHPlkYHTVSyPARTRKVIVSVYITCFLTSIPYYWWPNIWied------------- 171
gi 632952735 118 LEFSSNHTSIWITVPLTIDRYIAVCHPlkYHTVSyPARTRRVIVCVYVTCFLTSIPYYWWPNIWsen------------- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  ### ### ##                                                 #  ## ##  # 
gi 74762300  174 yisTSVHHVLIWIHCFTVYLVPCSIFFILNSIIvyklrrk-snfrlrgYSTGKTTAILFTITSIFATLWAPRIIMILYHL 252
gi 32165512  200 nrrTVAQQILVWAHCITVYFLPCTVFFSLNAVIvhklrrrrscfrlrgYSTGKTTAILLAITSIFAVLWAPRTLVILYHF 279
gi 301605260 216 ytsTSVHHILIWIHCFTVYLVPCSIFFVLNSIIvyklqrk-snfrlrgYSTGKTTAILFSITSIFAILWAPRIIMILYHL 294
gi 513209588 172 yisTSMHHVLIWIHCFTVYLVPCSIFFILNSIIvyklrrk-snfrlrgYSTGKTTAILFTITSIFAILWAPRIIMILYHL 250
gi 632952735 185 ytsTSMHHVLIWVHCFTVYLVPCSIFFVLNSIIihklkrk-snfrmrgYSTGKTTAILLTITTIFAILWAPRMVMILYHL 263
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                     ## ###  #  ##                     
gi 74762300  253 Ygapiq---nrwlVHIMSDIANMLALLNTAINFFLYCFISKrFRTMA 296
gi 32165512  280 YspppasqgagrlLHILTDLANMLALLNTGVNFFLYCFISKrFRGMA 326
gi 301605260 295 Yvspih---nswlVHIVTDIANMLALLNTAINFFLYCFISKrFRTMA 338
gi 513209588 251 Yvspin---nswvVHIVSDIANMLALLNTAINFFLYCFISKrFRTMA 294
gi 632952735 264 Yvspin---nswlVHIVSDVANMLALLNTAINFFLYCFISKrFRTMA 307

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