Conserved Protein Domain Family
7tmA_GPR35_55-like

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cd15923: 7tmA_GPR35_55-like 
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophophatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.
Statistics
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PSSM-Id: 320589
View PSSM: cd15923
Aligned: 5 rows
Threshold Bit Score: 342.128
Threshold Setting Gi: 68068087
Created: 3-Nov-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   #  ##           #####
gi 71159390   21 TLQFAVHIPTFVLGLLLNLLAIHGFSTFLKnrwpdyaaTSIYMINLAVFDLLLVLSLPFKMVLSQvqsp--fpslCTLVE 98
gi 158253818  26 TLQKVTSIPMFVLGMLGNIYVLVKFCWRPKtqw---tyMNIYISNMVAADCALLIFLPVKIHYYNrelagglqklCNFVL 102
gi 68068087   21 LGFYAYLGVLLVLGLLLNSLALWVFCCRMQqw----teTRIYMTNLAVADLCLLCTLPFVLHSLRdtsd---tplCQLSQ 93
gi 557023967  15 LPLFIIYIPIFILGSLLNTLALWIFCWKLKkw----teSIIYMTNLIISDCCLLLFLPFKIYSFYqnwgl-gkelCFILY 89
gi 632934647  11 LFQYIIYIPTFIFGLLFNMIALWVICCKLQkw----teTTIYMTNLAVSDSLLLISLPFKMHSIRcpqaf-dlktCSFLT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # ##  #                                            # #####                      
gi 71159390   99 CLYFVSMYGSVFTICFISMDRFLAIRYPllVSHLRspRKIFGICCTIWVLVWTGSIPIYSfhgk------vekYMCFHnm 172
gi 158253818 103 SLYYINIYVSIFTITAISVVRYVAIKYPmkAREIFscRSALVVCAVIWVTICSISPVYFVtdss------ndkTMCFQrv 176
gi 68068087   94 GIYLTNRYMSISLVTAIAVDRYVAVRHPlrARGLRspRQAAAVCAVLWVLVIGSLVARWLlgi-------qegGFCFRst 166
gi 557023967  90 NIHYASMYTSIFIITAIAVDRYIAIRFPfrAKSWRspLKAAVVCGVMWITIVTLSIPGYLeahk-----kddsLHCFQkt 164
gi 632934647  86 ALYTINTYVSIYIVACISLDRYIAISHPfrATTLRstMKAVIICGTIWILVVLCCGLTFAledsvdnngtlnnPKCFRrs 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #  ### ### ##                                                 #  ## ##  #  
gi 71159390  173 sddtwSAKVFFPLEVFGFLLPMGIMGFCCSRSIHIllgrrd-htqdwVQQKACIYSIAASLAVFVVSFLPVHLGFFLQfl 251
gi 158253818 177 k-qtlSLHFILLLIIVGFVLPFIIMLYCSARVIHTlrkql--dvgsrSEKLQCMFIIMANLIVFIVCFFPVHLGYIVKyi 253
gi 68068087  167 ----rHNFNSMAFPLLGFYLPLAVVVFCSLKVVTAlaqrpptdvgqaEATRKAARMVWANLLVFVVCFLPLHVGLTVRla 242
gi 557023967 165 t--iePRKSLLVPVFFGFLTPLLLTTFCSVQVTCSlqkrnalnteeeKLLKQVKCVIIVNLLVFIICFLPLHVMFLVRyf 242
gi 632934647 166 ddvheEIYVFVFIETIGFIIPLTIVTFCSFRIIRTlqqrkr-wnprtAVTERTIRVVTANLITFIICFTPVHVGMFVKfm 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
Feature 1                           ## ###  #  ##                      
gi 71159390  252 vrnsfi-----vecrakqsISFFLQLSMCFSNVNCCLDVFCYYFVIk-eFRMNI 299
gi 158253818 254 vqkeytdpldnyscdskliAHNFLHSAFCLSDMNCGLDCFSYFFATktsWNMCC 307
gi 68068087  243 vgwna--------calletIRRALYITSKLSDANCCLDAICYYYMAk-eFQEAS 287
gi 557023967 243 adlsg-------dciymkhALFLTQVFNALANSNCCLDAFCYYFVAk-eCREAY 288
gi 632934647 245 kgt------------tnmnINLLFQFCVCIAATNCCFDGMFYYFATa-eIRELY 285

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