Conserved Protein Domain Family
7tmA_RNL3R1

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cd15926: 7tmA_RNL3R1 
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors
The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.
Statistics
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PSSM-Id: 320592
View PSSM: cd15926
Aligned: 5 rows
Threshold Bit Score: 511.748
Threshold Setting Gi: 20455271
Created: 9-Oct-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##            ###### 
gi 20455271   82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwrkssINLFVTNLALTDFQFVLTLPFWAVENaldfkWPFGkamCKIVSMV 161
gi 192452517  57 IIISIIYSVVCALGLIGNILVLYLMKSKQAwkkssINLFVTSLAVTDFQFVLTLPFWAVENamdftWLFGkamCKIVSYV 136
gi 556988607  53 IIISCVYSVVCALGLVGNLLVLYLMKTKQGwkkssINLFVTSLAVTDLQFVLTLPFWAVENaldftWLFGkamCKIVSYV 132
gi 449278255  11 IVISLVYSVVCAMGLVGNLLVLYLMKSKQGwrkssINLFVTSLAVTDFQFVLTLPFWAVENaldfnWLFGkamCKIVSYV 90
gi 301624673  68 IIISIVYSVVCALGLVGNVLVLYLMKTKQGwkkssINLFVTSLAITDFQFVLTLPFWAVENaldfsWLFGkamCKIVSYV 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                                           # #####         
gi 20455271  162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFsttvkv 241
gi 192452517 137 TATNMYASVFFLTAMSVARYCSVASALKSKRRRl---------------RFSAQWMTVIIWIAAVGAALPNAIFsttatv 201
gi 556988607 133 TAMNMYASVFFLTAMSVARYWSVASALRAKRRPi---------------GCSAKWMSSLIWVSAMLASLPNAIFsttstv 197
gi 449278255  91 TAMNMYASVFFLTAMSVARYRSVASALKNQRRGdpl-----------ggCCSAKWLCALIWLLAILASLPHAIFsttatv 159
gi 301624673 148 TAMNMYASVFFLTAMSVARYYSVASALKVKRRPa---------------GCSAKWVSVLIWVSAIVASLPNAIFsttatv 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #  ### ### ##                                             
gi 20455271  242 mgeELCLVRFPdkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVrfiadrraagtkggaavaggrptgasaRRL 321
gi 192452517 202 sneELCLVKFPdrs--gdaQFWLGLYHAQKVLLGFLIPFGIISICYLLLLrfitnkn--------------intssaKRR 265
gi 556988607 198 sneELCLVKFPdnr---naQFWLGLYHTQKVMLGFLIPLVIISVCYLLLLryitnkn--------------vtisntKRR 260
gi 449278255 160 fddVLCLVKFPegrg-snaQFWLGLYHIQKVLLGFVVPLAVISLCYLLLVrfisdkhvg----------stcsgpstKRR 228
gi 301624673 213 sseVLCLVKFPvnn--gnaQFWLGLYHAQKVLLGFLIPLFVITICYLLLVrfitdrn--------------isssstKRR 276
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                         #  ## ##  #                 ## ###  #  ##                     
gi 20455271  322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILikfnavpfsqeyflcQVYAFPVSVCLAHSNSCLNPVLYCLVRrEFRKAL 400
gi 192452517 266 SKVTRSVTIVVLSFFLCWLPNQALTAWGILiklnvvhfsyeyyttQVYIFPVTVCLAHSNSCLNPILYCLMRrEFRKAL 344
gi 556988607 261 SKVTKSVTIVVLSFFLCWLPNQAITAWGIMiklnvlhfsyeyyttQAYIFPITVCLAHSNSCLNPILYCLMRrEFRKAL 339
gi 449278255 229 SKVTKSVSIVVLSFFLCWLPNQALTTWGILiklnvvhfsteyflsQVYLFPISVCLAHSNSCLNPILYCLMRrEFRKAL 307
gi 301624673 277 SKVTKSVTIVVLSFFLCWLPNQALTTWGILiklnivqfsyeyfttQAYIFPITVCLAHSNSCLNPILYCLMRrEFRKAL 355

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