Conserved Protein Domain Family
7tmA_Bombesin_R-like

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cd15927: 7tmA_Bombesin_R-like 
bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors
This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.
Statistics
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PSSM-Id: 320593
View PSSM: cd15927
Aligned: 16 rows
Threshold Bit Score: 385.852
Threshold Setting Gi: 443696337
Created: 1-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 212286370  44 CVIPSLYLLIITVGLLGNIMLVKIFITNSAmrsvPNIFISNLAAGDLLLLLTcVPVDASRYffdeWMFGkvgCKLIPVIQ 123
gi 443696337  25 YIVPVVFSFIFLVGVVGNSLVIFIILRHRAmrttPNIFIGSLALGDLLLLLVsVPFYGMIYthydWPYGeflCKVKGFLL 104
gi 405978858  33 VVVPIIFAILLVVGVVGNGILIYTVFANKCmrntPNVLIVSLSIGDMVLLLMsAPFSSIHFshaeYPFGevvCRSNEYFQ 112
gi 443685813   5 YVVPVVFSLIFLVGVVGNSLVIFIILRNKAmrttPNIFIGSLALGDLLLLLVpVPFYGMIYtlpdWPHGeflCRLTGFLV 84
gi 197209894  28 YLVPILFAVIFVVGVLGNGTLVIVYARHRGmrnaPNTYIFSLALADLLVILIcVPFVSIIYtlesWPWGeliCRISESAK 107
gi 161077205  82 YIVPILFALIFVVGVLGNGTLIVVFLSVRQmrnvPNTYILSLALADLLVIITtVPLASTVYtveyWPYGsflCSLSEFMK 161
gi 281360191  70 YIVTVLYTLIFIVGVLGNGTLVIIFFRHRSmrniPNTYILSLALADLLVILVcVPVATIVYtqesWPFErnmCRISEFFK 149
gi 443685039   6 YLVPIIFAFIFIVGIVGNGTLILTVIKNKNmrniPNIFLVSLAMGDLLLILVsVPVSATFYifdeWKYGaamCKLNESLQ 85
gi 443687272  24 YVIPIAFAVIFFIGVIGNGVLILTVLFNKDmrtrPNIFIVSLAVGDLILLLVsIPFYGFTYmypkWQHGsfaCKLLAFLK 103
gi 232185     41 YVIPAVYGVIILIGLIGNITLIKIFCTVKSmrnvPNLFISSLALGDLLLLITcAPVDASRYladrWLFGrigCKLIPFIQ 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                                 # #####                    
gi 212286370 124 LTSVGVSVFTLTALSADRYRAIVNPmdmq-----tsgaLLRTCVKAMGIWVVSVLLAVPEavfsevari---ssldnssf 195
gi 443696337 105 TQSLGVSVFMLTVLAVNRYITTMIPnrq-------qqsPRRTLLTAAAVWILVSAVALWEgylrhvtth---ylpdrppl 174
gi 405978858 113 TLSVGVSVFTLTALSGDRFFAIVFPmskh-----kgkpKLKIAITVASIWIISALLAIPEainmkih--------eaegn 179
gi 443685813  85 TLSLGVSIFTLTALSADRYMAIMHPmkry-----tdspTIRTVVIAVVIWLVAAVFASVErslrniqih---qfdddasm 156
gi 197209894 108 DVSIGVSVFTLTALSAERYCAIVNPfrk-------lqlRKLPLVCATFIWGAAFIFAIPAaifsstvtv---elkdnvti 177
gi 161077205 162 DVSIGVSVFTLTALSGDRYFAIVDPlrkfhahgggrraTRMTLATAVSIWLLAILCGLPAligsnlkhl----gineksi 237
gi 281360191 150 DISIGVSVFTLTALSGERYCAIVNPlrk-------lqtKPLTVFTAVMIWILAILLGMPSvlfsdiksypvftatgnmti 222
gi 443685039  86 TLSLGISVFTLVALSGDRYMAIVHPmtrh-----rggsMWRTMGIAAMIWVVSAMLASLEavaahtf-------tanynl 153
gi 443687272 104 ALSLGVSIFTLTALSWDRYSACLHPirrh------kdtVPRTALIAAVIWIISTVLAAAEyaianvd-------ddsqpm 170
gi 232185    121 LTSVGVSVFTLTALSADRYKAIVRPmdiq-----ashaLMKICLKAAFIWIISMLLAIPEavfsdlhpfh--eestnqtf 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #  ### ### ##                                                   
gi 212286370 196 tACIpypqt---delhPKIHSVLIFLVYFLIPLAIISIYYYHiaktliksahnl-------pgeynehtkkqmETRKRLA 265
gi 443696337 175 rICHslvqstlerpsgPCVRVCIRFAVFFLIPLLIIGVLYALmarrlwsghldl--------qmqpfasqtsiESGRKIS 246
gi 405978858 180 qYCYidd------dnfAKIFTMVKFIVLFIVPLLIIGFFYCMmaailvtssrripce-tttgsvvsrqqqrqiEARVKVA 252
gi 443685813 157 rICNsyhee--wkvwfMCFRTSMRFVVYFVVPIVIIGVLYLLmarslwtsgsf---------sqqseaaarqiETRRKVA 225
gi 197209894 178 vYCTpypkd---wtnySKGMTIAKALVYYGLPLIVITVFYSLmarrllastremp------galqggqgeaqaKARKSVA 248
gi 161077205 238 vICYpypee--wginyAKSMVLLHFLVYYAIPLVVIAVFYVLialhlmysasv---------pgeiqgavrqvRARRKVA 306
gi 281360191 223 eVCSpfrd-----peyAKFMVAGKALVYYLLPLSIIGALYIMmakrlhmsarnmp------geqqsmqsrtqaRARLHVA 291
gi 443685039 154 qLCSpypss--wgkwyQKFHVIFRFLIYFAIPLLIIGSFYVSmarilvlsgkhipge-tpryggvrvaatkqtEARKKVA 230
gi 443687272 171 lVCNshpyh--fgywfPCFRAWLRFVIYFLIPIIAIAMLYTPmaktlwsnhtqiqqdaeadnvihgpaatrqtEARRKIA 248
gi 232185    194 iSCApyphs---nelhPKIHSMASFLVFYVIPLSIISVYYYFiaknliqsaynl-------pvegnihvkkqiESRKRLA 263
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                     #  ## ##  #             ## ###  #  ##                     
gi 212286370 266 KIVLVFVGCFIFCWFPNHILYMYRsfnyne-idpslgHMIVTLVARVLSFGNSCVNPFALYLLSesFRRHF 335
gi 443696337 247 IIVLSMAVIFTICWLPRHSYMIWFhcpshg--dynlfWHVLKITSYCLCFINSCVNPVLLYLISarFRRHF 315
gi 405978858 253 KVVLSFVLLFILCWLPRYVYLLWFhwadeg--emnhwWMILKVVAFCLMYIYSSINPYALYFLSsqFRRYY 321
gi 443685813 226 ILVLSIVVLFVICWLPRHIFMLWFfctsyg--synmfWHVLKIVSFCLSFMNSCVNPLALYLLSdqFRRHF 294
gi 197209894 249 CMVLIFVIVFFICFLPYHAFELWYhlsptslldyndwTHALRIIGFCLSFLNSCVNPVALYCVSgvFRQHF 319
gi 161077205 307 VTVLAFVVIFGICFLPYHVFFLWFyfwptaqddynafWHVLRIVAYCMSFANSCANPVALYFVSgaFRKHF 377
gi 281360191 292 RMVVAFVVVFFICFFPYHVFELWYhfyptaeedfdefWNVLRIVGFCTSFLNSCVNPVALYCVSgvFRQHF 362
gi 443685039 231 RLVLLFVVVFVVCWLPRHVYLFWYhfeing--tftifWHVFKIIGFCFSFINSCVNPLALYVLSdqFRRYY 299
gi 443687272 249 KLVLAIVILFMVCWLPRHIYLLWFhcpmpg--efnffWYIWKTVAYCLCFSNSCINPLALCILSdqYRRHF 317
gi 232185    264 KTVLVFVGLFAFCWLPNHVIYLYRsyhyse-vdtsmlHFVTSICARLLAFTNSCVNPFALYLLSksFRKQF 333

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