Conserved Protein Domain Family
7tmB2_GPR133-like_Adhesion_V

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cd15933: 7tmB2_GPR133-like_Adhesion_V 
orphan GPR133 and related proteins, group V adhesion GPCRs, member of class B2 family of seven-transmembrane G protein-coupled receptors
group V adhesion GPCRs include orphan receptors GPR133, GPR144, and closely related proteins. The function of GPR144 has not yet been characterized, whereas GPR133 is highly expressed in the pituitary gland and is coupled to the G(s) protein, leading to activation of adenylate cyclase pathway. Moreover, genetic variations in the GPR133 have been reported to be associated with adult height and heart rate. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.
Statistics
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PSSM-Id: 320599
View PSSM: cd15933
Aligned: 11 rows
Threshold Bit Score: 332.37
Threshold Setting Gi: 156229222
Created: 5-Feb-2015
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative polypeptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on mutagenesis of human glucagon receptor (GCGR), and modeling studies of GCGR and other related class B GPCRs
  • Comment:Residues in the globular N-terminal extracellular domain and the extracellular loops of the 7TM domain may also be involved in ligand binding.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #   #                                            #  ##  #        #      #
gi 59797942  655 ESLLRTLSFVGCGVSFCALTTTFLLFLVAGVpks---erTTVHKNLTFSLASAEGFLMTSEWAKane--vaCVAVTVAMH 729
gi 190583729 357 SKILGTIGIAGVVTSAVFLLFTLIILVSLRNlrs---drFFIHKNLCLALLLANVSAVITSQAYlhh--taCKVSAIIQH 431
gi 190579573 506 LAPIIIIEYIGIGFSTICIALALIVFGVLRLks----drFIIHRNLLVALFLLQCTIIAGSQSEgnk--nlCTAMAILTH 579
gi 405972714 600 ERVLYIMTTLGCSISIACLALTLIIYVYLRVlsn---dtVMIHANLSVALLLGQLVLVTSDGAAkym--aaCKIVTALIH 674
gi 59797935  563 QVALSSISYVGCSLSVLCLVATLVTFAVLSSvstirnqrYHIHANLSFAVLVAQVLLLISFRLEpgt--tpCQVMAVLLH 640
gi 156229222  42 TRALSIVTYIGCTLSILGVFLTVVTLISLPVlrs---erTRIHCNLCIAVGVSQILFLAGGTEElveskvgCKLYAALMF 118
gi 156211341 567 ERALEIITYVGCSISLVCLAITIISMPFLRLtst---lrYKIHMQLCISLAVSQAAFLLGIAAIryk--vaCMITAMSLH 641
gi 190579567 505 LQEINLVAYIGLGISIASIVLTLLIFTLLRLns----grFTIHKNLLLAILLSQICLVASPNANinp--ifCKIAAICLH 578
gi 556098607 641 KMALETITFIGCALSIMGGILTVLTFLFLRIyt----nrVMIHMNLAVAIIGAQILMLIEEAIArgt--aaCTAVTLLLY 714
gi 156221951 439 RIALSSISYIGLILSLLGEAITVAAYLSFLNvrk---drIQIRLNLIVNLMLAQIVLIAGLNVTghk--tlCLVVVALVQ 513
gi 190586098 517 QVILDLLSYVCCGISIASLIVSMMIFSLIQIss----drFQIHTNLAFTMLISQIGILLGGWDFvkqnpviCKVVAIGLH 592
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     ## 
gi 59797942  730 FLFLVAFSWMLVEGLLLWRKVVavsmhpgPGMRLYHATGWGVPVGIVAVTLAMLphdyv------apghCWLnvHTNAIW 803
gi 190583729 432 FLFTAAFTWMLVEGLHLYLLMVkvftsgrSKTFLYVFVGWGIPVIIVATSIAIRfndyg------snriCWLsiKNGLIW 505
gi 190579573 580 FFCVATFSWMLIEAIHLYFLIItvf--kkSRISIYYFIGWGLPIITVAVTLTAKfdgyvnnngvsslnkCWLntQDGFKW 657
gi 405972714 675 FLFMSAFAWMMVEGLALYLSCTrpisaygDMRMIYVLIGWGLPAIIVLITLGSNfqdyge----geyssCWLsiDDGLIW 750
gi 59797935  641 YFFLSAFAWMLVEGLHLYSMVIkvfgsedSKHRYYYGMGWGFPLLICIISLSFAmdsyg------tsnnCWLslASGAIW 714
gi 156229222 119 YAFMSVFSWMLVEGIHLYQMIIiaf-itrAMMKFYYFIGWGLPMCIVVIASCIShkgyg------tpnfCWLslTDHTIW 191
gi 156211341 642 YFYTAAFSWMFLEGFHLYMKIViayekkaIKQLYYFCFGWGFPFIIVGISSAVNsegyg------teagCWLslERGFRW 715
gi 190579567 579 FFCFASFSWMLVEGVHLYFMIIavf-nqkTRSHYYYIVGWGMPLVVVGFSVLIRfdgyg------gderCWLstKDGLIW 651
gi 556098607 715 YFNMSIFSWMLVEGIQLFLQIVvvf-tsdSKMKIFYGIGWGAPILLATICLAVLnsdlg------qhgvCWLspHDNSIW 787
gi 156221951 514 FTYTASFCWMLVEGCYLYRVIVkvf-nyhIDLRYCYAISYGFPTLMVVAALLYAylltgeiqgyvstnvCWMnyDNHVIW 592
gi 190586098 593 YFLLAMFSWMLMEALHLYFQIIsvf-ntkSRLKLYYILGWGAPAVIVGTAVGLGhkyyg------lnqiCWLslNNGMIW 665
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # #                                                               #  #          
gi 59797942  804 AFVGPVLFVLTANTCILARVVMITVSSARrrarmlspqpclqqqiwtqIWATVKPVLVLLPVLGLTWLAGILVHLs--PA 881
gi 190583729 506 AFVGPVIAIITINFVIFILVARIICRSSSpvaieqk------tadfatIKSTLRGAVILVPILGLTWIFGVLTINeqtLF 579
gi 190579573 658 AIMGPVISIIVVNAVVMICVVKITVSSSIadayksdn----rkgrlqgIKSMIKASAILTPILGLTWLLALIPITrqtIV 733
gi 405972714 751 SFMAPMIIIVVMNILVLGLVLKAFLTLRTnskkt----------eaarLFASFKVMVTLLPILGITWLLGILVPVs--DV 818
gi 59797935  715 AFVAPALFVIVVNIGILIAVTRVISQISAdnykih--------gdpsaFKLTAKAVAVLLPILGTSWVFGVLAVNgcaVV 786
gi 156229222 192 AFTGPAIVVILVNAVVLGAVLRLRTKLENnaevshr-----aclsilfLRTGARVSIMLLPLLGLSWIFGLFTAMegtLV 266
gi 156211341 716 VFIGPVLIILAINLCIMIKVLHIMMVLQNdplkk---------kknsrLSSLAKGLAVLLPLLGLTWLFGVLCVNsqtIV 786
gi 190579567 652 AFVGPVIAIISINTIIMVAVIKITVTSTTvlvyqkn------ienfagIKSMVKATAILCPLLGLTWILGMIPISgatIV 725
gi 556098607 788 AFAVPALAVIFTNLVILVIVMKVVYSMSNtmdkp----------klavIRNAVKASVLLLPLLGCTWLFGVLAVSsetVI 857
gi 156221951 593 MFAGPVIFIATVNMLVLGCVVKEMILLPTvdpens--------rtsenIRSSARAIVVLTPLLGITWLFGLLSLSgigVV 664
gi 190586098 666 AFTGPALFVIAVNFVVMVLIIKVTFNKAKihqndt-------gstkkqAKTISKALLILLPILGLTWIFGILSTNdqsII 738
                        250       260       270
                 ....*....|....*....|....*....|..
Feature 1         #   #                          
gi 59797942  882 WAYAAVGLNSIQGLYIFLVYAACNe-EVRSAL 912
gi 190583729 580 FDYIFVITNSLQGFFIFLFHCALNs-EVQNAL 610
gi 190579573 734 FAYLSVILNSCQGITIFVFHCILNs-EVRLKY 764
gi 405972714 819 FHYLFIIGTSMQVRKKYNERRRRNtcSTSDFW 850
gi 59797935  787 FQYMFATLNSLQGLFIFLFHCLLNs-EVRAAF 817
gi 156229222 267 IQYIFAATNSLQGLMIFAFHCVGNs-EVGCLL 297
gi 156211341 787 FQYIFAVLNSLQGAFIFLLNYAGNr-EVRSSF 817
gi 190579567 726 MSYVYVILNSTQGLSIFVFHCLFNs-EVRQAY 756
gi 556098607 858 FQYLFTVTNTLQGFMLFFCHCVWNt-EVRESF 888
gi 156221951 665 GDYIFTILNSSQGFMIFIFHCVRNs-ELKAAF 695
gi 190586098 739 FSYIFVILNGLQVRILLKRKLGLTs-KLSKGK 769

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