Conserved Protein Domain Family
7tmA_OR4Q3-like

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cd15935: 7tmA_OR4Q3-like 
olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320601
View PSSM: cd15935
Aligned: 6 rows
Threshold Bit Score: 415.702
Threshold Setting Gi: 641788036
Created: 12-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##           ###### 
gi 38372800   25 LFLFLLFLFFYIAIVLGNLLIVVTVQAHAHLlqsPMYYFLGHLSFIDLCLSCVTVPKMLGDFLqqGKSISFsGCLAQIYF 104
gi 637325791  22 TYLSTLVLACYAVTLLGNCLILATVLSEPHLrnsPMYFFLANLSLTDMTFASVAAPKFAADLLkcGHSISYaGCMGQLFY 101
gi 641788036  22 LLLFGLVLACYAASLLGNFLIVVTVRVDPRLlqsPMYFFLANLSLIDMALGSVAAPRMLGNLLseGSTISYgGCMAQLFF 101
gi 602643254  26 LLLFVLALAAYTTCLMGNLFIVVTVHGEPHLyqsPMYFFLANLSMFDIFLSSLATPKLLTDLVtcSRTISFmGCMIQIFF 105
gi 602643256  37 LLLFVLVMMCYAAILLGNLLIVLTVHIDSHVqklPMYFFLANLSIIDTSVGSVIVPKVAADLVtcGRAISFgGCMSQLFF 116
gi 345312028  42 LLLSCLFSAAFAAIVLGNLLIVVSVRADRRLlqaPMYLFLAHLAFLDLGLGCVTVPKVLEDLLrgRNTISFpACLAQVCA 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                            # #####                        
gi 38372800  105 LHFLGASEMFLLTVMAYDRYVAICNPLrYLTVMnPQLCLWLVLACWCGGFIHSIMQVILViqLPFCGPNELDNFYCDVPQ 184
gi 637325791 102 LHLFGGAEMLLLSVMAYDRYVAICHPLrYGAIMdRQYCFKMLAVCWTGGFLHSTIHAAVLahLPFCGPNVLDNFYCELPE 181
gi 641788036 102 LHFLGGSEMFLLTLMAYDRYVAICHPLsYTETMhRHRCLGLLATCWAGGLLHSATQLVLVvrLPFCGPSKLDNFYCDVPQ 181
gi 602643254 106 IHFIGGSEMLLVTLMAYDRYMAICHPLtYMASMnRPCCIKLLTSCWAGGLIHTTTQMVLLlrLPFCGPNTLDNFHCDLPQ 185
gi 602643256 117 LHFFGGSEMLLLTLMAYDRYVAICHPLtYTTTMnRPRCIRLLCFCWTGGLLHSASQLFLVlrLPFCGPNEVDNFFCDVPQ 196
gi 345312028 122 LHLLGASEMLLLTAMAFDRYVAICRPLrYLAVMdGRLRRRLVTACWAGGFVHSATQAALVlrLPFCGPNRLDNFYCDVPQ 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                            #  ## ##  # 
gi 38372800  185 VIKLACmdtyvVEVLVIANSGLLSLVCFLVLLFSYAIILITLrth-fcQGQNKVFSTCASHLTVVSLIFVPCVFIYLRPf 263
gi 637325791 182 VLKLACmdiyaSEVITIVNSGLITLPCFLTLLISYSMILTTVcsr-fgKGGAKALSTCGSHLMVVSLFYVPCIIVYLKPf 260
gi 641788036 182 VVKLACtdtymVEMLMVSNSGLISLVCFLVLLGSYGVILVTLrgrfgdGGGGKALSTCSAHLMVVSLIFVPCIFVYLRPf 261
gi 602643254 186 VIKLACvdtyiTELLVVANSGLLSLVCFLALLVSYGIIVGSLqgh-frESGGKALATCSSHLIVVFISFVPCIFVYLVPf 264
gi 602643256 197 VVKLACvdshvTEILMVANSGLLSLVCFVILLVSYGIILSTLqgr-frESRGKALYTCSSHLTVVSLFFLPCLFVYLVPi 275
gi 345312028 202 LTKLACadtavVEALMVANSGLLSLACFVVLLASYTVILATLrs---rLRHGRGLATCASHLTVVSLIFGPCVFIYLRPf 278
                        250       260
                 ....*....|....*....|....*....
Feature 1          ## ###  #  ##              
gi 38372800  264 cSFSVDKIFSLFYTVITPMLNPLIYTLRN 292
gi 637325791 261 sNSQKNKVVSTFYMLATPALNPFIYTLRN 289
gi 641788036 262 sSSRMDKMASIFYTIITPVLNPIIYTLRN 290
gi 602643254 265 sRSHMDKVASVFYTLIVPSLNPIIYTLRN 293
gi 602643256 276 fSSSLDKVASVFYTTITPFLNPMIYSLRN 304
gi 345312028 279 rSFPVDKVISVFYTVVTPGLNPLVYTLRN 307

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