Conserved Protein Domain Family
7tmA_OR4Q2-like

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cd15938: 7tmA_OR4Q2-like 
olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320604
View PSSM: cd15938
Aligned: 3 rows
Threshold Bit Score: 442.774
Threshold Setting Gi: 449270718
Created: 12-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##           ###### 
gi 166215772  25 AGLFVLFLFFYMSIWVGNVLIMVTVASDKYLnssPMYFLLGNLSFLDLCYSTVTTPKLLADFFnhEKLISYdQCIVQLFF 104
gi 558185926  27 AALFSVFLLVYIATLVGNSLIMATVSSDPHLr-tPMYFLLGNLSFLDLCYSTVTAPKMLLDFLseRRSISYpACMAQLFF 105
gi 449270718  32 VLFFALFFLAYTMVLLGNLLIIVTVRTNPKLs-sPMYFLLCNLSFIDICCISVTCPRMLVDLLsqRKAIAFeACIAQLFF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##  #                                            # #####                        
gi 166215772 105 LHFVGAAEMFLLTVMAYDRYVAICRPLhYTTVMsRGLCCVLVAASWMGGFVHSTVQTILTvhLPFCGPNQVENFFCDVPP 184
gi 558185926 106 LHFVGAAEMFLLTVMAYDRYVAICKPLhYPSIMnRTLCSWLVAASWAGGFIHSLVQTVLTmrLPFCGPNQVDNFFCDVPP 185
gi 449270718 111 LHFAGASEMFLLTVMAYDRYTAICKPLhYTTIMsRRVCWVLVSACWAGGFLHSIVQTLLTiqLPFCGPNTINNFFCDVPP 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                           #  ## ##  #  
gi 166215772 185 VIKLACadtfvIELLMVSNSGLISTISFVVLISSYTTILVKIrs--kEGRRKALSTCASHLMVVTLFFGPCIFIYARPfs 262
gi 558185926 186 VIKLACtdtyvVELLMVSNSGLISTSCFVVLVASYATILVRIrs--pEGRRKALSTCASHLTVVTLFFGPCIFIYARPfs 263
gi 449270718 191 VIRLACtdicvTEWLMASNSGLISLVCFLVLVTSYTFILVTIrvrftEEHWKALSTCASHVMVVTIFFVPCIFIYLRPfs 270
                        250       260
                 ....*....|....*....|....*...
Feature 1         ## ###  #  ##              
gi 166215772 263 TFSVDKMVSVLYNVITPMLNPLIYTLRN 290
gi 558185926 264 IFPVDKLVSVLYNIITPTLNPMIYTLRN 291
gi 449270718 271 TFPSDKHICVIYTVLSPMLNPLIYTLRN 298

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