Conserved Protein Domain Family
7tmA_OR4E-like

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cd15940: 7tmA_OR4E-like 
olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320606
View PSSM: cd15940
Aligned: 6 rows
Threshold Bit Score: 422.235
Threshold Setting Gi: 301621270
Created: 12-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 166215771  29 IAMFSMFLIFYVLTLIGNVLIVITIIYDHRLhtPMYFFLSNLSFIDVCHSTVTVPKMLRDVWseEKLISFdACVTQMFFL 108
gi 530653326  28 LILFMVFLPTYLLTLAGNILIMVTIVHDRRLhtPMYFFLSNLSFIDVCHASVTVPKMLSDFLsaEKTISFgGCVVQMFFL 107
gi 558190532  25 LALFALFSVAYLLILVGNGLIMVTVASDRHLhiPMYFFLGNLSFIDICHASVTAPKMLTDLLsgEKTISFgGCVAQLFFL 104
gi 38372663   25 MLFFMAFSAIYMLTLSGNILIIIATVFTPSLhtPMYFFLSNLSFIDICHSSVTVPKMLEGLLleRKTISFdNCITQLFFL 104
gi 301621268  23 YCMFFIFLILYVLLLSGNILIMMTIRADPHLhcPMYFFLAKLSFIDLCYSSVTVPKMLADLLsdRKTISFnGCITQLYFF 102
gi 301621270  25 VSFFVLFLVLYLITLSGNTLIMASVYMDSRLqsPMYFFLGNLSVLDICYSTVTIPKMLSNVItnSKTITFnQCMSQLFFL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 166215771 109 HLFACTEIFLLTVMAYDRYVAICKPLqYMIVMnWKVCVLLAVALWTGGTIHSIALTSLTikLPYCGPDEIDNFFCDVPQV 188
gi 530653326 108 HLFTCTEIFLLTVMAYDRYVAICNPMhYLTVMnHKVCLLLAGAVWLGGTVHSLALTGMTikLPYCGPREIDNFFCDVPPV 187
gi 558190532 105 HLCACAEIFLLTIMAYDRYMAICHPLqYPTLMsLPACTWLVGALWSGATVHSLVQTGLTvrLPYCGPNVIDSYFCDVPPV 184
gi 38372663  105 HLFACAEIFLLIIVAYDRYVAICTPLhYPNVMnMRVCIQLVFALWLGGTVHSLGQTFLTirLPYCGPNIIDSYFCDVPLV 184
gi 301621268 103 HFFACAECFLFTAMGYDRYVAICKPLhYSTIMnRKLCLWMVAATWTIGFVHSNIQTSLTmgLPFCGPNEIDSFFCDIPPL 182
gi 301621270 105 HMFGGTECFLLTLMAYDRYVAICNPLrYHTIInHTFCLGMVASTWLAGFLHSFTQAFLTyqLHFCGPNTINHFFCDVHPL 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                            #  ## ##  # 
gi 166215771 189 IKLACidtpyvLEILIVSNSGLISVVCFVVLVVSYAVILVSLrqq-isKGKWKALSTCAAHLTVVTLFLGHCIFIYSRPs 267
gi 530653326 188 IRLACtnt-yiIEVLIISNSGLISVVCFVVLVGSYGVILVSLrtr-fsEGRRKALSTCAAHLTVVTLFLGHCIFIYSRPs 265
gi 558190532 185 IKLACtdt-ylTGVLIVSNSGLISLTCFLALLGSYLVILVSLrsr-stEGRRKALSTCASHLAVVALFFGPCIFIYTRPa 262
gi 38372663  185 IKLACtdt-ylTGILIVTNSGTISLSCFLAVVTSYMVILVSLrkh-saEGRQKALSTCSAHFMVVALFFGPCIFIYTRPd 262
gi 301621268 183 IRLACsdt-kmIDAMIVANSGFVSLGCFLAVLFSYIGIGSTIlkirsaEGRRKAFSTCVSHLTVVTFFFGPCVFIYMRPs 261
gi 301621270 185 AVLACsdt-sfIDMFIIANSGMISLVCFVILLMSYIGIISTVlkmqstERRFKAFSTCASHLMVVTLFFGPCIYIYLRPp 263
                        250       260
                 ....*....|....*....|....*....
Feature 1          ## ###  #  ##              
gi 166215771 268 tSLPEDKAVSVFFTAVTPLLNPIIYTLRN 296
gi 530653326 266 tSFSEDKVVSVFFTAITPLLNPIIYTLRN 294
gi 558190532 263 tSFSLDKVVSVFYTVVTPVLNPAIYTLRN 291
gi 38372663  263 tSFSIDKVVSVFYTVVTPLLNPFIYTLRN 291
gi 301621268 262 tALKVDRVVTVFYTVIAPMLNPVIYTLRN 290
gi 301621270 264 iNYSADKLISVLYTVLTPLLNPIIYTFRN 292

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