Conserved Protein Domain Family
7tmA_OR10S1-like

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cd15941: 7tmA_OR10S1-like 
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320607
View PSSM: cd15941
Aligned: 3 rows
Threshold Bit Score: 462.396
Threshold Setting Gi: 223590111
Created: 12-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #  ##            ######
gi 223590111  38 SLFFLLFLLIYSITVAGNLLILLTVGSDSHLs-LPMYHFLGHLSFLDACLSTVTVPKVMAGLLtldGKVISFeGCAVQLY 116
gi 557324103  29 LLFLLLFLLIYLLTLLGNLVILVAILCDPRLhtLPMYIFLAHLSILDSCLSSVTAPKVLAGLVspsGRTISFaGCVVQLY 108
gi 602667746  25 FLFFLIFTTIYLLTVLGNLLILFTIMAEPQLhgLPMYFFLCNLSLLDTCLSSVTVPKILASFIassYRTISFrGCVLQLY 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                                            # #####                       
gi 223590111 117 CFHFLASTECFLYTVMAYDRYLAICQPlhYPVAMnRRMCAEMAGITWAIGATHAAIHTSLtFRLLYCGPCHIAYFfCDIP 196
gi 557324103 109 AFHFLASTECFLYTVMAYDRYQAVCHPlhYITVMgRRVCMGLAAGTWLTGCIHGAIHTCLtFRLPYCGPHQIDYFfCDIP 188
gi 602667746 105 AFHFLASTECFLYTVMAYDRYLAICHPlnYTTLMnRRISLGLVGGTWFTGSFHAAIHASLtFCLPYCGPNQVNYFfCDIP 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #  ### ### ##                                            #  ## ##  #
gi 223590111 197 PVLKLACTDttiNELVMLASIGIVAAGCLILIVISYIFIVAAVLRIrTAQGRQRAFSPCTAQLTGVLLYYVPPVCIYLQP 276
gi 557324103 189 PVLKLACADtvaDRTLILANIGAVIAACFLXIGISYAYIVAAVLRIrTAEGRRRAFSTCSAHLTLVILFYGSSAFIYLRP 268
gi 602667746 185 PVLKLACADttvNHAMIRINIALVGTGCFLLICISYTYIASAILKIqTTEGRHRAFSTCSAHLTVVLLYYSPSIFIYMCP 264
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1           ## ###  #  ##                     
gi 223590111 277 rSSEAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKHAL 313
gi 557324103 269 sSNQASDGVVAMFYTVVTPMLNPFIYSLRNKEMMRAL 305
gi 602667746 265 sSSQATYGILAVFYAIITPMLNPFIYTLRNKEVKRAL 301

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