Conserved Protein Domain Family
7tmA_OR10G6-like

?
cd15942: 7tmA_OR10G6-like 
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
?
PSSM-Id: 320608
View PSSM: cd15942
Aligned: 6 rows
Threshold Bit Score: 446.109
Threshold Setting Gi: 602676461
Created: 12-Dec-2014
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 74760323   46 APLFLAFLVIYLLTVSGNGLIILTVLVDIRlhrpMCLFLCHLSFLDMTISCAIVPKMLAGFllgSRIISFggCVIQLFSF 125
gi 602676453  25 APLFLFFVCVYLLTLLSNFLVFLATIYEPQlhkpMYWFLCHLAIADIATSTTVVPKMIASFlqgNKVISFagCITQLFVY 104
gi 602667754  25 IPLLFFFSIMFILTLSGNSLIILVVISDLQlhkpMYWFLCHLSILDMAFSAVVVPKVIAGFipgGKVISFvgCVTQLFFF 104
gi 602676461  25 TPLFLFFLLVYFLSITGNILILLTVASKSDlhkpMYWFLCNLAIMDIAVSTVVVPKVMDGFvegGRIISFggCLTQLFFY 104
gi 530651320  25 IPLFLFFLIIYLLTLYGNLLILLVVARERRlhkpMYWFLCHLSFLDMTVSSVVVPKVVAGFlsgGRAISFqgCVAQLFFF 104
gi 602667756  25 LPLLLFFSVMFALTLAGNSLIILVVISDLQlhkpMYWFLCHLSLLDMAFSSVVVPKVIAGFnsrGKIISFteCVTQIFFL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 74760323  126 HFLGCTECFLYTLMAYDRFLAICKPlhYATIMtHRVCNSLALGTWLGGTIHSLFQTSFvFRLPFCGPNRVDYIfCDIPAM 205
gi 602676453 105 HFVGCAECFLYTVMAYDRFLAICWPlhYSILMnHKICLWLSVGTWFGGCLHSAIETALtFHLPYGPGNEVSYIfCDIPAM 184
gi 602667754 105 HFLGCAESLLYTLMAYDRFLAICKPlhYGNIMnWKACLSLSLGTIIGGCLQSTFQTFLtFHLPYGQKNNIDYVfCDIPAM 184
gi 602676461 105 HFLSCSEFFLYTVMAYDRFLAICKPlhYNTIMnHRMCFCLSLGTWLGGCLHSIMVTSLsYGLPYGPKNEVNFIlCEILSV 184
gi 530651320 105 HFLGCTECFLYTVMGYDRFLAICKPlhYSIIMnHRACLCLAVVTWLAGSLHSTIQTALtFQLPYGQENRVRYIfCDIPAV 184
gi 602667756 105 NFLGCAESLLYTLMAYDRFLAICKPlhYGNIMsWKACLILSLGTIIGGCLNSTFQTTFtFRLPYGQRNSIDYVfCDIPAI 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 74760323  206 LRLACADtaiNELVTFADIGFLALTCFMLILTSYGYIVAAILripsaDGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPcs 285
gi 602676453 185 LKLACVDtsfNEMFTLIDVGLVAMSCVLLILVSYVYIIFAILkirngDGQRHAFSTCTSHIILVITFYIPLTFTYLRPga 264
gi 602667754 185 LKLACVDtkfNELVSFIDVGLVAMTCFLLILASYVYIIIAILrisssEGQRRAFSTCTAHITVVVIYYLPVVYHYMRPss 264
gi 602676461 185 LKLACSDtwfQEIFTLVDIGLVAIFCIFFIVMSYMYIVSAILkipsvEGQHRAFSTCTSHLIVVMICYVPAAFNYLRTgt 264
gi 530651320 185 LKLACRDtalNELVTFVDIGFLAFTCFLLILMSYVYIVSAILrihsaKGRRRAFSTCMAHVTMVVTYYVPEFFIYLRPgs 264
gi 602667756 185 LKLACADtelNELMIFIDIGLVAMTCFLLILASYAYIVIAILkisssEGRHRAFSTCSAHLTVVVIYYLPLFYRYMRPss 264
                        250       260       270
                 ....*....|....*....|....*....|....*
Feature 1         ## ###  #  ##                     
gi 74760323  286 QEPLDGVVAVFYTVITPLLNSIIYTLCNkEMKAAL 320
gi 602676453 265 EDPLGGVVAIFYTTVTPLLNPVIYTLRNkEMKYAV 299
gi 602667754 265 QDSMDGVVSVFYTTVTPLLNPVIYTLRNkEMKNAL 299
gi 602676461 265 LDLLSGVIALFYTTWTPFLNPLIYTLRNkEMKDAM 299
gi 530651320 265 WHPLDGVVAVFYTTVTPLLNPLIYTLRNkEMKDAL 299
gi 602667756 265 QDSMDGVVSMFYTTITPLLNPVIYTLRNkEMKTAL 299

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap