Conserved Protein Domain Family
7tmA_OR2B-like

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cd15947: 7tmA_OR2B-like 
olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320613
View PSSM: cd15947
Aligned: 28 rows
Threshold Bit Score: 398.15
Threshold Setting Gi: 512957874
Created: 16-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 14423800   25 IPPFVMFLFSYILTIFGNLTIILVSHVDFKlhtpMYFFLSNLSLLDLCYTTSTVPQMLVNIcntrKVISYggCVAQLFIF 104
gi 311033421  25 MIFFIAILFSYLLTLLGNSTIILLSRLEARlhtpMYFFLSNLSSLDLAFATSSVPQMLINLwgpgKTISYggCITQLYVF 104
gi 33238954   27 LPLFFVLLTSYMFTLLGNIAIILVSQLDSQlqspMYFFLTSLSFLDLCFTTTTVPQMLFNLqgpnKNITYigCMAQAYVF 106
gi 351711645 305 RPLFGMVLLSYVLTLVGNSSIILLSLLDPRlqmpMYFFLDNLSLLDIGVTCTIVPQLLTNLwgqdKTIASwgCITQVYFF 384
gi 47576593   25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQldspMYFFLSNLSFLDLCFTTTTIPQLLRNLwgpdKSISYrgCVTQFYIF 104
gi 74762190   29 LPLFVVLLLSYVLAMLGNVAIILASRVDPQlhspMYIFLSHLSFLDLCYTTTTVPQMLVNMgssqKTISYggCTVQYAVF 108
gi 47576611   25 LPLFIILLVTYPTAMIGNIAIILVSTIDPSlhspMYFFLTNLSFLDMCYTTSIVPQMLINLggstKTISYmrCAIQLYFY 104
gi 47575909   29 MPLFGVLLVSYIFTMIGNSSIIILSLLEPRlqtpMYFFLDNLSMLDLCATCTIVPQLLVNLwgpeKTIASwsCITQSYLF 108
gi 512957874  65 RPLFAVVLISYFLNLVGNSSIILLSLEDPRlq-tPMYFLDNPSLLDLSVTCGTVPQMLAKLwgphKTIAAwaCITQGYIL 143
gi 440905600  28 MVLFWIVIFLYTMIILSNMTIILLSYMNPQlytpMYFFLSNLSFLDLCFTTTVVPQMLFNLwgpdKSITYigCIIQLGMV 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 14423800  105 LALGSTECLLLAVMCFDRFVAICRPlhYSIIMhQRLCFQLAAASWISGFSNSVLQSTwtlkMPLCGHkEVDHFfCEVPAL 184
gi 311033421 105 LWLGATECILLVVMAFDRYVAVCRPlrYTAIMnPQLCWLLAVIACLGGLGNSVIQSTftlqLPLCGHrRVEGFlCEVPAM 184
gi 33238954  107 HWLGCTECVLLGIMALDRYVAVCKPlrYSVIMdHRLCLQLSGAAWLTGLANSLLQSTltiqLPLCGNrMLDHFfCELPGL 186
gi 351711645 385 NWTACAECILLAMMAIDRYVAICQPlqYTLIMhPRVCVQMAAASWSSGLANSLLQTIstlqLPLCGPhTLDHFfCEVPVL 464
gi 47576593  105 HFLGATECILLAVMSLDRYIAICKPlrYPAIMhQQFCILLMFMTWLSGLANSLLQSTltvkLPFCGNnKVDNFlCEVPVM 184
gi 74762190  109 HWLGCTECIVLAAMALDRYVAICKPlhYAVLMhRALCQQLVALAWLSGFGNSFVQVVltvqLPFCGRqVLNNFfCEVPAV 188
gi 47576611  105 HTMGGTECVLLALMSFDRYIAVCKPlhYTLIMkQRNCVLLVSIVWLIGISYAVTEATvtlqLPLCGHnKLDHLvCEIPVL 184
gi 47575909  109 HWTSCTECALLAVMALDRYVAICCPlrYVLIMhLWACVWLAAVCWASGLANSLVQATltlyLTLCAKnTLDHFfCEVPAL 188
gi 512957874 144 NWTASAECILLAMMSIDHYVAICWPlqYTVIIcPWACVHMAAPSCSSRLLNSLLQTTltlqLPLCRQhTLDHF-CELPVL 222
gi 440905600 108 LCVGATQGVMLVVMAFDRYVAICQPlrYTIIMhPQFCWKLVLMSWLSGLIESVTQTPitfqLPFCVHhCLDDFvCQVPSL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 14423800  185 LKLSCvdttaNEAELFFISVLFLLIPVTLILISYAFIVQAVlriqsaEGQRKAFGTCGSHLIVVSLFYGTAISMYLQPps 264
gi 311033421 185 IKLACgdtslNQAVLNGVCTFFTAVPLSIIVISYCLIAQAVlkirsaEGRRKAFNTCLSHLLVVFLFYGSASYGYLLPak 264
gi 33238954  187 IKMSCgdttvNEVTLAVVATFFIMGPLSMILVSYSYIAQTVfrmpsaAGRLKAFNTCSSHLLVVSLFYGPGIYIYMQPse 266
gi 351711645 465 IKLACgdttaNELALSIGAIPFGMLAPLLVVVSYIFIARAIlklpsaEGRHKALSTCSSHLLVVTMYYGPAIYVYFQPp- 543
gi 47576593  185 IKMSCantafNIAMLSIVGTFYSLVPLSLILVSYGFIVATVlrirssEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPss 264
gi 74762190  189 IKLSCadtavNDTILAVLVAFFVLVPLALILLSYGFIARAVlriqssKGRHKAFGTCSSHLMIVSLFYLPAIYMYLQPps 268
gi 47576611  185 IKTACgeketNELALSVVCIFLLAVPLCLILASYASIGHAVfkikssEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPps 264
gi 47575909  189 IKLACsdttmNDLSLALGAIPFGIVSPLTVLISYIFIARAVlklpsaEGRRKALSTCSSHLLVVTMFFGPGMYTYLQPp- 267
gi 512957874 223 IKPAFgettaNELALVIGPIPFARMAPMLVVTSDTFIARALlklpsaESRHKALSTCSSRLLVVTMYFASAMYVQLQPp- 301
gi 440905600 188 IRLTCgdtstTEWQMTISAVFFTILPMGLILTSYGYIAQTLgkiqseEGRQKAIATCSSHLTVVFMFYGTVAMVYTDPkn 267
                        250       260       270
                 ....*....|....*....|....*....|
Feature 1           ## ###  #  ##              
gi 14423800  265 psSKDRGKMVSLFCGIIAPMLNPLIYTLRN 294
gi 311033421 265 nsKQDQGKFISLFYSLVTPMVNPLIYTLRN 294
gi 33238954  267 dgSQDLIKVLTLFYCVITPMANPFIYTLRN 296
gi 351711645 544 -aKSSQTKFMSFFYCVITPVLNPLIYTLRN 572
gi 47576593  265 ssSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
gi 74762190  269 sySQEQGKFISLFYSIITPTLNPFTYTLRN 298
gi 47576611  265 siTKDQPKFMALFYGVVTPTLNPFIYTLRN 294
gi 47575909  268 -gNSTQSKLLSFFYCVCTPLLNPLIYTLRN 296
gi 512957874 302 --KNHTQAKFMSFYXVITPVLNTLIYTLRN 329
gi 440905600 268 hfASKHGKFVSFFFTVITPLLNPLIYTLRN 297

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