Conserved Protein Domain Family
7tmA_OR52I-like

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cd15950: 7tmA_OR52I-like 
olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320616
View PSSM: cd15950
Aligned: 10 rows
Threshold Bit Score: 426.445
Threshold Setting Gi: 218512129
Created: 17-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 218512129  55 LWLAISLSAMYIIALLGNTIIVTAIWMDSTRHePMYCFLCVLAAVDIVMASSVVPKMVSIFCsgdSSISfsaCFTQMFFV 134
gi 449277325  41 FWIAFPFCTMYFMAVLGNITVLLAIWMDPSLHlPMFYFLSMLAAIDLVLITSTMPKLLSIFWfhsHEIDfegCVAQMFFI 120
gi 21928977   11 FWIAFPFCSMYALAVLGNMVVLLVVHSEPVLHqPMYLFLCMLSTIDLVLCTSTVPKLLALFWakdAEINfgaCAAQMFFI 90
gi 483509418  27 IWFSIPFCFMYVMTLLGNITILLAVRLDKSLHePMYYFISMLAVIDLIFSTAVVPKLLGVFWlgsREIVfeaCFIQMFFI 106
gi 530655857  29 VWMGIPFCSMYIIALLGNSIILIIVRLDQTLHePMYYFLCMLAAIDLVMTTSIVPKMLGIFWlnsMEIAfdaCFTQMFFV 108
gi 557317914  27 VWISIPFCFMYVVTLVGNCTLLWVIKREPSLHlPMYLFLSMLALVDLVMSTSITPNMLGIFWlhsTAISvdaCLAQMYFV 106
gi 449277324  27 LWISIPFCIMYLVTLVGNCTILYVIKADPSLHlPMFLFLSMLAVIDLVMSTSITPKMLGIFWfhsTTISlgaCLTQMYFV 106
gi 449277323  29 TCLGILFCSSYIIALVGNGLVLLVIGLDNSLRePVHCFLGMLAVIDVVMVTSIVPKMLSVFWlnsKEIGyvaCFVQMFLV 108
gi 558178086  25 FWIAFPFCAMYLVALLGNSTLLFVIKTEPSLHlPMYYFLCMLAGIDLVLTSSTVPKILSIFWfrsHEIGfecCMVQMFFI 104
gi 543366676  26 TCLGILFCSAYVLAMAGNGVVLLVLGLDKALQaPSHCFLGMLAVVDVLMVTSVIPRMLSVLWlgsAEIGsvaCFVQMFLV 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 218512129 135 HLATaVETGLLLTMAFDRYVAICKPLhYKRILtPQVMLGMSMAITIRAIIAITPLSWmvshLPFCGSnVVVHSYCEHIAL 214
gi 449277325 121 HSFSiAESGVLLTMAFDRYLAICKPLhYSAILtGPTTAKLGLAAVGRGTAIIIPLSSmvasLSYCGShVIDHSYCEHMSM 200
gi 21928977   91 HGFSaVESGILLAMAFDRYLAICWPLhYGSLLsPESVGKLGAAAVLRGLGLMTPLTCllarLSYCSR-VVAHSYCEHMAV 169
gi 483509418 107 HTSTaVESGVLLAMSFDRYIAICNPLrYSTILtSSRTTQIGLLSLARGAAVMTPLMClltsLSYCKSrVIPHSYCEHMAV 186
gi 530655857 109 HSITaAESGVLLAMAFDRYVAICYPLrYQAILtRQKVTQIGLAILLRAGLVMTPVTWmmkrLPYCGSnVIAHSYCEHMAV 188
gi 557317914 107 HAFSvMESGLLVAMAFDRYVAICHPLrYKVILtSPVIAAIGLVMLGRGLALMTPLTCilrgYPFCQDsAISHSYCEHMAV 186
gi 449277324 107 HAFSaVESGVLVAMAFDRYVAICHPLqYLSILtSPVVVVIGLATLLRAVVFMTPLTFqircLPLCGPaIVGHSYCEHMAV 186
gi 449277323 109 HSTTaEESGVLLAMAIDRYIAICHPLrYQAILtRQTIAQIGLAIVVRALLFMVPLAGmmtnLPYCRSrVVPHSYCEHMAV 188
gi 558178086 105 HGFSaVESGVLLAMAYDRYIAVCRPLhYSAILtDAVIAKMGSAAFLRGLGLMTPLTClvsrLPYCGPrLISHSYCEHMAV 184
gi 543366676 106 HSTTaEESGVLLAVAFDRYLAVCHPLrYRCILtGRAIAQVGLAIVLRALLFTVPLMVlvtsLPYCGSrPVPHSYCEHLAL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 218512129 215 ARLACADpvpSSLYSLIGSSLMVGSDVAFIAASYILILKAVfglsskTAQLKALSTCGSHVGVMALYYLPGMASIYAAWL 294
gi 449277325 201 VKLACGDtrpNCIYGITVATIVVGSDSILIAVSYRLILREVlglssrEARLKSFCTCGSHIAVILLFYIPGLFSFYTDRW 280
gi 21928977  170 VKLACGGtqpNNIYGITAATLVVGTDSICIAVSYALILRAVlglsskEARAKTFGTCGSHLGVILLFYTPGLFSFYTQRF 249
gi 483509418 187 VKLACADpsvSDLYSIIVATLLVGTDSVFITLSYGMILRSVlrlpsqEARLKALSTCGSHICIILLFYIGGLLSMYLQMF 266
gi 530655857 189 VKLACADpraISQYCVVGPTLLVGTDTAFISVSYGMILRAVlrlaekEARLKAIGTCGSHLCVMLLYYLPGMASIYTQSF 268
gi 557317914 187 IKLACGDtalGTTYSILVSTYVGGVDSLLIALSYGLILKAVlglssaEARHKTFSTCASHVCVIALFYIPGLLSMYIERY 266
gi 449277324 187 LRLSCEDaafSSTYSLSISTCVVSFDSLLIAISYVLILRAVlglsspQARKKAFGTCVSHFCIMALYYIPGLLSMYMERY 266
gi 449277323 189 AKLACVDprpNRLYSVAGSSLIVGMDVAFIAVSYGMILKTVlg---kRSCRKALRTCGCHICTMLLYYVPGIVSIYAQQF 265
gi 558178086 185 VKLACGGttpNDVYGITAATFVVGSDSIFIAVSYILILQAVlnlssrEARWKSFSTCGSHVCVILVFYTPGLFSFYTQRW 264
gi 543366676 186 AGLACAGpgpSGPYSVAWSSLVVGTGLAFIAVSYGVILRAVlg---kEPGWKALSTCGCHLCVVLLFYVPGIVSIYCQRF 262
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1              ## ###  #  ##                 
gi 218512129 295 GqdvvPLHTQVLLADLYVIIPATLNPIIYGMRTKQL 330
gi 449277325 281 Gqs-iPAHLRILVADLYLLVPPMLNPLIYGMRTKQI 315
gi 21928977  250 Gqh-vPRHIHILLADLYLVVPPMLNPIIYGMKTKQI 284
gi 483509418 267 Sfg-lAPHVQVLVADFYLTVPPMLNPFIYGLKVKQI 301
gi 530655857 269 Gqg-vARWTQVLLADLYLTLPPMLNPVIYSMRTKQV 303
gi 557317914 267 Gqd-iPPHVQVLMADLYLLIPPMFNPIIYGMKMKQI 301
gi 449277324 267 Hqe-lPPHIQVLLADLYLLIPPAFNPLIYGIRTKQI 301
gi 449277323 266 Ssg-iPVHAQVLLADVYLILPAMLNPVVYSIRTKQI 300
gi 558178086 265 Gqn-iPMHIRILLADLYLLVPPMLNPIIYGMKTKQI 299
gi 543366676 263 Pga-vAAGTRVLLADLYLALPATLNPLVYSARSRQL 297

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