Conserved Protein Domain Family
7tmA_OR52R_52L-like

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cd15951: 7tmA_OR52R_52L-like 
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320617
View PSSM: cd15951
Aligned: 15 rows
Threshold Bit Score: 394.406
Threshold Setting Gi: 296439491
Created: 17-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 223590113  28 LWIAFPFCATYAVAVVGNITLLHVIRIDHTLHePMYLFLAMLAITDLVLSSSTQPKMLAIFWfhaHEIQyhaCLIQVFFI 107
gi 465953706  27 HWVAIPLCFMYIVALLGNGIVLFVIRTDPSLHePMYVFLAMLTITDLVLSTSTLPKMLSIFWlgsREIGfhaCLTQLFFI 106
gi 47576681   38 MWISIPFCMVYILALVGNSSLLFIIKTDSSLHePMYLFLCMLAVADLVVCTTAVPKLLSVFWfhdGEIRfeaCLTQIFLI 117
gi 296439491  43 HWIALPLGILYLLALVGNVTILFIIWMDPSLHqSMYLFLSMLAAIDLVLASSTAPKALAVLLvhaHEIGyivCLIQMFFI 122
gi 57770655   28 FWIAFPFCIMYAIAVLGNIILLIIIKTESSLHePMYLFLAMLAFTDLVLSTSMVPKMLTVFWrgsREIGfvsCLVQLFFV 107
gi 465955008  34 VWISIPFCSVYLLSLLGNGLLLAVTKTEPSLHePMYLFLSTLALADLIISTTTLPKALCIFWfsdRAIHtnsCLAQIFLI 113
gi 557328859  28 IWLAIPFCCMYLVAVMGNCIILLVIKMERSLHePMYLFLCMLSVTDLVLSSSTLPKMLSIFWfdaREIDfgaCLTQMFFI 107
gi 47575989   34 TWLSVPFCLVYLGAHLGNFPLLFIVRIDSNPHePMYFFLCMLSDTDLILSTTAMPKILSNFWfhnREIHfeaCLVQVFLI 113
gi 465953527 105 VWISIPFCTMYIIAVLGNFTILFIVKRETSLHgPMYYFLCMLAITDLVLCTSILPKTLSIFWfnsREIDfsaCLTQLYFI 184
gi 521023968   3 IWISIPFCSMYVVALMGNILILFIIKTEIALHePMFYFLSMLAITDLILSTSTLPKMLVVFWfnyHEINfhaCLTQMFFI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 223590113 108 HAFSsVESGVLMAMALDCYVAICFPLrHSSILtPSVVIKLGTIVMLRGLLWVSPFCFmvsrMPFCQHqAIPQSYCEHMAV 187
gi 465953706 107 HASSlVESGILVAMALDRYVAICNPLrHAAILkISMVAKIALLVLVRGLVVIAPLPLllrrLPFCQAyIIPHSYCEHMAV 186
gi 47576681  118 HSCStMESGFFLAMAFDRYIAICNPLrHSAILtRTLTGGIGLAVVLRGIALLSPHPFllrwLPYCKTnIISHTYCEFMAL 197
gi 296439491 123 HAFSsMESGVLVAMALDCYVAICHPLhHSTILhPGVIGCIGMVVLVRGLLLLIPFPIllgkLIFCQAtIIGHAYCEHMAV 202
gi 57770655  108 HNFTtVESGVLMAMALDRYFAICHPLrHSSILsMPVVAALGSLVLLRGFLMVGPACFllhkKAFCQHrVISHSYCEHMAV 187
gi 465955008 114 HSLAtMESGFMLAMAFDRYIAICNPLqHSAILtHQAIAKIGVGVVMRGAMLLGPHPFllkwLPYCRThVISHTYCEFMAL 193
gi 557328859 108 HSFTaMESGFFVAMAYDRYVAICNPLrHATILtHSRIAKIGCTVVVRGMVFFSPHPFlvsrLPFCRTnIISHSYCEFMAL 187
gi 47575989  114 RSLCsMASGFILAMALDRYVAICNALrHSAIPtHGVIRNLGIMSVVRGGLLFSPQPLmlrwLPYCRTnTIPHTYCEFMAL 193
gi 465953527 185 HCFSvIESGIFVAMGFDRYVAICHPLrHSTTLtNPVVAKIGLAMVLRGGMLVMPHPFlarwRPYCRTnIISHTLCEHMAV 264
gi 521023968  83 HAFSgVESGLLVAMVLDRYVAICNPLrHSSILtNSVVVQVGIVALLRGLVLMTPHPFlvkrWPYCRTnIVPHTYCEHMAV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  ### ### ##                                            #  ## ##  #  
gi 223590113 188 LKLVCADtsiSRGNGLFVAFSVAGFDMIVIGMSYVMILRAVlqlpsgEARLKAFSTRSSHICVILALYIPALFSFLTYRF 267
gi 465953706 187 VKLACTDttvNAAYGLVMALLVGGLDGMSITLSYVMILQAVfglpstQARLKALSTCMSHICVILMFYIPGLFSFLVHRF 266
gi 47576681  198 IKIACAEtsiRRAYSLIVAFLTGGVDFILIICSYVLILNTVfhlpskDARLKTLGTCGSHVCVILVSYTPAFFSFLTHRF 277
gi 296439491 203 VKLACSEttvNRAYGLTMALLVIGLDVLAIGVSYAHILQAVlkvpgsEARLKAFSTCGSHICVILVFYVPGIFSFLTHRF 282
gi 57770655  188 VKLVCEDtrvNAAYGLSVAVAVIGVDLTLIIVSYTMILRVVlklsasDTQLKAFNTCVSHICVILAFYVSGLFTFLTHRF 267
gi 465955008 194 VKLACADttvMRAYGLLVAFLTAGLDFNLIVLSYILILQAVfnlpskDARHKSLSTCGSHICVMLVFYTPAFFSFLSHRF 273
gi 557328859 188 VKLACVDvavTKEYSLTVASLIGSFDIFFTSLSYALILQTVtrlpskEASLKAFSTCGSHICVILVFYSTAVFTFLTHRF 267
gi 47575989  194 IKLACAEtriFRLYSLTAAFLTGSLDFISIICSYIVILYTVfrlpskAARLKTLGTCGSHVCVILVAYTPAFFSFLTHRC 273
gi 465953527 265 VKLACSDtriSSYYGLFVVFCVLGLDVFFITMSYTQILRAIfilptkDARLKTFGTCASHLCAILPFYVSTIFSSLTYRF 344
gi 521023968 163 VKLACADisiNSLYSLAVIILIVGTDVACISLSYIQILRTVfklpskDARLKTLSTCGSHVCVILTFYIPALFSFLTHRF 242
                        250       260       270
                 ....*....|....*....|....*....|....*
Feature 1             ## ###  #  ##                 
gi 223590113 268 GhdvPRVVHILFANLYLLIPPMLNPIIYGVRTKQI 302
gi 465953706 267 GqsvPNPIHILLANLYLLVSPMLNPIVYGVKNKQI 301
gi 47576681  278 GhkvAPQVHIFVANIYLLVPPMVNPIIYGVRTKKI 312
gi 296439491 283 GhhvPHHVHVLLATWYLLMPPALNPLVYGVKTQQI 317
gi 57770655  268 GhsiPQHIHILVADIYLLLPPTLNPIIYGVRTKQL 302
gi 465955008 274 Gh-vAPHVHILIANMYILFPPMMNPIIYGVRTPRI 307
gi 557328859 268 GhnvAPHIHILIANVYLLVPPMLNPVIYGVRTKRI 302
gi 47575989  274 GhnvAPHIHIFVANIYLLVPPLANPMIYGIRTKTI 308
gi 465953527 345 GqnvALHFHVLIANVYLLVPPMLNPIIYGVRTKQI 379
gi 521023968 243 SkhvPRHTHILLANMYLLVPPMLNPVIYGVRTKQI 277

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