Conserved Protein Domain Family
7tmA_OR52E-like

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cd15952: 7tmA_OR52E-like 
olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320618
View PSSM: cd15952
Aligned: 11 rows
Threshold Bit Score: 438.738
Threshold Setting Gi: 564230347
Created: 17-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 296439248  27 IWIGFPFCAVYMIALIGNFTILLVIKTDSSLHqPMFYFLAMLATTDVGLSTATIPKMLGIFWinlRGIIfeaCLTQMFFI 106
gi 345316451  27 TWIAFLICLMYVTALAGNSIMLLVIGREPGLHsPMFFFICFLSTTDIFLSSATIPKMLAIMWlqaREISfdsCIAQMVFI 106
gi 47576781   35 FWLGFPFSVVYLIALVGNIIILFVIWTDRTLHqPMFYFLAMLSVVDLSLSTATIPKMLSIFWfrlQELCfgcCVAQVFFI 114
gi 564230347  34 FWVAFPVGLVYMVALLGNCMVLAVVRAEQSLHtPMYYFLCMLAAVDLVLATSTVPKMLAIFWagaREISfhaCLAQMFFI 113
gi 47576767   27 FWLGFPFGTVYLTAVLGNVILLFVVHLEHSLHqPMFYLLAMLALTDLGLSTATVPRALGIFWfgfHKIAfrdCIAQMFFI 106
gi 38372697   27 IWISFPFCIVYLIAIVGNMTILFVIKTEHSLHqPMFYFLAMLSMIDLGLSTSTIPKMLGIFWfnlQEISfggCLLQMFFI 106
gi 20532197   27 IWIGFPFFSVYLIALLGNAAIFFVIQTEQSLHePMYYCLAMLDSIDLSLSTATIPKMLGIFWfniKEISfggYLSQMFFI 106
gi 38372705   24 LWVGFPFFAVFLTAVLGNITILFVIQTDSSLHhPMFYFLAILSSIDPGLSTSTIPKMLGTFWftlREISfegCLTQMFFI 103
gi 558113906  27 VWISIPFCAIYIITLLGNCTILFIVKTEPRLHqPMYYLLCVLSAVDLGLSTATVPRMLGIFWfnlREIRlegCLTQMFFI 106
gi 602643026  27 GWLSIPFCAGFLVALLGNVTILFVVKTEASLHqPMFYFLCLLSFIDLGLSMTTLPKMLAIFWfglGETTfdsCLAQMFFI 106
gi 296439249  27 MWISGPFCSVYLVALLGNATILLVIKVEQTLRePMFYFLAILSTIDLALSTTSVPRMLGIFWfdaHEINygaCVAQMFLI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 296439248 107 HNFTlMESAVLVAMAYDSYVAICNPLqYSAILtNKVVSVIGLGVFVRALIFVIPSILLilRLPFCGNh-VIPHTYCEHMG 185
gi 345316451 107 HLFTgVESGILVAMAFDRYMAICRPLrYRVILtDRLVVKLGLTALLRPLLIVLPFILLikRLHFCKAt-ILPHSYCEHMG 185
gi 47576781  115 HFFTvMESIVLLAMGFDRYVAICNPLrYTTILtNRVIGVIAALVVIRSLCMIVPIIFLllRLPYCGHr-IIPHTYCEHMG 193
gi 564230347 114 HTFTaTESGVVLAMAFDRYVAICAPLhYTAVLtSQRVVVIGMAALARGVLIILPVPFLtlRLRYCGPn-IISHAYCEHMG 192
gi 47576767  107 HLFTgIETFMLVAMAFDRYIAICNPLrYNTILtNRVICIIAGIGLFKNFILIFPLIFLilRLSFCGHn-VIPHTYCEHMG 185
gi 38372697  107 HMFTgMETVLLVVMAYDRFVAICNPLqYTMILtNKTISILASVVVGRNLVLVTPFVFLilRLPFCGHn-IVPHTYCEHRG 185
gi 20532197  107 HFFTvMESIVLVAMAFDRYIAICKPLwYTMILtSKIISLIAGIAVLRSLYMVIPLVFLllRLPFCGHr-IIPHTYCEHMG 185
gi 38372705  104 HLCTgMESAVLVAMAYDCYVAICDPLcYTLVLtNKVVSVMALAIFLRPLVFVIPFVLFilRLPFCGHq-IIPHTYGEHMG 182
gi 558113906 107 HTFTgMESAILLAMAFDRYVAICDPLrYTVILaQKRITLIGLGIVLRPGVLVLPMVFLvgQLPFCSIr-VLAHSYCEHMG 185
gi 602643026 107 HTFTgMESAVLLAMAFDRYVAICDPLrYSTILtQDQIIWISLGIILKPAILMLPILVMtkRLPFCRAhiNMAHTYCEHMG 186
gi 296439249 107 HAFTgMEAEVLLAMAFDRYVAVCAPLhYATILtSQVLVGISMCIVIRPVLLTLPMVYLiyRLPFCQAh-IIAHSYCEHMG 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                            #  ## ##  # 
gi 296439248 186 LAHLSCASIk-INIIYGLCAICNLVFDITVIALSYVHILCAVfrlpthEARLKSLSTCGSHVCVILAFYTPALFSFMTHR 264
gi 345316451 186 IAKLACSDIrvNVVYGLTGALLVFSVDLVLIGLSYSLILRAVlrlptkEARVKAFSTCGSHVSVMMVFYTPALFSFLTHR 265
gi 47576781  194 VARLACASIr-ANVYFGLGNISILFLDVLLIIVSYARILYAVfhlpsqDARVKALNTCSSHICVILAFFGPALFSFLTHR 272
gi 564230347 193 IAKLACTDIrvNRLYGLVIALLVMGLDLLLIGLSYALILRAVlslpshKARFKAFSTCGSHLCVILAFFTPALFSFITHR 272
gi 47576767  186 IARLACVSIk-VNVLFGLLLISMILLDVILIALSYVKILHAVfklpswEARLKALNTCGSHVCVILAFFTPAFFSFLTHR 264
gi 38372697  186 LAGLACAPIk-INIIYGLMVISYIIVDVILIASSYVLILRAVfrlpsqDVRLKAFNTCGSHVCVMLCFYTPAFFSFMTHR 264
gi 20532197  186 IARLACASIk-VNIMFGLGSISLLLLDVLLIILSHIRILYAVfclpswEARLKALNTCGSHIGVILAFSTPAFFSFFTHC 264
gi 38372705  183 IARLSCASIr-VNIIYGLCAISILVFDIIAIVISYVQILCAVfllsshDARLKAFSTCGSHVCVMLTFYMPAFFSFMTHR 261
gi 558113906 186 LAKLACADIr-ANGEYDLFLVSLLVLDVILIFLSYVRILQAVfllpskDARLKALSTCSSHVGVMFVFYSPVLFSYLTHR 264
gi 602643026 187 IAKLACADIr-INAIYGLFVASFLVLDLILIAISYMKILQAVfrlsskEAQLKSLGTCGSHVAVIFVFYTPAFFSFLTHR 265
gi 296439249 186 IAKLSCGNIr-INGIYGLFVVSFFVLNLVLIGISYVYILRAVfrlpshDAQLKALSTCGAHVGVICVFYIPSVFSFLTHR 264
                        250       260       270
                 ....*....|....*....|....*....|....*.
Feature 1              ## ###  #  ##                 
gi 296439248 265 FGrnvPRYIHILLANLYVVVPPMLNPVIYGVRTKQI 300
gi 345316451 266 FGhhvPRFVHILLANFYVVLPPMLNPIIYGVKTKQI 301
gi 47576781  273 FGhniPQYIHILLANLYVVIPPALNPVIYGIRTKQI 308
gi 564230347 273 FGhgvPLYVHILLAVLYVLLPPMLNPLIYGVKTRQI 308
gi 47576767  265 FGhniPQYIHILLANLYVMIPPALNPLIYGVRTKQI 300
gi 38372697  265 FGqniPHYIHILLANLYVVVPPALNPVIYGVRTKQI 300
gi 20532197  265 FGhdiPQYIHIFLANLYVVVPPTLNPVIYGVRTKHI 300
gi 38372705  262 FGrniPHFIHILLANFYVVIPPALNSVIYGVRTKQI 297
gi 558113906 265 FGqqiPRSAHILVASFHILLPPMLNPIIYGVRAKEI 300
gi 602643026 266 FGhniPHFAHILVANLYVILPPMLNPVIYGVRTGEI 301
gi 296439249 265 FGhqiPGYIHILVANLYLIIPPSLNPIIYGVRTKQI 300

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