Conserved Protein Domain Family
7tmA_OR52N-like

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cd15954: 7tmA_OR52N-like 
olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320620
View PSSM: cd15954
Aligned: 4 rows
Threshold Bit Score: 464.296
Threshold Setting Gi: 557317918
Created: 17-Dec-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                #  ##           ###### #
gi 38372698   27 IWISLPFCFMYIIAVVGNCGLICLISHEEALHrPMYYFLALLSFTDVTLCTTMVPNMLCIFWfnlKEIDfnaCLAQMFFV 106
gi 557317926  27 IWISIPFFFAYLIGLVGNCGLLYLIWIEETLHrPMYYFLSMLSITDIAATTTVIPKAMCIFWlklKETNfnaCLVQMFFI 106
gi 602643190  27 LWISFPFFSMYLIGMVGNCGLLYIIWAEEVLHrPMYYFLCMLSVTDIIMGTSTMPKAFCIFWlnlEEISfssCLVQMYVV 106
gi 557317918  27 LWISIPFCSMYIIAMVGNCGLLYLIRIEDALHkPMYYFLSMLSLTDIGLVTSMVPKAMCIFWfkmKKISfnaCLTQMFFV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                                            # #####                         
gi 38372698  107 HMLTgMESGVLMLMALDRYVAICYPLrYATILtNPVIAKAGLATFLRNVMLIIPFTLlt-krLPYCRGnFIPHTYCDHMS 185
gi 557317926 107 HTFAgMESGVLMLMAVDRYVAISYPLrYTTILtHPIITAAGLLNFLRGMIVAAPFPLwa-krLPYCRGnVIPHTYCDHMS 185
gi 602643190 107 HTFTgMESGVLMLMALDRFVAICYPLrYATILtNPIILKVGLFTFLRGAVLILPFPFlv-rnMKYWGSrAIAHTYCDHMA 185
gi 557317918 107 HTFTgMESGVLMLMSLDRYLAICYPLrYASILtNPVITTAGVVTFLRGVMVIIPVVVftkrlPYCHHTnIIPHTYCDHMS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  ### ### ##                                            #  ## ##  # 
gi 38372698  186 VAKVSCGNfkvNAIYGLMVALLIGVFDICCISVSYTMILQAVmslssaDARHKAFSTCTSHMCSIVITYVAAFFTFFTHR 265
gi 557317926 186 VVKLACASirvDAIYGLAAAGLVGGLDILCISFSYVMILRAVlglsskEARSKAFSTCTAHICAILSTYTPAFFTFFAHR 265
gi 602643190 186 VVKLACSNirvDAIYGLTVALLIGGFDILCITTSYAMILKAVvglsspEQRSKAFGTCSAHICAIVISYTPAFFTFFAHR 265
gi 557317918 187 VVKLACASirvDAIYGLVAALVIGGFDIFCISVSYAMILRAVvs--skEARSKAFSTCTAHICAIITSYTPALFSILAHR 264
                        250       260       270
                 ....*....|....*....|....*....|....*..
Feature 1               ## ###  #  ##                 
gi 38372698  266 FVghniPNHIHIIVANLYLLLPPTMNPIVYGVKTKQI 302
gi 557317926 266 FGghhiAPYAHIIMANLYLLLPPMLNPIIYGVKIKQI 302
gi 602643190 266 FGghhiTPHVHIIMANLYLLLPPMMNPIVYGVKTKEI 302
gi 557317918 265 FGshhiTAHTHILIANLYLLLPPMLNTIVYGVKTKQI 301

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